Causes of death after testicular cancer diagnosis: a US population-based analysis
Abstract Background After the introduction of cisplatin-based chemotherapy, the survival time of testicular cancer (TC) patients has improved dramatically. However, the overall risk of death in patients with TC remains significantly higher than in the general population. The aim of this study was to...
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| Format: | Article |
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BMC
2023-09-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-023-01309-3 |
| _version_ | 1797451309907968000 |
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| author | Zhongyuan Wang Baochao Li Jiajun Xing Zixuan Gong Aiming Xu Zengjun Wang |
| author_facet | Zhongyuan Wang Baochao Li Jiajun Xing Zixuan Gong Aiming Xu Zengjun Wang |
| author_sort | Zhongyuan Wang |
| collection | DOAJ |
| description | Abstract Background After the introduction of cisplatin-based chemotherapy, the survival time of testicular cancer (TC) patients has improved dramatically. However, the overall risk of death in patients with TC remains significantly higher than in the general population. The aim of this study was to assess and quantify the causes of death after TC diagnosis. Method In total, 44,975 men with TC in the United States diagnosed and registered by the Surveillance, Epidemiology, and End Results (SEER) database during 2000 to 2018 were studied. In this study, standardized mortality rates (SMRs) were calculated for each cause of death in TC individuals and further analyzed in strata according to age and race. Result Of the included participants, 3,573 (7.94%) died during the follow-up period. The greatest proportion of deaths (38.20%) occurred within 1 to 5 years after diagnosis. Most deaths occurred from TC itself and other cancers. For non-malignant conditions, the most common causes of death within 1 years after diagnosis were accidents and adverse effects (53, 4.75%) followed by diseases of heart (45, 4.04%). However, > 1 years after diagnosis, the most common noncancer causes of death were heart diseases. Results of stratified analysis show that non-Hispanic White TC participants have a lower SMR (0.68, 95% CI, 33.39–38.67) from Cerebrovascular Diseases than the general U.S. population. Conclusions Although TC remains the most common cause of death after TC diagnosis, other non-TC causes of death represent a significant number of deaths among TC men. These findings help TC survivors understand the various health risks that may occur at different follow-up periods. |
| first_indexed | 2024-03-09T14:52:50Z |
| format | Article |
| id | doaj.art-010f1f69e065427a9bc48d31c86ecaab |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-03-09T14:52:50Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-010f1f69e065427a9bc48d31c86ecaab2023-11-26T14:20:47ZengBMCBMC Urology1471-24902023-09-0123111210.1186/s12894-023-01309-3Causes of death after testicular cancer diagnosis: a US population-based analysisZhongyuan Wang0Baochao Li1Jiajun Xing2Zixuan Gong3Aiming Xu4Zengjun Wang5Department of Urology, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, First Affiliated Hospital of Nanjing Medical UniversityAbstract Background After the introduction of cisplatin-based chemotherapy, the survival time of testicular cancer (TC) patients has improved dramatically. However, the overall risk of death in patients with TC remains significantly higher than in the general population. The aim of this study was to assess and quantify the causes of death after TC diagnosis. Method In total, 44,975 men with TC in the United States diagnosed and registered by the Surveillance, Epidemiology, and End Results (SEER) database during 2000 to 2018 were studied. In this study, standardized mortality rates (SMRs) were calculated for each cause of death in TC individuals and further analyzed in strata according to age and race. Result Of the included participants, 3,573 (7.94%) died during the follow-up period. The greatest proportion of deaths (38.20%) occurred within 1 to 5 years after diagnosis. Most deaths occurred from TC itself and other cancers. For non-malignant conditions, the most common causes of death within 1 years after diagnosis were accidents and adverse effects (53, 4.75%) followed by diseases of heart (45, 4.04%). However, > 1 years after diagnosis, the most common noncancer causes of death were heart diseases. Results of stratified analysis show that non-Hispanic White TC participants have a lower SMR (0.68, 95% CI, 33.39–38.67) from Cerebrovascular Diseases than the general U.S. population. Conclusions Although TC remains the most common cause of death after TC diagnosis, other non-TC causes of death represent a significant number of deaths among TC men. These findings help TC survivors understand the various health risks that may occur at different follow-up periods.https://doi.org/10.1186/s12894-023-01309-3Testicular cancerCancer survivorshipCauses of deathSurveillance, Epidemiology, and End Results (SEER)Database |
| spellingShingle | Zhongyuan Wang Baochao Li Jiajun Xing Zixuan Gong Aiming Xu Zengjun Wang Causes of death after testicular cancer diagnosis: a US population-based analysis BMC Urology Testicular cancer Cancer survivorship Causes of death Surveillance, Epidemiology, and End Results (SEER) Database |
| title | Causes of death after testicular cancer diagnosis: a US population-based analysis |
| title_full | Causes of death after testicular cancer diagnosis: a US population-based analysis |
| title_fullStr | Causes of death after testicular cancer diagnosis: a US population-based analysis |
| title_full_unstemmed | Causes of death after testicular cancer diagnosis: a US population-based analysis |
| title_short | Causes of death after testicular cancer diagnosis: a US population-based analysis |
| title_sort | causes of death after testicular cancer diagnosis a us population based analysis |
| topic | Testicular cancer Cancer survivorship Causes of death Surveillance, Epidemiology, and End Results (SEER) Database |
| url | https://doi.org/10.1186/s12894-023-01309-3 |
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