Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management
Conveyance of pathogens between organisms causes communicable diseases. On the other hand, a non-communicable disease (NCD) was always thought to have no causative transmissible infective agents. Today, this clear distinction is increasingly getting blurred and NCDs are found to be associated with s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.966152/full |
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| author | Abhiram Kumar Abhiram Kumar Kalyani Sakhare Dwaipayan Bhattacharya Raktim Chattopadhyay Purvish Parikh Kumar P. Narayan Anubhab Mukherjee |
| author_facet | Abhiram Kumar Abhiram Kumar Kalyani Sakhare Dwaipayan Bhattacharya Raktim Chattopadhyay Purvish Parikh Kumar P. Narayan Anubhab Mukherjee |
| author_sort | Abhiram Kumar |
| collection | DOAJ |
| description | Conveyance of pathogens between organisms causes communicable diseases. On the other hand, a non-communicable disease (NCD) was always thought to have no causative transmissible infective agents. Today, this clear distinction is increasingly getting blurred and NCDs are found to be associated with some transmissible components. The human microbiota carries a congregation of microbes, the majority and the most widely studied being bacteria in the gut. The adult human gut harbors ginormous inhabitant microbes, and the microbiome accommodates 150-fold more genes than the host genome. Microbial communities share a mutually beneficial relationship with the host, especially with respect to host physiology including digestion, immune responses, and metabolism. This review delineates the connection between environmental factors such as infections leading to gut dysbiosis and NCDs and explores the evidence regarding possible causal link between them. We also discuss the evidence regarding the value of appropriate therapeutic immunomodulatory nutritional interventions to reduce the development of such diseases. We behold such immunomodulatory effects have the potential to influence in various NCDs and restore homeostasis. We believe that the beginning of the era of microbiota-oriented personalized treatment modalities is not far away. |
| first_indexed | 2024-04-11T09:50:19Z |
| format | Article |
| id | doaj.art-01036cb68c0c45fca70c2fcf17a93a19 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T09:50:19Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-01036cb68c0c45fca70c2fcf17a93a192022-12-22T04:30:49ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.966152966152Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their managementAbhiram Kumar0Abhiram Kumar1Kalyani Sakhare2Dwaipayan Bhattacharya3Raktim Chattopadhyay4Purvish Parikh5Kumar P. Narayan6Anubhab Mukherjee7Esperer Onco Nutrition Pvt. Ltd., Mumbai, IndiaDepartment of Biological Sciences, Birla Institute of Technology and Science – Pilani, Hyderabad, IndiaDepartment of Biological Sciences, Birla Institute of Technology and Science – Pilani, Hyderabad, IndiaDepartment of Biological Sciences, Birla Institute of Technology and Science – Pilani, Hyderabad, IndiaEsperer Onco Nutrition Pvt. Ltd., Mumbai, IndiaDepartment of Clinical Haematology, Mahatma Gandhi Medical College and Hospital, Jaipur, IndiaDepartment of Biological Sciences, Birla Institute of Technology and Science – Pilani, Hyderabad, IndiaEsperer Onco Nutrition Pvt. Ltd., Mumbai, IndiaConveyance of pathogens between organisms causes communicable diseases. On the other hand, a non-communicable disease (NCD) was always thought to have no causative transmissible infective agents. Today, this clear distinction is increasingly getting blurred and NCDs are found to be associated with some transmissible components. The human microbiota carries a congregation of microbes, the majority and the most widely studied being bacteria in the gut. The adult human gut harbors ginormous inhabitant microbes, and the microbiome accommodates 150-fold more genes than the host genome. Microbial communities share a mutually beneficial relationship with the host, especially with respect to host physiology including digestion, immune responses, and metabolism. This review delineates the connection between environmental factors such as infections leading to gut dysbiosis and NCDs and explores the evidence regarding possible causal link between them. We also discuss the evidence regarding the value of appropriate therapeutic immunomodulatory nutritional interventions to reduce the development of such diseases. We behold such immunomodulatory effects have the potential to influence in various NCDs and restore homeostasis. We believe that the beginning of the era of microbiota-oriented personalized treatment modalities is not far away.https://www.frontiersin.org/articles/10.3389/fnut.2022.966152/fullgut microbiotadysbiosisNCDsimmunomodulatory nutritional interventionprobiotics |
| spellingShingle | Abhiram Kumar Abhiram Kumar Kalyani Sakhare Dwaipayan Bhattacharya Raktim Chattopadhyay Purvish Parikh Kumar P. Narayan Anubhab Mukherjee Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management Frontiers in Nutrition gut microbiota dysbiosis NCDs immunomodulatory nutritional intervention probiotics |
| title | Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management |
| title_full | Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management |
| title_fullStr | Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management |
| title_full_unstemmed | Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management |
| title_short | Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management |
| title_sort | communication in non communicable diseases ncds and role of immunomodulatory nutraceuticals in their management |
| topic | gut microbiota dysbiosis NCDs immunomodulatory nutritional intervention probiotics |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.966152/full |
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