Motor Abnormalities, Depression Risk, and Clinical Course in Adolescence
Background: Motor abnormalities, such as psychomotor agitation and retardation, are widely recognized as core features of depression. However, it is not currently known whether motor abnormalities connote risk for depression. Methods: Using data from the Adolescent Brain Cognitive Development (ABCD)...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Biological Psychiatry Global Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174321000574 |
| _version_ | 1798026140695134208 |
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| author | Katherine S.F. Damme Jadyn S. Park Teresa Vargas Sebastian Walther Stewart A. Shankman Vijay A. Mittal |
| author_facet | Katherine S.F. Damme Jadyn S. Park Teresa Vargas Sebastian Walther Stewart A. Shankman Vijay A. Mittal |
| author_sort | Katherine S.F. Damme |
| collection | DOAJ |
| description | Background: Motor abnormalities, such as psychomotor agitation and retardation, are widely recognized as core features of depression. However, it is not currently known whether motor abnormalities connote risk for depression. Methods: Using data from the Adolescent Brain Cognitive Development (ABCD) Study, a nationally representative sample of youth (N = 10,835, 9–11 years old), the present paper examines whether motor abnormalities are associated with 1) depression symptoms in early adolescence, 2) familial risk for depression (familial risk loading), and 3) future depression symptoms. Motor abnormality measures included traditional (DSM) motor signs such as psychomotor agitation and retardation as well as other motor domains such as developmental motor delays and dyscoordination. Results: Traditional motor abnormalities were less prevalent (agitation = 3.2%, retardation = 0.3%) than nontraditional domains (delays = 13.79%, coordination = 35.5%) among adolescents. Motor dysfunction was associated with depression symptoms (Cohen’s d = 0.02 to 0.12). Familial risk for depression was related to motor abnormalities (Cohen’s d = 0.08 to 0.27), with the exception of motor retardation. Family vulnerability varied in sensitivity to depression risk (e.g., retardation: 0.53%; dyscoordination: 32.05%). Baseline endorsement of motor abnormalities predicted future depression symptoms at 1-year follow-up. Conclusions: These findings suggest that motor signs reflect a novel, promising future direction for examining vulnerability to depression risk in early adolescence. |
| first_indexed | 2024-04-11T18:31:35Z |
| format | Article |
| id | doaj.art-0110d1a6b5c7452a85b1c16e7effcdcc |
| institution | Directory Open Access Journal |
| issn | 2667-1743 |
| language | English |
| last_indexed | 2024-04-11T18:31:35Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj.art-0110d1a6b5c7452a85b1c16e7effcdcc2022-12-22T04:09:26ZengElsevierBiological Psychiatry Global Open Science2667-17432022-01-01216169Motor Abnormalities, Depression Risk, and Clinical Course in AdolescenceKatherine S.F. Damme0Jadyn S. Park1Teresa Vargas2Sebastian Walther3Stewart A. Shankman4Vijay A. Mittal5Department of Psychology, Northwestern University, Evanston, Illinois; Institute for Innovations in Developmental Sciences, Northwestern University, Evanston and Chicago, Illinois; Address correspondence to Katherine S.F. Damme, Ph.D.Department of Psychology, Northwestern University, Evanston, Illinois; Department of Psychiatry, Northwestern University, Chicago, IllinoisDepartment of Psychology, Northwestern University, Evanston, Illinois; Institute for Innovations in Developmental Sciences, Northwestern University, Evanston and Chicago, IllinoisTranslational Research Center, University Hospital of Psychiatry, University of Bern, Bern, SwitzerlandDepartment of Psychology, Northwestern University, Evanston, Illinois; Institute for Innovations in Developmental Sciences, Northwestern University, Evanston and Chicago, Illinois; Department of Psychiatry, Northwestern University, Chicago, IllinoisDepartment of Psychology, Northwestern University, Evanston, Illinois; Institute for Innovations in Developmental Sciences, Northwestern University, Evanston and Chicago, Illinois; Medical Social Sciences, Northwestern University, Chicago, Illinois; Institute for Policy Research, Northwestern University, Chicago, IllinoisBackground: Motor abnormalities, such as psychomotor agitation and retardation, are widely recognized as core features of depression. However, it is not currently known whether motor abnormalities connote risk for depression. Methods: Using data from the Adolescent Brain Cognitive Development (ABCD) Study, a nationally representative sample of youth (N = 10,835, 9–11 years old), the present paper examines whether motor abnormalities are associated with 1) depression symptoms in early adolescence, 2) familial risk for depression (familial risk loading), and 3) future depression symptoms. Motor abnormality measures included traditional (DSM) motor signs such as psychomotor agitation and retardation as well as other motor domains such as developmental motor delays and dyscoordination. Results: Traditional motor abnormalities were less prevalent (agitation = 3.2%, retardation = 0.3%) than nontraditional domains (delays = 13.79%, coordination = 35.5%) among adolescents. Motor dysfunction was associated with depression symptoms (Cohen’s d = 0.02 to 0.12). Familial risk for depression was related to motor abnormalities (Cohen’s d = 0.08 to 0.27), with the exception of motor retardation. Family vulnerability varied in sensitivity to depression risk (e.g., retardation: 0.53%; dyscoordination: 32.05%). Baseline endorsement of motor abnormalities predicted future depression symptoms at 1-year follow-up. Conclusions: These findings suggest that motor signs reflect a novel, promising future direction for examining vulnerability to depression risk in early adolescence.http://www.sciencedirect.com/science/article/pii/S2667174321000574AdolescenceClinical riskDepressionDevelopmentFamilial riskMotor |
| spellingShingle | Katherine S.F. Damme Jadyn S. Park Teresa Vargas Sebastian Walther Stewart A. Shankman Vijay A. Mittal Motor Abnormalities, Depression Risk, and Clinical Course in Adolescence Biological Psychiatry Global Open Science Adolescence Clinical risk Depression Development Familial risk Motor |
| title | Motor Abnormalities, Depression Risk, and Clinical Course in Adolescence |
| title_full | Motor Abnormalities, Depression Risk, and Clinical Course in Adolescence |
| title_fullStr | Motor Abnormalities, Depression Risk, and Clinical Course in Adolescence |
| title_full_unstemmed | Motor Abnormalities, Depression Risk, and Clinical Course in Adolescence |
| title_short | Motor Abnormalities, Depression Risk, and Clinical Course in Adolescence |
| title_sort | motor abnormalities depression risk and clinical course in adolescence |
| topic | Adolescence Clinical risk Depression Development Familial risk Motor |
| url | http://www.sciencedirect.com/science/article/pii/S2667174321000574 |
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