Modeling of Mesoscale Variability in Biofilm Shear Behavior.
Formation of bacterial colonies as biofilm on the surface/interface of various objects has the potential to impact not only human health and disease but also energy and environmental considerations. Biofilms can be regarded as soft materials, and comprehension of their shear response to external for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5091762?pdf=render |
| _version_ | 1818241812143276032 |
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| author | Pallab Barai Aloke Kumar Partha P Mukherjee |
| author_facet | Pallab Barai Aloke Kumar Partha P Mukherjee |
| author_sort | Pallab Barai |
| collection | DOAJ |
| description | Formation of bacterial colonies as biofilm on the surface/interface of various objects has the potential to impact not only human health and disease but also energy and environmental considerations. Biofilms can be regarded as soft materials, and comprehension of their shear response to external forces is a key element to the fundamental understanding. A mesoscale model has been presented in this article based on digitization of a biofilm microstructure. Its response under externally applied shear load is analyzed. Strain stiffening type behavior is readily observed under high strain loads due to the unfolding of chains within soft polymeric substrate. Sustained shear loading of the biofilm network results in strain localization along the diagonal direction. Rupture of the soft polymeric matrix can potentially reduce the intercellular interaction between the bacterial cells. Evolution of stiffness within the biofilm network under shear reveals two regimes: a) initial increase in stiffness due to strain stiffening of polymer matrix, and b) eventual reduction in stiffness because of tear in polymeric substrate. |
| first_indexed | 2024-12-12T13:35:17Z |
| format | Article |
| id | doaj.art-0118454e821043ed8e68c2ec6d11dac6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T13:35:17Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0118454e821043ed8e68c2ec6d11dac62022-12-22T00:22:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016559310.1371/journal.pone.0165593Modeling of Mesoscale Variability in Biofilm Shear Behavior.Pallab BaraiAloke KumarPartha P MukherjeeFormation of bacterial colonies as biofilm on the surface/interface of various objects has the potential to impact not only human health and disease but also energy and environmental considerations. Biofilms can be regarded as soft materials, and comprehension of their shear response to external forces is a key element to the fundamental understanding. A mesoscale model has been presented in this article based on digitization of a biofilm microstructure. Its response under externally applied shear load is analyzed. Strain stiffening type behavior is readily observed under high strain loads due to the unfolding of chains within soft polymeric substrate. Sustained shear loading of the biofilm network results in strain localization along the diagonal direction. Rupture of the soft polymeric matrix can potentially reduce the intercellular interaction between the bacterial cells. Evolution of stiffness within the biofilm network under shear reveals two regimes: a) initial increase in stiffness due to strain stiffening of polymer matrix, and b) eventual reduction in stiffness because of tear in polymeric substrate.http://europepmc.org/articles/PMC5091762?pdf=render |
| spellingShingle | Pallab Barai Aloke Kumar Partha P Mukherjee Modeling of Mesoscale Variability in Biofilm Shear Behavior. PLoS ONE |
| title | Modeling of Mesoscale Variability in Biofilm Shear Behavior. |
| title_full | Modeling of Mesoscale Variability in Biofilm Shear Behavior. |
| title_fullStr | Modeling of Mesoscale Variability in Biofilm Shear Behavior. |
| title_full_unstemmed | Modeling of Mesoscale Variability in Biofilm Shear Behavior. |
| title_short | Modeling of Mesoscale Variability in Biofilm Shear Behavior. |
| title_sort | modeling of mesoscale variability in biofilm shear behavior |
| url | http://europepmc.org/articles/PMC5091762?pdf=render |
| work_keys_str_mv | AT pallabbarai modelingofmesoscalevariabilityinbiofilmshearbehavior AT alokekumar modelingofmesoscalevariabilityinbiofilmshearbehavior AT parthapmukherjee modelingofmesoscalevariabilityinbiofilmshearbehavior |