Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy
OBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2006-01-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000100006 |
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| author | Antunes Alberto A. Nesrallah Luciano J. Dall'Oglio Marcos F. Ferreira Yuri A. Passerotti Carlo C. Leite Katia R. Ortiz Valdemar Srougi Miguel |
| author_facet | Antunes Alberto A. Nesrallah Luciano J. Dall'Oglio Marcos F. Ferreira Yuri A. Passerotti Carlo C. Leite Katia R. Ortiz Valdemar Srougi Miguel |
| author_sort | Antunes Alberto A. |
| collection | DOAJ |
| description | OBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of 113 patients submitted to radical cystectomy and bilateral iliac lymphadenectomy between 1993 and 2005 were reviewed. The risk factors analyzed were age, sex, pathological stage, tumor grade, presence of carcinoma in situ and the presence of lymph nodes involvement. RESULTS: After a mean follow-up of 31.7 ? 28.5 months, 46 patients (40.7%) presented recurrence and 24 patients (21.2%) died due to cancer. Only pathological stage and the lymph nodes involvement became independent variables for recurrence and survival. Patients with T4 stage presented 9.6 times the risk of recurrence of the disease when compared with stage T0 patients (p = 0.010) and the patients with lymph node involvement presented 2.5 times the risk of recurrence (p = 0.047) and 3.1 times the risk of death (p = 0.022) when compared to patients without lymph nodes involvement. CONCLUSIONS: Pathological stage and the involvement of lymph nodes represented more important prognostic variables, and in the presence of advanced stage tumors (T3/T4) and involvement of lymph nodes, the institution of adjuvant treatment should be considered. |
| first_indexed | 2024-12-10T20:35:59Z |
| format | Article |
| id | doaj.art-0119eeea810a48d88824a1740967ffbb |
| institution | Directory Open Access Journal |
| issn | 1677-5538 |
| language | English |
| last_indexed | 2024-12-10T20:35:59Z |
| publishDate | 2006-01-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-0119eeea810a48d88824a1740967ffbb2022-12-22T01:34:32ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55382006-01-013213542Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomyAntunes Alberto A.Nesrallah Luciano J.Dall'Oglio Marcos F.Ferreira Yuri A.Passerotti Carlo C.Leite Katia R.Ortiz ValdemarSrougi MiguelOBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of 113 patients submitted to radical cystectomy and bilateral iliac lymphadenectomy between 1993 and 2005 were reviewed. The risk factors analyzed were age, sex, pathological stage, tumor grade, presence of carcinoma in situ and the presence of lymph nodes involvement. RESULTS: After a mean follow-up of 31.7 ? 28.5 months, 46 patients (40.7%) presented recurrence and 24 patients (21.2%) died due to cancer. Only pathological stage and the lymph nodes involvement became independent variables for recurrence and survival. Patients with T4 stage presented 9.6 times the risk of recurrence of the disease when compared with stage T0 patients (p = 0.010) and the patients with lymph node involvement presented 2.5 times the risk of recurrence (p = 0.047) and 3.1 times the risk of death (p = 0.022) when compared to patients without lymph nodes involvement. CONCLUSIONS: Pathological stage and the involvement of lymph nodes represented more important prognostic variables, and in the presence of advanced stage tumors (T3/T4) and involvement of lymph nodes, the institution of adjuvant treatment should be considered.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000100006bladder neoplasmstransitional cellcystectomyprognosis |
| spellingShingle | Antunes Alberto A. Nesrallah Luciano J. Dall'Oglio Marcos F. Ferreira Yuri A. Passerotti Carlo C. Leite Katia R. Ortiz Valdemar Srougi Miguel Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy International Brazilian Journal of Urology bladder neoplasms transitional cell cystectomy prognosis |
| title | Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
| title_full | Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
| title_fullStr | Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
| title_full_unstemmed | Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
| title_short | Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
| title_sort | analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy |
| topic | bladder neoplasms transitional cell cystectomy prognosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000100006 |
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