T315I – a gatekeeper point mutation and its impact on the prognosis of chronic myeloid leukemia

T315I – a gatekeeper point mutation and its impact on the prognosis of chronic myeloid leukemia

BCR-ABL kinase domain mutations are an important cause of resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukaemia (CML) of which T315I is the most treatment-resilient. This study aimed to observe the frequency of T315I and its impact on disease prognosis in terms of progression...

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Bibliographic Details
Main Authors: Kaleem Bushra, Shahab Sadaf, Shamsi Tahir Sultan
Format: Article
Language:English
Published: De Gruyter 2024-09-01
Series:Advances in Laboratory Medicine
Subjects:
bcr-abl
chronic myeloid leukaemia (cml)
disease progression
overall survival
resistance
t315i mutation
Online Access:https://doi.org/10.1515/almed-2024-0069

Internet

https://doi.org/10.1515/almed-2024-0069

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