Synthetic and DFT Modeling Studies on Suzuki–Miyaura Reactions of 4,5-Dibromo-2-methylpyridazin-3(2<i>H</i>)-one with Ferrocene Boronates, Accompanied by Hydrodebromination and a Novel Bridge-Forming Annulation In Vitro Cytotoxic Activity of the Ferrocenyl–Pyridazinone Products

Synthetic and DFT Modeling Studies on Suzuki–Miyaura Reactions of 4,5-Dibromo-2-methylpyridazin-3(2<i>H</i>)-one with Ferrocene Boronates, Accompanied by Hydrodebromination and a Novel Bridge-Forming Annulation In Vitro Cytotoxic Activity of the Ferrocenyl–Pyridazinone Products

This paper presented the efficiency of different Pd-based catalytic systems in a series of SM reactions of 4,5-dibromo-2-methylpyridazin-3(2<i>H</i>)-one with ferroceneboronic acid, ferrocene-1,1′-diboronoc acid, and its <i>bis</i>-pinacol ester. In addition to the disubstitu...

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Bibliographic Details
Main Authors: Nour-Eddine El Alaoui, Mohammed Boulhaoua, Dániel Hutai, Rita Oláh-Szabó, Szilvia Bősze, Ferenc Hudecz, Antal Csámpai
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Catalysts
Subjects:
Suzuki–Miyaura coupling
ferrocene
ferrocenophane
hydrodehalogenation
DFT-supported reaction mechanism
transmetalation
Online Access:https://www.mdpi.com/2073-4344/12/6/578

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