From clinic to lab: Advances in porous titanium-based orthopedic implant research
Solid titanium alloys are extensively employed in orthopedic applications due to their reliable mechanical strength, but the stress shielding phenomenon caused by its high elastic modulus and the disadvantage of lack of bone integration may lead to clinical complications. The design of porous struct...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-05-01
|
| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785424009104 |
| _version_ | 1797200838165266432 |
|---|---|
| author | Yongyue Li Yang Liu Hao Chen Aobo Zhang Yongqi Zhang Jiangbo Zhang Bingpeng Chen Qing Han Jincheng Wang |
| author_facet | Yongyue Li Yang Liu Hao Chen Aobo Zhang Yongqi Zhang Jiangbo Zhang Bingpeng Chen Qing Han Jincheng Wang |
| author_sort | Yongyue Li |
| collection | DOAJ |
| description | Solid titanium alloys are extensively employed in orthopedic applications due to their reliable mechanical strength, but the stress shielding phenomenon caused by its high elastic modulus and the disadvantage of lack of bone integration may lead to clinical complications. The design of porous structure is a feasible approach to reduce the elastic modulus and promote bone and vascular ingrowth. This paper reviewed the application and current challenges of solid titanium implants in orthopedics. To address the drawbacks and explore porous titanium implants that can effectively integrate with bone tissue while possessing sufficient mechanical strength, this review discussed the latest preclinical research from the perspectives of structural design, surface modification, and material composition. The porous structure parameters that affect bone ingrowth and mechanical strength in implants, including porosity, pore size, cellular structure, and gradient structure, were presented. Based on the current research progress, various surface modification techniques aimed at enhancing the performance of porous titanium implants were overviewed. Moreover, a range of titanium alloys including nickel-titanium alloy, β-titanium alloy, high-entropy alloy, and composite alloys are investigated for their prospective applications in orthopedics. Overall, this review provided valuable insights into the current state of research and highlighted the potential of porous titanium alloys in improving clinical outcomes in orthopedics. |
| first_indexed | 2024-04-24T07:38:00Z |
| format | Article |
| id | doaj.art-0105e591d12c4f919213f5a24d19a829 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-04-24T07:38:00Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-0105e591d12c4f919213f5a24d19a8292024-04-20T04:17:29ZengElsevierJournal of Materials Research and Technology2238-78542024-05-013037803806From clinic to lab: Advances in porous titanium-based orthopedic implant researchYongyue Li0Yang Liu1Hao Chen2Aobo Zhang3Yongqi Zhang4Jiangbo Zhang5Bingpeng Chen6Qing Han7Jincheng Wang8Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Nephrology and Rheumatology, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, China; Corresponding author.Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, China; Corresponding author.Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaSolid titanium alloys are extensively employed in orthopedic applications due to their reliable mechanical strength, but the stress shielding phenomenon caused by its high elastic modulus and the disadvantage of lack of bone integration may lead to clinical complications. The design of porous structure is a feasible approach to reduce the elastic modulus and promote bone and vascular ingrowth. This paper reviewed the application and current challenges of solid titanium implants in orthopedics. To address the drawbacks and explore porous titanium implants that can effectively integrate with bone tissue while possessing sufficient mechanical strength, this review discussed the latest preclinical research from the perspectives of structural design, surface modification, and material composition. The porous structure parameters that affect bone ingrowth and mechanical strength in implants, including porosity, pore size, cellular structure, and gradient structure, were presented. Based on the current research progress, various surface modification techniques aimed at enhancing the performance of porous titanium implants were overviewed. Moreover, a range of titanium alloys including nickel-titanium alloy, β-titanium alloy, high-entropy alloy, and composite alloys are investigated for their prospective applications in orthopedics. Overall, this review provided valuable insights into the current state of research and highlighted the potential of porous titanium alloys in improving clinical outcomes in orthopedics.http://www.sciencedirect.com/science/article/pii/S2238785424009104Porous structuresImplantSurface modificationTitanium alloyBone growth |
| spellingShingle | Yongyue Li Yang Liu Hao Chen Aobo Zhang Yongqi Zhang Jiangbo Zhang Bingpeng Chen Qing Han Jincheng Wang From clinic to lab: Advances in porous titanium-based orthopedic implant research Journal of Materials Research and Technology Porous structures Implant Surface modification Titanium alloy Bone growth |
| title | From clinic to lab: Advances in porous titanium-based orthopedic implant research |
| title_full | From clinic to lab: Advances in porous titanium-based orthopedic implant research |
| title_fullStr | From clinic to lab: Advances in porous titanium-based orthopedic implant research |
| title_full_unstemmed | From clinic to lab: Advances in porous titanium-based orthopedic implant research |
| title_short | From clinic to lab: Advances in porous titanium-based orthopedic implant research |
| title_sort | from clinic to lab advances in porous titanium based orthopedic implant research |
| topic | Porous structures Implant Surface modification Titanium alloy Bone growth |
| url | http://www.sciencedirect.com/science/article/pii/S2238785424009104 |
| work_keys_str_mv | AT yongyueli fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT yangliu fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT haochen fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT aobozhang fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT yongqizhang fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT jiangbozhang fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT bingpengchen fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT qinghan fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch AT jinchengwang fromclinictolabadvancesinporoustitaniumbasedorthopedicimplantresearch |