Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome Paitents
Background: Patients who experience acute coronary syndrome (ACS) are at high risk of having further events in the future. One month after the attack, the average readmission rate was estimated to be approximately 20%. As a result, patients must receive secondary preven-tion medications to avoid re...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2019-05-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/559 |
| _version_ | 1797223899697512448 |
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| author | Amina M. Jabri Hayder Ch. Assad |
| author_facet | Amina M. Jabri Hayder Ch. Assad |
| author_sort | Amina M. Jabri |
| collection | DOAJ |
| description |
Background: Patients who experience acute coronary syndrome (ACS) are at high risk of having further events in the future. One month after the attack, the average readmission rate was estimated to be approximately 20%. As a result, patients must receive secondary preven-tion medications to avoid reoccurrence
of these cardiovascular events. To get the entire benefit, patients must adhere to the prescribed regimen. However, many studies demonstrated that patients do not adhere to the prescribed medications upon the long term, and this leads to substantial deterioration of disease and consequently death, as well as significant financial burden. This study has the objective of assessing the impact of pharmacist intervention on increasing patients' adherence to ACS medications.
Method: a prospective interventional study was performed from January to October 2018. A total of 70 patients were selected randomly and were divided into those who received the usual care processes offered by pharmacists at discharge, and those who received well-structured clinical pharmacist intervention about the discharge medications and disease. Heart rate (HR), blood pressure (BP) and lipid profile were measured at baseline and after 3 months. Also, patients' level of adherence to the discharge medications was assessed after 3 months. Furthermore, 30 day hospital readmission rate was evaluated.
Results: Regarding patients' medication adherence, 63.3% of the patients in intervention group had high level of adherence compared to only 21.1% of controls. After 3 months of follow up significant reduction in mean scores of outcomes were noticed in intervention group compared to control, where HR (73.6 vs. 80), SBP (129.5 vs. 141), DBP (81.2 vs. 87.5). Also serum cholesterol, triglycerides, and LDL were reduced and HDL increased significantly in the intervention group (P <0.05), while no such changes seen in controls. Moreover, no considerable difference was observed in hospital readmission between the intervention and control group.
Conclusion: This study showed that pharmacist intervention caused notable enhancement in patient' medication adherence with subsequent improvement of heart rate, blood pressure, and lipid profile, but with no improvement in hospital readmission.
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| first_indexed | 2024-04-24T13:44:33Z |
| format | Article |
| id | doaj.art-0113e422e8f641288d5769d430f448ce |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:44:33Z |
| publishDate | 2019-05-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-0113e422e8f641288d5769d430f448ce2024-04-04T06:57:56ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2019-05-0119210.32947/ajps.v19i2.559Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome PaitentsAmina M. Jabri0Hayder Ch. Assad1Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, University of Kufa, Najaf Governorate, IraqDepartment of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, University of Kufa, Najaf Governorate, Iraq Background: Patients who experience acute coronary syndrome (ACS) are at high risk of having further events in the future. One month after the attack, the average readmission rate was estimated to be approximately 20%. As a result, patients must receive secondary preven-tion medications to avoid reoccurrence of these cardiovascular events. To get the entire benefit, patients must adhere to the prescribed regimen. However, many studies demonstrated that patients do not adhere to the prescribed medications upon the long term, and this leads to substantial deterioration of disease and consequently death, as well as significant financial burden. This study has the objective of assessing the impact of pharmacist intervention on increasing patients' adherence to ACS medications. Method: a prospective interventional study was performed from January to October 2018. A total of 70 patients were selected randomly and were divided into those who received the usual care processes offered by pharmacists at discharge, and those who received well-structured clinical pharmacist intervention about the discharge medications and disease. Heart rate (HR), blood pressure (BP) and lipid profile were measured at baseline and after 3 months. Also, patients' level of adherence to the discharge medications was assessed after 3 months. Furthermore, 30 day hospital readmission rate was evaluated. Results: Regarding patients' medication adherence, 63.3% of the patients in intervention group had high level of adherence compared to only 21.1% of controls. After 3 months of follow up significant reduction in mean scores of outcomes were noticed in intervention group compared to control, where HR (73.6 vs. 80), SBP (129.5 vs. 141), DBP (81.2 vs. 87.5). Also serum cholesterol, triglycerides, and LDL were reduced and HDL increased significantly in the intervention group (P <0.05), while no such changes seen in controls. Moreover, no considerable difference was observed in hospital readmission between the intervention and control group. Conclusion: This study showed that pharmacist intervention caused notable enhancement in patient' medication adherence with subsequent improvement of heart rate, blood pressure, and lipid profile, but with no improvement in hospital readmission. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/559Adherence, Outcomes, Pharmacist, Intervention, ACS. |
| spellingShingle | Amina M. Jabri Hayder Ch. Assad Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome Paitents Al-Mustansiriyah Journal of Pharmaceutical Sciences Adherence, Outcomes, Pharmacist, Intervention, ACS. |
| title | Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome Paitents |
| title_full | Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome Paitents |
| title_fullStr | Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome Paitents |
| title_full_unstemmed | Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome Paitents |
| title_short | Pharmacist Role in Enhancement of Medication Adherence and Clinical Outcomes in Acute Coronary Syndrome Paitents |
| title_sort | pharmacist role in enhancement of medication adherence and clinical outcomes in acute coronary syndrome paitents |
| topic | Adherence, Outcomes, Pharmacist, Intervention, ACS. |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/559 |
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