The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice
Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia–reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Trea...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319310278 |
| _version_ | 1819265149921394688 |
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| author | Hiroko Sonoda Worapat Prachasilchai Hiroaki Kondo Naoko Yokota-Ikeda Sayaka Oshikawa Katsuaki Ito Masahiro Ikeda |
| author_facet | Hiroko Sonoda Worapat Prachasilchai Hiroaki Kondo Naoko Yokota-Ikeda Sayaka Oshikawa Katsuaki Ito Masahiro Ikeda |
| author_sort | Hiroko Sonoda |
| collection | DOAJ |
| description | Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia–reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury. Keywords:: radicicol, renal ischemia–reperfusion injury, heat shock protein 70 kDa (HSP70) |
| first_indexed | 2024-12-23T20:40:48Z |
| format | Article |
| id | doaj.art-0101c7b287dc43969a5877427cd1a422 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-23T20:40:48Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-0101c7b287dc43969a5877427cd1a4222022-12-21T17:31:56ZengElsevierJournal of Pharmacological Sciences1347-86132010-01-011122242246The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in MiceHiroko Sonoda0Worapat Prachasilchai1Hiroaki Kondo2Naoko Yokota-Ikeda3Sayaka Oshikawa4Katsuaki Ito5Masahiro Ikeda6Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Kita-Takamatsu 5-30, Miyazaki 880-8510, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan; Corresponding author. a0d302u@cc.miyazaki-u.ac.jpOverexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia–reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury. Keywords:: radicicol, renal ischemia–reperfusion injury, heat shock protein 70 kDa (HSP70)http://www.sciencedirect.com/science/article/pii/S1347861319310278 |
| spellingShingle | Hiroko Sonoda Worapat Prachasilchai Hiroaki Kondo Naoko Yokota-Ikeda Sayaka Oshikawa Katsuaki Ito Masahiro Ikeda The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice Journal of Pharmacological Sciences |
| title | The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice |
| title_full | The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice |
| title_fullStr | The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice |
| title_full_unstemmed | The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice |
| title_short | The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice |
| title_sort | protective effect of radicicol against renal ischemia reperfusion injury in mice |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319310278 |
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