Anakinra Therapy for Non-cancer Inflammatory Diseases

Anakinra Therapy for Non-cancer Inflammatory Diseases

Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory mediators, including prostaglandins, cytokines, and chemokines. IL-1α is constitutively present in endothelial a...

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Bibliographic Details
Main Authors: Giulio Cavalli, Charles A. Dinarello
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
interleukin 1
IL-1β
IL-1α
rheumatology
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01157/full

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