Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan
Abstract In contrast with global trends, HIV prevalence in Kazakhstan and other Central Asian countries has been rising in recent years. In this study, we analyzed hepatitis B (HBV), hepatitis C (HCV), tuberculosis (TB) and sexually-transmitted (STI) co-infections among 500 HIV positive study partic...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92688-w |
| _version_ | 1818692267403116544 |
|---|---|
| author | Ainur Mukhatayeva Aidana Mustafa Natalya Dzissyuk Alpamys Issanov Bauyrzhan Bayserkin Sten H. Vermund Syed Ali |
| author_facet | Ainur Mukhatayeva Aidana Mustafa Natalya Dzissyuk Alpamys Issanov Bauyrzhan Bayserkin Sten H. Vermund Syed Ali |
| author_sort | Ainur Mukhatayeva |
| collection | DOAJ |
| description | Abstract In contrast with global trends, HIV prevalence in Kazakhstan and other Central Asian countries has been rising in recent years. In this study, we analyzed hepatitis B (HBV), hepatitis C (HCV), tuberculosis (TB) and sexually-transmitted (STI) co-infections among 500 HIV positive study participants recruited from all regions of Kazakhstan. Among our study participants, 27%, 8%, 2%, and 5% were coinfected with, respectively, HCV, TB, HBV, and STI. A considerable proportion of the study participants was also found with triple or quadruple infections of HCV/TB (12%), TB/STI (0.8%), HCV/STI (2%), HCV/HBV (1%), HBV/TB (0.4%), HBV/STI (0.2%), HBV/HCV/TB (0.4%), HBV/HCV/STI (0.2%), or HCV/TB/STI (0.2%). Strong associations were found of certain age groups, duration of HIV infection, and practices of injection drug use and sexual contact with PLWH, with co-infections of HIV/HCV and HIV/TB. The odds of having death was 4.07 times higher with TB/HIV as compared to other co-infections. Co-occurrence of HIV with HCV, HBV, and TB infections among participants of this study highlights the necessity of regular screening for HCV infection among HIV infected patients, together with implementation of vigilant vaccination protocols against HBV and TB. Additionally, persons who inject drugs especially need to be focused for harm reduction efforts that include opiate substitution therapy, needle or syringe exchange programs, regular screening, and increased availability of ART and direct acting antivirals. |
| first_indexed | 2024-12-17T12:55:04Z |
| format | Article |
| id | doaj.art-0103db0e827e41faa2b1146a390adff5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T12:55:04Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0103db0e827e41faa2b1146a390adff52022-12-21T21:47:29ZengNature PortfolioScientific Reports2045-23222021-06-0111111110.1038/s41598-021-92688-wHepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in KazakhstanAinur Mukhatayeva0Aidana Mustafa1Natalya Dzissyuk2Alpamys Issanov3Bauyrzhan Bayserkin4Sten H. Vermund5Syed Ali6Department of Biomedical Sciences, Nazarbayev School of Medicine, Nazarbayev UniversityDepartment of Biomedical Sciences, Nazarbayev School of Medicine, Nazarbayev UniversityKazakh Scientific Center of Dermatology and Infectious DiseasesDepartment of Biomedical Sciences, Nazarbayev School of Medicine, Nazarbayev UniversityKazakh Scientific Center of Dermatology and Infectious DiseasesYale School of Public HealthDepartment of Biomedical Sciences, Nazarbayev School of Medicine, Nazarbayev UniversityAbstract In contrast with global trends, HIV prevalence in Kazakhstan and other Central Asian countries has been rising in recent years. In this study, we analyzed hepatitis B (HBV), hepatitis C (HCV), tuberculosis (TB) and sexually-transmitted (STI) co-infections among 500 HIV positive study participants recruited from all regions of Kazakhstan. Among our study participants, 27%, 8%, 2%, and 5% were coinfected with, respectively, HCV, TB, HBV, and STI. A considerable proportion of the study participants was also found with triple or quadruple infections of HCV/TB (12%), TB/STI (0.8%), HCV/STI (2%), HCV/HBV (1%), HBV/TB (0.4%), HBV/STI (0.2%), HBV/HCV/TB (0.4%), HBV/HCV/STI (0.2%), or HCV/TB/STI (0.2%). Strong associations were found of certain age groups, duration of HIV infection, and practices of injection drug use and sexual contact with PLWH, with co-infections of HIV/HCV and HIV/TB. The odds of having death was 4.07 times higher with TB/HIV as compared to other co-infections. Co-occurrence of HIV with HCV, HBV, and TB infections among participants of this study highlights the necessity of regular screening for HCV infection among HIV infected patients, together with implementation of vigilant vaccination protocols against HBV and TB. Additionally, persons who inject drugs especially need to be focused for harm reduction efforts that include opiate substitution therapy, needle or syringe exchange programs, regular screening, and increased availability of ART and direct acting antivirals.https://doi.org/10.1038/s41598-021-92688-w |
| spellingShingle | Ainur Mukhatayeva Aidana Mustafa Natalya Dzissyuk Alpamys Issanov Bauyrzhan Bayserkin Sten H. Vermund Syed Ali Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan Scientific Reports |
| title | Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan |
| title_full | Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan |
| title_fullStr | Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan |
| title_full_unstemmed | Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan |
| title_short | Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan |
| title_sort | hepatitis b hepatitis c tuberculosis and sexually transmitted infections among hiv positive patients in kazakhstan |
| url | https://doi.org/10.1038/s41598-021-92688-w |
| work_keys_str_mv | AT ainurmukhatayeva hepatitisbhepatitisctuberculosisandsexuallytransmittedinfectionsamonghivpositivepatientsinkazakhstan AT aidanamustafa hepatitisbhepatitisctuberculosisandsexuallytransmittedinfectionsamonghivpositivepatientsinkazakhstan AT natalyadzissyuk hepatitisbhepatitisctuberculosisandsexuallytransmittedinfectionsamonghivpositivepatientsinkazakhstan AT alpamysissanov hepatitisbhepatitisctuberculosisandsexuallytransmittedinfectionsamonghivpositivepatientsinkazakhstan AT bauyrzhanbayserkin hepatitisbhepatitisctuberculosisandsexuallytransmittedinfectionsamonghivpositivepatientsinkazakhstan AT stenhvermund hepatitisbhepatitisctuberculosisandsexuallytransmittedinfectionsamonghivpositivepatientsinkazakhstan AT syedali hepatitisbhepatitisctuberculosisandsexuallytransmittedinfectionsamonghivpositivepatientsinkazakhstan |