Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light Scattering
Hydrogels are cross-linked polymer networks swollen in water. The large solvent content enables hydrogels to have unique physical properties and allows them to be used in diverse applications such as tissue engineering, drug delivery, and absorbents. Gel properties are linked to internal dynamics. W...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/7/394 |
| _version_ | 1797433504268550144 |
|---|---|
| author | Sujata Dhakal Zehao Chen Daniel Estrin Svetlana Morozova |
| author_facet | Sujata Dhakal Zehao Chen Daniel Estrin Svetlana Morozova |
| author_sort | Sujata Dhakal |
| collection | DOAJ |
| description | Hydrogels are cross-linked polymer networks swollen in water. The large solvent content enables hydrogels to have unique physical properties and allows them to be used in diverse applications such as tissue engineering, drug delivery, and absorbents. Gel properties are linked to internal dynamics. While bulk gel dynamics have been studied extensively, how gel networks respond locally to deformation has yet to be understood. Here, poly(vinyl alcohol) (PVA) gels have been stretched to study the effects of deformation on gel dynamics parallel and perpendicular to the stretching direction using dynamic small angle light scattering (DSALS). The implementation of DSALS is described and compared to traditional DLS for PVA gels with different crosslink densities, ranging from 0.75–2%. Despite the orders of magnitude difference in the scattering vector, <i>q</i>, range of the techniques, the dynamics match, and the apparent elastic diffusion coefficient, <i>D</i><sub>A</sub> increases linearly with the crosslink density for unstretched gels at a constant 2 wt% concentration. We observe that the elastic motion depends on the direction of stretch, decreasing perpendicular to stretching and increasing at parallel direction. Using DSALS can therefore be an effective tool to evaluate local hydrogel response to deformation. |
| first_indexed | 2024-03-09T10:17:55Z |
| format | Article |
| id | doaj.art-010517954fe649e1a80d3281d1822acd |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T10:17:55Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-010517954fe649e1a80d3281d1822acd2023-12-01T22:10:42ZengMDPI AGGels2310-28612022-06-018739410.3390/gels8070394Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light ScatteringSujata Dhakal0Zehao Chen1Daniel Estrin2Svetlana Morozova3Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, USAHydrogels are cross-linked polymer networks swollen in water. The large solvent content enables hydrogels to have unique physical properties and allows them to be used in diverse applications such as tissue engineering, drug delivery, and absorbents. Gel properties are linked to internal dynamics. While bulk gel dynamics have been studied extensively, how gel networks respond locally to deformation has yet to be understood. Here, poly(vinyl alcohol) (PVA) gels have been stretched to study the effects of deformation on gel dynamics parallel and perpendicular to the stretching direction using dynamic small angle light scattering (DSALS). The implementation of DSALS is described and compared to traditional DLS for PVA gels with different crosslink densities, ranging from 0.75–2%. Despite the orders of magnitude difference in the scattering vector, <i>q</i>, range of the techniques, the dynamics match, and the apparent elastic diffusion coefficient, <i>D</i><sub>A</sub> increases linearly with the crosslink density for unstretched gels at a constant 2 wt% concentration. We observe that the elastic motion depends on the direction of stretch, decreasing perpendicular to stretching and increasing at parallel direction. Using DSALS can therefore be an effective tool to evaluate local hydrogel response to deformation.https://www.mdpi.com/2310-2861/8/7/394gel dynamicspoly(vinyl alcohol)spatially-resolved |
| spellingShingle | Sujata Dhakal Zehao Chen Daniel Estrin Svetlana Morozova Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light Scattering Gels gel dynamics poly(vinyl alcohol) spatially-resolved |
| title | Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light Scattering |
| title_full | Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light Scattering |
| title_fullStr | Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light Scattering |
| title_full_unstemmed | Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light Scattering |
| title_short | Spatially-Resolved Network Dynamics of Poly(vinyl alcohol) Gels Measured with Dynamic Small Angle Light Scattering |
| title_sort | spatially resolved network dynamics of poly vinyl alcohol gels measured with dynamic small angle light scattering |
| topic | gel dynamics poly(vinyl alcohol) spatially-resolved |
| url | https://www.mdpi.com/2310-2861/8/7/394 |
| work_keys_str_mv | AT sujatadhakal spatiallyresolvednetworkdynamicsofpolyvinylalcoholgelsmeasuredwithdynamicsmallanglelightscattering AT zehaochen spatiallyresolvednetworkdynamicsofpolyvinylalcoholgelsmeasuredwithdynamicsmallanglelightscattering AT danielestrin spatiallyresolvednetworkdynamicsofpolyvinylalcoholgelsmeasuredwithdynamicsmallanglelightscattering AT svetlanamorozova spatiallyresolvednetworkdynamicsofpolyvinylalcoholgelsmeasuredwithdynamicsmallanglelightscattering |