The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges

<p>Traumatic brain injury (TBI) is a focal injury with limited reliable treatment options. Despite the large volume of basic research into TBI (particularly on the complex pathophysiology and on the application of various techniques), the treatment of TBI currently remains a challenge due to t...

Full description

Bibliographic Details
Main Authors: Cui Lianxu, Yasmeen Saeed, Li Haomin, Yang Jingli
Format: Article
Language:English
Published: Discover STM Publishing Ltd 2022-03-01
Series:BioMedica
Online Access:https://biomedicapk.com/10.51441/BioMedica/5-498
_version_ 1797629318327697408
author Cui Lianxu
Yasmeen Saeed
Li Haomin
Yang Jingli
author_facet Cui Lianxu
Yasmeen Saeed
Li Haomin
Yang Jingli
author_sort Cui Lianxu
collection DOAJ
description <p>Traumatic brain injury (TBI) is a focal injury with limited reliable treatment options. Despite the large volume of basic research into TBI (particularly on the complex pathophysiology and on the application of various techniques), the treatment of TBI currently remains a challenge due to the low efficacy of available therapeutic options. Recent studies have shown that stem cells possess the ability to aid in recovery from the damaging effects of the craniocerebral injury. Herein, we attempted to present a generalized critique for the role of mesenchymal stem cell therapy in TBI, its underlying mechanisms, and the scope for improvements in TBI treatment identified through preclinical studies, clinical studies, and other research in the light of previously reported literature. Finally, we summarized some novel strategies to overcome the clinical challenges in TBI recovery. Collectively, the major objective of this review is to highlight the to-date available findings regarding role of stem cell therapy in TBI and pave the way for the development of safe and efficient regenerative treatment modalities for TBI by comprehensive understanding the specific mechanism.</p>
first_indexed 2024-03-11T10:52:43Z
format Article
id doaj.art-011151b5d8a6447f93232b986e2b8527
institution Directory Open Access Journal
issn 2710-3471
language English
last_indexed 2024-03-11T10:52:43Z
publishDate 2022-03-01
publisher Discover STM Publishing Ltd
record_format Article
series BioMedica
spelling doaj.art-011151b5d8a6447f93232b986e2b85272023-11-13T14:11:39ZengDiscover STM Publishing LtdBioMedica2710-34712022-03-0137313914710.51441/BioMedica/5-498The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical ChallengesCui Lianxu0Yasmeen Saeed1Li Haomin2Yang Jingli3Department of Neurosurgery, The First People’s Hospital of Foshan, No.81 North Lingnan Road, Foshan, Guangdong - PR China.Guangdong VitaLife Biotechnology Co., LTD, No. 61 Xiannan Road, Nanhai District, Foshan, Guangdong - PR China.Department of Neurosurgery, The First People’s Hospital of Foshan, No.81 North Lingnan Road, Foshan, Guangdong - PR China.School of Medicine, Foshan University, 18 Jiangwan Road, Foshan, Guangdong -PR China.<p>Traumatic brain injury (TBI) is a focal injury with limited reliable treatment options. Despite the large volume of basic research into TBI (particularly on the complex pathophysiology and on the application of various techniques), the treatment of TBI currently remains a challenge due to the low efficacy of available therapeutic options. Recent studies have shown that stem cells possess the ability to aid in recovery from the damaging effects of the craniocerebral injury. Herein, we attempted to present a generalized critique for the role of mesenchymal stem cell therapy in TBI, its underlying mechanisms, and the scope for improvements in TBI treatment identified through preclinical studies, clinical studies, and other research in the light of previously reported literature. Finally, we summarized some novel strategies to overcome the clinical challenges in TBI recovery. Collectively, the major objective of this review is to highlight the to-date available findings regarding role of stem cell therapy in TBI and pave the way for the development of safe and efficient regenerative treatment modalities for TBI by comprehensive understanding the specific mechanism.</p>https://biomedicapk.com/10.51441/BioMedica/5-498
spellingShingle Cui Lianxu
Yasmeen Saeed
Li Haomin
Yang Jingli
The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges
BioMedica
title The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges
title_full The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges
title_fullStr The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges
title_full_unstemmed The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges
title_short The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges
title_sort role of mesenchymal stem cell therapy in traumatic brain injury a review from basic research to clinical challenges
url https://biomedicapk.com/10.51441/BioMedica/5-498
work_keys_str_mv AT cuilianxu theroleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges
AT yasmeensaeed theroleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges
AT lihaomin theroleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges
AT yangjingli theroleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges
AT cuilianxu roleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges
AT yasmeensaeed roleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges
AT lihaomin roleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges
AT yangjingli roleofmesenchymalstemcelltherapyintraumaticbraininjuryareviewfrombasicresearchtoclinicalchallenges