Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining
BackgroundPeri‐stent contrast staining (PSS) after metallic drug‐eluting stent deployment is associated with target lesion revascularization and very late stent thrombosis. However, the type of PSS that influences the clinical outcomes is unknown. Therefore, we aimed to reveal which PSS type was inf...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-03-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.115.002878 |
| _version_ | 1811275109992759296 |
|---|---|
| author | Takahiro Tokuda Masahiro Yamawaki Mitsuyohi Takahara Shinsuke Mori Kenji Makino Yosuke Honda Hiroya Takafuji Takuro Takama Masakazu Tsutsumi Yasunari Sakamoto Hideyuki Takimura Norihiro Kobayashi Motoharu Araki Keisuke Hirano Yoshiaki Ito |
| author_facet | Takahiro Tokuda Masahiro Yamawaki Mitsuyohi Takahara Shinsuke Mori Kenji Makino Yosuke Honda Hiroya Takafuji Takuro Takama Masakazu Tsutsumi Yasunari Sakamoto Hideyuki Takimura Norihiro Kobayashi Motoharu Araki Keisuke Hirano Yoshiaki Ito |
| author_sort | Takahiro Tokuda |
| collection | DOAJ |
| description | BackgroundPeri‐stent contrast staining (PSS) after metallic drug‐eluting stent deployment is associated with target lesion revascularization and very late stent thrombosis. However, the type of PSS that influences the clinical outcomes is unknown. Therefore, we aimed to reveal which PSS type was influencing clinical outcomes. Methods and ResultsThis study included 5580 de novo lesions of 4405 patients who were implanted with a first‐ or second‐generation drug‐eluting stent and who were evaluated using follow‐up angiography within 12 months after stent implantation. We compared the clinical outcomes of patients divided into focal PSS and segmental PSS groups for 6 years after stent implantation. Total PSS was observed in 97 lesions (2.2%), of which 42 and 55 lesions were focal and segmental PSS, respectively. Baseline characteristics were similar between groups, except for intraoperative chronic total occlusion (segmental PSS=47.3% versus focal PSS=11.9%, P=0.0001). The incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent (83.6% versus 16.4%, P=0.05). The cumulative incidence of stent thrombosis in the 6 years of segmental PSS group was significantly higher than that of the focal PSS group (13.9% versus 0%, P=0.04). The cumulative incidence of overall target lesion revascularization for restenosis, excluding target lesion revascularization procedures for stent thrombosis, was significantly higher in the segmental PSS group (38.0% versus 0%, P=0.01). ConclusionsThe incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent and appeared to be significantly associated with target lesion revascularization and stent thrombosis. |
| first_indexed | 2024-04-12T23:32:13Z |
| format | Article |
| id | doaj.art-0107e9371a864505b8f0e6b8f751f317 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-12T23:32:13Z |
| publishDate | 2016-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-0107e9371a864505b8f0e6b8f751f3172022-12-22T03:12:14ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-03-015310.1161/JAHA.115.002878Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast StainingTakahiro Tokuda0Masahiro Yamawaki1Mitsuyohi Takahara2Shinsuke Mori3Kenji Makino4Yosuke Honda5Hiroya Takafuji6Takuro Takama7Masakazu Tsutsumi8Yasunari Sakamoto9Hideyuki Takimura10Norihiro Kobayashi11Motoharu Araki12Keisuke Hirano13Yoshiaki Ito14Department of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Diabetes Care Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiovascular Medicine, Saiseikai Yokohama City Eastern Hospital, Yokohama, Kanagawa, JapanBackgroundPeri‐stent contrast staining (PSS) after metallic drug‐eluting stent deployment is associated with target lesion revascularization and very late stent thrombosis. However, the type of PSS that influences the clinical outcomes is unknown. Therefore, we aimed to reveal which PSS type was influencing clinical outcomes. Methods and ResultsThis study included 5580 de novo lesions of 4405 patients who were implanted with a first‐ or second‐generation drug‐eluting stent and who were evaluated using follow‐up angiography within 12 months after stent implantation. We compared the clinical outcomes of patients divided into focal PSS and segmental PSS groups for 6 years after stent implantation. Total PSS was observed in 97 lesions (2.2%), of which 42 and 55 lesions were focal and segmental PSS, respectively. Baseline characteristics were similar between groups, except for intraoperative chronic total occlusion (segmental PSS=47.3% versus focal PSS=11.9%, P=0.0001). The incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent (83.6% versus 16.4%, P=0.05). The cumulative incidence of stent thrombosis in the 6 years of segmental PSS group was significantly higher than that of the focal PSS group (13.9% versus 0%, P=0.04). The cumulative incidence of overall target lesion revascularization for restenosis, excluding target lesion revascularization procedures for stent thrombosis, was significantly higher in the segmental PSS group (38.0% versus 0%, P=0.01). ConclusionsThe incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent and appeared to be significantly associated with target lesion revascularization and stent thrombosis.https://www.ahajournals.org/doi/10.1161/JAHA.115.002878peri‐stent contrast stainingsegmental peri‐stent contrast stainingstent thrombosis |
| spellingShingle | Takahiro Tokuda Masahiro Yamawaki Mitsuyohi Takahara Shinsuke Mori Kenji Makino Yosuke Honda Hiroya Takafuji Takuro Takama Masakazu Tsutsumi Yasunari Sakamoto Hideyuki Takimura Norihiro Kobayashi Motoharu Araki Keisuke Hirano Yoshiaki Ito Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease peri‐stent contrast staining segmental peri‐stent contrast staining stent thrombosis |
| title | Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining |
| title_full | Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining |
| title_fullStr | Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining |
| title_full_unstemmed | Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining |
| title_short | Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining |
| title_sort | comparison of long term clinical outcomes of lesions exhibiting focal and segmental peri stent contrast staining |
| topic | peri‐stent contrast staining segmental peri‐stent contrast staining stent thrombosis |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.115.002878 |
| work_keys_str_mv | AT takahirotokuda comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT masahiroyamawaki comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT mitsuyohitakahara comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT shinsukemori comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT kenjimakino comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT yosukehonda comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT hiroyatakafuji comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT takurotakama comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT masakazutsutsumi comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT yasunarisakamoto comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT hideyukitakimura comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT norihirokobayashi comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT motoharuaraki comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT keisukehirano comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining AT yoshiakiito comparisonoflongtermclinicaloutcomesoflesionsexhibitingfocalandsegmentalperistentcontraststaining |