Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams
In this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, a pencil-beam model with a triple Gaussian form for the lateral-dose distribution, and a beam sp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089877/?tool=EBI |
| _version_ | 1818232195114860544 |
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| author | Masashi Yagi Toshiro Tsubouchi Noriaki Hamatani Masaaki Takashina Hiroyasu Maruo Shinichiro Fujitaka Hideaki Nihongi Kazuhiko Ogawa Tatsuaki Kanai |
| author_facet | Masashi Yagi Toshiro Tsubouchi Noriaki Hamatani Masaaki Takashina Hiroyasu Maruo Shinichiro Fujitaka Hideaki Nihongi Kazuhiko Ogawa Tatsuaki Kanai |
| author_sort | Masashi Yagi |
| collection | DOAJ |
| description | In this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, a pencil-beam model with a triple Gaussian form for the lateral-dose distribution, and a beam splitting algorithm to consider lateral heterogeneity in a medium. We adopted the mixed beam model as the relative biological effectiveness (RBE) model for calculating the RBE values of the scanned carbon-ion beam. To validate the modeled physical dose, we compared the calculations with measurements of various relevant quantities as functions of the field size, range and width of the spread-out Bragg peak (SOBP), and depth–dose and lateral-dose profiles for a 6-mm SOBP in water. To model the biological dose, we compared the RBE calculated with the newly developed TPS to the RBE calculated with a previously validated TPS that is in clinical use and uses the same RBE model concept. We also performed patient-specific measurements to validate the dose model in clinical situations. The physical beam model reproduces the measured absolute dose at the center of the SOBP as a function of field size, range, and SOBP width and reproduces the dose profiles for a 6-mm SOBP in water. However, the profiles calculated for a heterogeneous phantom have some limitations in predicting the carbon-ion-beam dose, although the biological doses agreed well with the values calculated by the validated TPS. Using this dose model for fast-raster scanning, we successfully treated more than 900 patients from October 2018 to October 2020, with an acceptable agreement between the TPS-calculated and measured dose distributions. We conclude that the newly developed TPS can be used clinically with the understanding that it has limited accuracies for heterogeneous media. |
| first_indexed | 2024-12-12T11:02:25Z |
| format | Article |
| id | doaj.art-01131c0845e74d48a6d00012e1dc0499 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T11:02:25Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-01131c0845e74d48a6d00012e1dc04992022-12-22T00:26:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01175Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beamsMasashi YagiToshiro TsubouchiNoriaki HamataniMasaaki TakashinaHiroyasu MaruoShinichiro FujitakaHideaki NihongiKazuhiko OgawaTatsuaki KanaiIn this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, a pencil-beam model with a triple Gaussian form for the lateral-dose distribution, and a beam splitting algorithm to consider lateral heterogeneity in a medium. We adopted the mixed beam model as the relative biological effectiveness (RBE) model for calculating the RBE values of the scanned carbon-ion beam. To validate the modeled physical dose, we compared the calculations with measurements of various relevant quantities as functions of the field size, range and width of the spread-out Bragg peak (SOBP), and depth–dose and lateral-dose profiles for a 6-mm SOBP in water. To model the biological dose, we compared the RBE calculated with the newly developed TPS to the RBE calculated with a previously validated TPS that is in clinical use and uses the same RBE model concept. We also performed patient-specific measurements to validate the dose model in clinical situations. The physical beam model reproduces the measured absolute dose at the center of the SOBP as a function of field size, range, and SOBP width and reproduces the dose profiles for a 6-mm SOBP in water. However, the profiles calculated for a heterogeneous phantom have some limitations in predicting the carbon-ion-beam dose, although the biological doses agreed well with the values calculated by the validated TPS. Using this dose model for fast-raster scanning, we successfully treated more than 900 patients from October 2018 to October 2020, with an acceptable agreement between the TPS-calculated and measured dose distributions. We conclude that the newly developed TPS can be used clinically with the understanding that it has limited accuracies for heterogeneous media.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089877/?tool=EBI |
| spellingShingle | Masashi Yagi Toshiro Tsubouchi Noriaki Hamatani Masaaki Takashina Hiroyasu Maruo Shinichiro Fujitaka Hideaki Nihongi Kazuhiko Ogawa Tatsuaki Kanai Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams PLoS ONE |
| title | Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams |
| title_full | Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams |
| title_fullStr | Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams |
| title_full_unstemmed | Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams |
| title_short | Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams |
| title_sort | commissioning a newly developed treatment planning system vqa plan for fast raster scanning of carbon ion beams |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089877/?tool=EBI |
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