The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats
The leaf and twig aqueous extracts of Arabian balsam tree (Commiphora gileadensis) were tested to protect against alloxan-induced hyperglycaemia in hypercholesterolemic male rats. The antioxidants, high density lipoproteins, IgE and α-Amylase were decreased, whereas kidney function indices, liver fu...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Journal of Taibah University for Science |
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| Online Access: | http://dx.doi.org/10.1080/16583655.2020.1780020 |
| _version_ | 1818950223182954496 |
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| author | Haddad A. El Rabey Abdulbasit I. Al-Sieni Madeha N. Al-Seeni Mohammed A. Alsieni Adel I. Alalawy Fahad M. Almutairi |
| author_facet | Haddad A. El Rabey Abdulbasit I. Al-Sieni Madeha N. Al-Seeni Mohammed A. Alsieni Adel I. Alalawy Fahad M. Almutairi |
| author_sort | Haddad A. El Rabey |
| collection | DOAJ |
| description | The leaf and twig aqueous extracts of Arabian balsam tree (Commiphora gileadensis) were tested to protect against alloxan-induced hyperglycaemia in hypercholesterolemic male rats. The antioxidants, high density lipoproteins, IgE and α-Amylase were decreased, whereas kidney function indices, liver function enzymes, triglycerides, cholesterol, low density lipoproteins and all immunoglobulins except IgE were increased as a result of alloxan administration. Moreover, the renal, hepatic and pancreatic tissue showed a drastic pathological damage. In G3 and G4, treating the diabetic rats with C. gileadensis leaf and twig extracts, respectively greatly ameliorated all biochemical parameters and the injured tissues and restored them nearly to the normal. In G4, the aqueous extract of C. gileadensis twig was more efficient in treating the diabetic rats than the leaf aqueous extract in G3. Both C. gileadensis leaf and twig aqueous extracts succeeded in adjusting the glucose levels of diabetic rats under hypercholesterolemic condition due to their antioxidant activity. |
| first_indexed | 2024-12-20T09:15:10Z |
| format | Article |
| id | doaj.art-010ee5940c62441eabd90765782babb3 |
| institution | Directory Open Access Journal |
| issn | 1658-3655 |
| language | English |
| last_indexed | 2024-12-20T09:15:10Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj.art-010ee5940c62441eabd90765782babb32022-12-21T19:45:25ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552020-01-0114183184110.1080/16583655.2020.17800201780020The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male ratsHaddad A. El Rabey0Abdulbasit I. Al-Sieni1Madeha N. Al-Seeni2Mohammed A. Alsieni3Adel I. Alalawy4Fahad M. Almutairi5Biochemistry Department, Faculty of Science, University of TabukBiochemistry Department, Faculty of Science, King Abdulaziz UniversityBiochemistry Department, Faculty of Science, King Abdulaziz UniversityPharmacology Department, Faculty of Medicine, King Abdulaziz UniversityBiochemistry Department, Faculty of Science, University of TabukBiochemistry Department, Faculty of Science, University of TabukThe leaf and twig aqueous extracts of Arabian balsam tree (Commiphora gileadensis) were tested to protect against alloxan-induced hyperglycaemia in hypercholesterolemic male rats. The antioxidants, high density lipoproteins, IgE and α-Amylase were decreased, whereas kidney function indices, liver function enzymes, triglycerides, cholesterol, low density lipoproteins and all immunoglobulins except IgE were increased as a result of alloxan administration. Moreover, the renal, hepatic and pancreatic tissue showed a drastic pathological damage. In G3 and G4, treating the diabetic rats with C. gileadensis leaf and twig extracts, respectively greatly ameliorated all biochemical parameters and the injured tissues and restored them nearly to the normal. In G4, the aqueous extract of C. gileadensis twig was more efficient in treating the diabetic rats than the leaf aqueous extract in G3. Both C. gileadensis leaf and twig aqueous extracts succeeded in adjusting the glucose levels of diabetic rats under hypercholesterolemic condition due to their antioxidant activity.http://dx.doi.org/10.1080/16583655.2020.1780020alloxanratcommiphora gileadensisantidiabeticantioxidanthypolipidemic |
| spellingShingle | Haddad A. El Rabey Abdulbasit I. Al-Sieni Madeha N. Al-Seeni Mohammed A. Alsieni Adel I. Alalawy Fahad M. Almutairi The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats Journal of Taibah University for Science alloxan rat commiphora gileadensis antidiabetic antioxidant hypolipidemic |
| title | The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats |
| title_full | The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats |
| title_fullStr | The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats |
| title_full_unstemmed | The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats |
| title_short | The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats |
| title_sort | antioxidant and antidiabetic activity of the arabian balsam tree commiphora gileadensis in hyperlipidaemic male rats |
| topic | alloxan rat commiphora gileadensis antidiabetic antioxidant hypolipidemic |
| url | http://dx.doi.org/10.1080/16583655.2020.1780020 |
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