Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation

Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation

Arachidonic acid metabolites resulting from the cyclooxygenase (COX), lipoxygenase, and cytochrome P450 oxidase enzymatic pathways play pro- and anti-inflammatory roles in allergic airway inflammation (AAI) and asthma. Expression of COX-2 and soluble epoxide hydrolase (sEH) are elevated in allergic...

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Bibliographic Details
Main Authors: Mythili Dileepan, Stephanie Rastle-Simpson, Yana Greenberg, Dayanjan S. Wijesinghe, Naren Gajenthra Kumar, Jun Yang, Sung Hee Hwang, Bruce D. Hammock, P. Sriramarao, Savita P. Rao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
eosinophilia
allergic airway inflammation
pharmacological inhibition
COX-2
soluble epoxide hydrolase
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01118/full

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