Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats

Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats

Hypocretin/orexin (HCRT) is a neuropeptide that is associated with both stress and reward systems in humans and rodents. The different contributions of signaling at hypocretin-receptor 1 (HCRT-R1) and hypocretin-receptor 2 (HCRT-R2) to compulsive alcohol drinking are not yet fully understood. Thus,...

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Bibliographic Details
Main Authors: Gabriel M. Aldridge, Tyler A. Zarin, Adam J. Brandner, Olivier George, Nicholas W. Gilpin, Vez Repunte-Canonigo, Pietro Paolo Sanna, George F. Koob, Leandro F. Vendruscolo, Brooke E. Schmeichel
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Addiction Neuroscience
Subjects:
Hypocretin/orexin
Alcohol
Central amygdala
Retrograde-adeno-associated viral vector
Alcohol-dependence
Self-administration
Online Access:http://www.sciencedirect.com/science/article/pii/S2772392522000232

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http://www.sciencedirect.com/science/article/pii/S2772392522000232

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