In vitro evaluation of novel mefenamic acid derivatives as potential α-glucosidase and urease inhibitors: Design, synthesis, in silico and cytotoxic studies

In vitro evaluation of novel mefenamic acid derivatives as potential α-glucosidase and urease inhibitors: Design, synthesis, in silico and cytotoxic studies

This study aim to synthesize new 1,3,4-oxadiazole derivatives incorporating mefenamic acid as promising α-glucosidase and urease inhibitors, potentially leading to the treatment of postprandial hyperglycemia as well as H. pylori related disorders. In this regards, we have designed a series of Mefena...

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Bibliographic Details
Main Authors: Saima Daud, Obaid-ur-Rahman Abid, Wajid Rehman, Maryam Niaz, Asma Sardar, Liaqat Rasheed, Basit Niaz, Basit Ali Shah, Hadil Faris Alotaibi, Ahmad J. Obaidullah, Mohammed M. Alanazi
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Journal of Saudi Chemical Society
Subjects:
Mefenamic acid
Schiff bases
Enzyme inhibition
Cytotoxicity and molecular docking studies
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610323000844

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http://www.sciencedirect.com/science/article/pii/S1319610323000844

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