Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trials
The clinical behavior and biology of recurrent malignant salivary gland tumors are myriad with slow-growing indolent disease at the one end of spectrum and aggressive symptomatic illness with metastases to bone, lung, and liver at the other end. Several different agents and combination chemotherapy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Cancer Research, Statistics, and Treatment |
| Subjects: | |
| Online Access: | http://www.crstonline.com/article.asp?issn=2590-3233;year=2018;volume=1;issue=1;spage=10;epage=18;aulast=Pandey |
| _version_ | 1818129495692935168 |
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| author | Avinash Pandey Manish Kumar Heena Shahi Aishwarya Kumari Shivkant Singh |
| author_facet | Avinash Pandey Manish Kumar Heena Shahi Aishwarya Kumari Shivkant Singh |
| author_sort | Avinash Pandey |
| collection | DOAJ |
| description | The clinical behavior and biology of recurrent malignant salivary gland tumors are myriad with slow-growing indolent disease at the one end of spectrum and aggressive symptomatic illness with metastases to bone, lung, and liver at the other end. Several different agents and combination chemotherapy regimens have been explored in patients whose disease is symptomatic with response rates between 15% and 40%. Recently, molecular studies have evolved to reveal targetable biomarkers which can be further explored in the therapeutic landscape with specific targeted therapies. A subset of tumors also expresses hormone receptors and hence is amenable to conventional antihormonal agents to obtain a possibly meaningful benefit. We searched for all ongoing and completed clinical trials involving chemotherapy, targeted therapy, hormonal therapy, and immunotherapy valid for patients with recurrent metastatic salivary gland tumors. We present the current viable therapeutic options for such a cohort of patients in routine clinical practice. |
| first_indexed | 2024-12-11T07:50:03Z |
| format | Article |
| id | doaj.art-0113488422a64489b77efb90a2a36322 |
| institution | Directory Open Access Journal |
| issn | 2590-3233 2590-3225 |
| language | English |
| last_indexed | 2024-12-11T07:50:03Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Cancer Research, Statistics, and Treatment |
| spelling | doaj.art-0113488422a64489b77efb90a2a363222022-12-22T01:15:22ZengWolters Kluwer Medknow PublicationsCancer Research, Statistics, and Treatment2590-32332590-32252018-01-0111101810.4103/CRST.CRST_1_18Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trialsAvinash PandeyManish KumarHeena ShahiAishwarya KumariShivkant SinghThe clinical behavior and biology of recurrent malignant salivary gland tumors are myriad with slow-growing indolent disease at the one end of spectrum and aggressive symptomatic illness with metastases to bone, lung, and liver at the other end. Several different agents and combination chemotherapy regimens have been explored in patients whose disease is symptomatic with response rates between 15% and 40%. Recently, molecular studies have evolved to reveal targetable biomarkers which can be further explored in the therapeutic landscape with specific targeted therapies. A subset of tumors also expresses hormone receptors and hence is amenable to conventional antihormonal agents to obtain a possibly meaningful benefit. We searched for all ongoing and completed clinical trials involving chemotherapy, targeted therapy, hormonal therapy, and immunotherapy valid for patients with recurrent metastatic salivary gland tumors. We present the current viable therapeutic options for such a cohort of patients in routine clinical practice.http://www.crstonline.com/article.asp?issn=2590-3233;year=2018;volume=1;issue=1;spage=10;epage=18;aulast=Pandeychemotherapy; clinical trials; malignant salivary gland tumors |
| spellingShingle | Avinash Pandey Manish Kumar Heena Shahi Aishwarya Kumari Shivkant Singh Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trials Cancer Research, Statistics, and Treatment chemotherapy; clinical trials; malignant salivary gland tumors |
| title | Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trials |
| title_full | Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trials |
| title_fullStr | Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trials |
| title_full_unstemmed | Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trials |
| title_short | Novel therapeutic options for recurrent metastatic salivary gland tumors: Review of ongoing clinical trials |
| title_sort | novel therapeutic options for recurrent metastatic salivary gland tumors review of ongoing clinical trials |
| topic | chemotherapy; clinical trials; malignant salivary gland tumors |
| url | http://www.crstonline.com/article.asp?issn=2590-3233;year=2018;volume=1;issue=1;spage=10;epage=18;aulast=Pandey |
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