Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s Disease
Nonadherence is a growing issue in the treatment of Parkinson’s disease (PD). Many factors are known to influence nonadherence, but little is known about the influence of quality of life (QoL). Detailed clinical data were obtained from 164 patients with PD using the Parkinson’s Disease Questionnaire...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/2/273 |
| _version_ | 1797395615056920576 |
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| author | Hannah M. Zipprich Sarah Mendorf Thomas Lehmann Tino Prell |
| author_facet | Hannah M. Zipprich Sarah Mendorf Thomas Lehmann Tino Prell |
| author_sort | Hannah M. Zipprich |
| collection | DOAJ |
| description | Nonadherence is a growing issue in the treatment of Parkinson’s disease (PD). Many factors are known to influence nonadherence, but little is known about the influence of quality of life (QoL). Detailed clinical data were obtained from 164 patients with PD using the Parkinson’s Disease Questionnaire-39 (PDQ-39) and the German Stendal Adherence with Medication Score (SAMS). Descriptive statistics were used to identify reasons for nonadherence, and multivariable linear models were used to study associations between QoL and clinical parameters as well as nonadherence. Multivariate analysis of variance (MANOVA) and multivariate analysis of covariance (MANCOVA) were used to study the effect of the SAMS on PDQ domains and other medical covariates. The results showed that 10.4% (<i>n</i> = 17) of patients were fully adherent, 66.4% (<i>n</i> = 109) were moderately nonadherent, and 23.2% (<i>n</i> = 38) were nonadherent. Nonadherence was associated with male gender, lower Montreal Cognitive Assessment (MoCA) score, higher non-motor symptoms questionnaire (NMS-Quest) score, greater number of medications per day (an indicator of comorbidity), and higher Beck Depression Inventory (BDI) score. QoL was correlated with male gender, lower MoCA score, higher NMS-Quest score, more comorbidities, and higher BDI score, but was not correlated with nonadherence. |
| first_indexed | 2024-03-09T00:38:02Z |
| format | Article |
| id | doaj.art-0101c7fbf5ac4a50814b823efbc43815 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T00:38:02Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-0101c7fbf5ac4a50814b823efbc438152023-12-11T17:59:17ZengMDPI AGBrain Sciences2076-34252021-02-0111227310.3390/brainsci11020273Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s DiseaseHannah M. Zipprich0Sarah Mendorf1Thomas Lehmann2Tino Prell3Department of Neurology, Jena University Hospital, 07747 Jena, GermanyDepartment of Neurology, Jena University Hospital, 07747 Jena, GermanyCenter for Clinical Studies, Jena University Hospital, 07747 Jena, GermanyDepartment of Neurology and Center for Healthy Ageing, Jena University Hospital, 07747 Jena, GermanyNonadherence is a growing issue in the treatment of Parkinson’s disease (PD). Many factors are known to influence nonadherence, but little is known about the influence of quality of life (QoL). Detailed clinical data were obtained from 164 patients with PD using the Parkinson’s Disease Questionnaire-39 (PDQ-39) and the German Stendal Adherence with Medication Score (SAMS). Descriptive statistics were used to identify reasons for nonadherence, and multivariable linear models were used to study associations between QoL and clinical parameters as well as nonadherence. Multivariate analysis of variance (MANOVA) and multivariate analysis of covariance (MANCOVA) were used to study the effect of the SAMS on PDQ domains and other medical covariates. The results showed that 10.4% (<i>n</i> = 17) of patients were fully adherent, 66.4% (<i>n</i> = 109) were moderately nonadherent, and 23.2% (<i>n</i> = 38) were nonadherent. Nonadherence was associated with male gender, lower Montreal Cognitive Assessment (MoCA) score, higher non-motor symptoms questionnaire (NMS-Quest) score, greater number of medications per day (an indicator of comorbidity), and higher Beck Depression Inventory (BDI) score. QoL was correlated with male gender, lower MoCA score, higher NMS-Quest score, more comorbidities, and higher BDI score, but was not correlated with nonadherence.https://www.mdpi.com/2076-3425/11/2/273nonadherenceParkinson’s diseaseunified Parkinson’s disease rating scaleGerman Stendal Adherence with Medication Scorequality of lifemotor impairment |
| spellingShingle | Hannah M. Zipprich Sarah Mendorf Thomas Lehmann Tino Prell Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s Disease Brain Sciences nonadherence Parkinson’s disease unified Parkinson’s disease rating scale German Stendal Adherence with Medication Score quality of life motor impairment |
| title | Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s Disease |
| title_full | Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s Disease |
| title_fullStr | Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s Disease |
| title_full_unstemmed | Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s Disease |
| title_short | Self-Reported Nonadherence to Medication Is Not Associated with Health-Related Quality of Life in Parkinson’s Disease |
| title_sort | self reported nonadherence to medication is not associated with health related quality of life in parkinson s disease |
| topic | nonadherence Parkinson’s disease unified Parkinson’s disease rating scale German Stendal Adherence with Medication Score quality of life motor impairment |
| url | https://www.mdpi.com/2076-3425/11/2/273 |
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