Case Report: Clinical and Serological Hallmarks of Cytokine Release Syndrome in a Canine B Cell Lymphoma Patient Treated With Autologous CAR-T Cells

Case Report: Clinical and Serological Hallmarks of Cytokine Release Syndrome in a Canine B Cell Lymphoma Patient Treated With Autologous CAR-T Cells

BackgroundChimeric antigen receptor-T (CAR-T) cells have transformed the treatment of human B cell malignancies. With the advent of CAR-T therapy, specific and in some cases severe toxicities have been documented with cytokine release syndrome (CRS) being the most frequently reported. As dogs develo...

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Bibliographic Details
Main Authors: Matthew J. Atherton, Antonia Rotolo, Kumudhini P. Haran, Nicola J. Mason
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Veterinary Science
Subjects:
CAR-T cells
cytokine release syndrome (CRS)
canine B cell lymphoma
comparative oncology
spontaneous tumor model
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2022.824982/full

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