Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated
The rivastigmine patch is the only existing transdermal delivery system used for the treatment of Alzheimer disease. Among the most common adverse events derived from its use are gastrointestinal events, particularly diarrhea. We report a clinical case of an 81-year-old patient admitted to our hospi...
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| Format: | Article |
| Language: | English |
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Korea Geriatrics Society
2023-03-01
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| Series: | Annals of Geriatric Medicine and Research |
| Subjects: | |
| Online Access: | http://www.e-agmr.org/upload/pdf/agmr-22-0116.pdf |
| _version_ | 1797852021192130560 |
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| author | Raffaele Pagliuca Mario Virgilio Papa Pagliuca Mena Ilaria Virginia Federica Papa Gina Varricchio |
| author_facet | Raffaele Pagliuca Mario Virgilio Papa Pagliuca Mena Ilaria Virginia Federica Papa Gina Varricchio |
| author_sort | Raffaele Pagliuca |
| collection | DOAJ |
| description | The rivastigmine patch is the only existing transdermal delivery system used for the treatment of Alzheimer disease. Among the most common adverse events derived from its use are gastrointestinal events, particularly diarrhea. We report a clinical case of an 81-year-old patient admitted to our hospital under long-standing treatment with rivastigmine transdermal patch who presented with atypical watery diarrhea. Anamnesis showed that the patient presented with a likely infectious gastroenteric event, the diarrheal symptoms of which persisted upon resolution of the event and resolved only upon temporary discontinuation of acetylcholinesterase inhibitors. Failure to rapidly identify the causes of profuse diarrhea in older adults can have lethal consequences. When these symptoms occur, quickly recognizing the causes and providing proper management can be lifesaving. |
| first_indexed | 2024-04-09T19:27:17Z |
| format | Article |
| id | doaj.art-0103d70661a242ecb3394b6566efc5b0 |
| institution | Directory Open Access Journal |
| issn | 2508-4798 2508-4909 |
| language | English |
| last_indexed | 2024-04-09T19:27:17Z |
| publishDate | 2023-03-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj.art-0103d70661a242ecb3394b6566efc5b02023-04-05T06:52:52ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982508-49092023-03-01271838610.4235/agmr.22.01161051Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be UnderestimatedRaffaele Pagliuca0Mario Virgilio Papa1Pagliuca Mena Ilaria2Virginia Federica Papa3Gina Varricchio4 Department of Geriatrics, Azienda Ospedaliera di Rilievo Nazionale Sant’Anna e San Sebastiano di Caserta, Caserta, Italy Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Department of Pharmacist, Azienda Ospedaliera dei Colli Cotugno, Napoli, Italy Department of Mental Health and Substance Dependence, ASL Caserta, Caserta, Italy Department of Geriatrics, Azienda Ospedaliera di Rilievo Nazionale Sant’Anna e San Sebastiano di Caserta, Caserta, ItalyThe rivastigmine patch is the only existing transdermal delivery system used for the treatment of Alzheimer disease. Among the most common adverse events derived from its use are gastrointestinal events, particularly diarrhea. We report a clinical case of an 81-year-old patient admitted to our hospital under long-standing treatment with rivastigmine transdermal patch who presented with atypical watery diarrhea. Anamnesis showed that the patient presented with a likely infectious gastroenteric event, the diarrheal symptoms of which persisted upon resolution of the event and resolved only upon temporary discontinuation of acetylcholinesterase inhibitors. Failure to rapidly identify the causes of profuse diarrhea in older adults can have lethal consequences. When these symptoms occur, quickly recognizing the causes and providing proper management can be lifesaving.http://www.e-agmr.org/upload/pdf/agmr-22-0116.pdfrivastigminecholinesterase inhibitorsdiarrheainfectionsgastroenteritisdementia |
| spellingShingle | Raffaele Pagliuca Mario Virgilio Papa Pagliuca Mena Ilaria Virginia Federica Papa Gina Varricchio Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated Annals of Geriatric Medicine and Research rivastigmine cholinesterase inhibitors diarrhea infections gastroenteritis dementia |
| title | Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated |
| title_full | Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated |
| title_fullStr | Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated |
| title_full_unstemmed | Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated |
| title_short | Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated |
| title_sort | atypical presentation of acetylcholinesterase inhibitor induced diarrhea in older adults with cognitive decline an aspect not to be underestimated |
| topic | rivastigmine cholinesterase inhibitors diarrhea infections gastroenteritis dementia |
| url | http://www.e-agmr.org/upload/pdf/agmr-22-0116.pdf |
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