Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study
<p>Abstract</p> <p>Background</p> <p>Candidate gene and genome-wide association studies have both reproducibly identified several common Single Nucleotide Polymorphisms (SNPs) that confer type 2 diabetes (T2D) risk in European populations. Our aim was to evaluate the co...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-04-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/10/33 |
| _version_ | 1818903817099411456 |
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| author | Almawi Wassim Y Kacem Maha Chaieb Molka Dechaume Aurélie Vaillant Emmanuel Cauchi Stéphane Mtiraoui Nabil Ezzidi Intissar Froguel Philippe Mahjoub Touhami Vaxillaire Martine |
| author_facet | Almawi Wassim Y Kacem Maha Chaieb Molka Dechaume Aurélie Vaillant Emmanuel Cauchi Stéphane Mtiraoui Nabil Ezzidi Intissar Froguel Philippe Mahjoub Touhami Vaxillaire Martine |
| author_sort | Almawi Wassim Y |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Candidate gene and genome-wide association studies have both reproducibly identified several common Single Nucleotide Polymorphisms (SNPs) that confer type 2 diabetes (T2D) risk in European populations. Our aim was to evaluate the contribution to T2D of five of these established T2D-associated loci in the Arabic population from Tunisia.</p> <p>Methods</p> <p>A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in <it>KCNJ11/Kir6.2</it>, K121Q in <it>ENPP1</it>, the -30G/A variant in the pancreatic β-cell specific promoter of Glucokinase, rs7903146 in <it>TCF7L2 </it>encoding transcription factor 7-like2, and rs7923837 in <it>HHEX </it>encoding the homeobox, hematopoietically expressed transcription factor.</p> <p>Results</p> <p><it>TCF7L2</it>-rs7903146 T allele increased susceptibility to T2D (OR = 1.25 [1.06–1.47], <it>P </it>= 0.006) in our study population. This risk was 56% higher among subjects carrying the TT genotype in comparison to those carrying the CC genotype (OR = 1.56 [1.13–2.16], <it>P </it>= 0.002). No allelic or genotypic association with T2D was detected for the other studied polymorphisms.</p> <p>Conclusion</p> <p>In the Tunisian population, <it>TCF7L2</it>-rs7903146 T allele confers an increased risk of developing T2D as previously reported in the European population and many other ethnic groups. In contrast, none of the other tested SNPs that influence T2D risk in the European population was associated with T2D in the Tunisian Arabic population. An insufficient power to detect minor allelic contributions or genetic heterogeneity of T2D between different ethnic groups can explain these findings.</p> |
| first_indexed | 2024-12-19T20:57:34Z |
| format | Article |
| id | doaj.art-011bd70ae23442b3bce669d3f0ffc105 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-19T20:57:34Z |
| publishDate | 2009-04-01 |
| publisher | BMC |
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| series | BMC Medical Genetics |
| spelling | doaj.art-011bd70ae23442b3bce669d3f0ffc1052022-12-21T20:05:55ZengBMCBMC Medical Genetics1471-23502009-04-011013310.1186/1471-2350-10-33Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control studyAlmawi Wassim YKacem MahaChaieb MolkaDechaume AurélieVaillant EmmanuelCauchi StéphaneMtiraoui NabilEzzidi IntissarFroguel PhilippeMahjoub TouhamiVaxillaire Martine<p>Abstract</p> <p>Background</p> <p>Candidate gene and genome-wide association studies have both reproducibly identified several common Single Nucleotide Polymorphisms (SNPs) that confer type 2 diabetes (T2D) risk in European populations. Our aim was to evaluate the contribution to T2D of five of these established T2D-associated loci in the Arabic population from Tunisia.</p> <p>Methods</p> <p>A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in <it>KCNJ11/Kir6.2</it>, K121Q in <it>ENPP1</it>, the -30G/A variant in the pancreatic β-cell specific promoter of Glucokinase, rs7903146 in <it>TCF7L2 </it>encoding transcription factor 7-like2, and rs7923837 in <it>HHEX </it>encoding the homeobox, hematopoietically expressed transcription factor.</p> <p>Results</p> <p><it>TCF7L2</it>-rs7903146 T allele increased susceptibility to T2D (OR = 1.25 [1.06–1.47], <it>P </it>= 0.006) in our study population. This risk was 56% higher among subjects carrying the TT genotype in comparison to those carrying the CC genotype (OR = 1.56 [1.13–2.16], <it>P </it>= 0.002). No allelic or genotypic association with T2D was detected for the other studied polymorphisms.</p> <p>Conclusion</p> <p>In the Tunisian population, <it>TCF7L2</it>-rs7903146 T allele confers an increased risk of developing T2D as previously reported in the European population and many other ethnic groups. In contrast, none of the other tested SNPs that influence T2D risk in the European population was associated with T2D in the Tunisian Arabic population. An insufficient power to detect minor allelic contributions or genetic heterogeneity of T2D between different ethnic groups can explain these findings.</p>http://www.biomedcentral.com/1471-2350/10/33 |
| spellingShingle | Almawi Wassim Y Kacem Maha Chaieb Molka Dechaume Aurélie Vaillant Emmanuel Cauchi Stéphane Mtiraoui Nabil Ezzidi Intissar Froguel Philippe Mahjoub Touhami Vaxillaire Martine Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study BMC Medical Genetics |
| title | Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study |
| title_full | Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study |
| title_fullStr | Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study |
| title_full_unstemmed | Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study |
| title_short | Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study |
| title_sort | contribution of type 2 diabetes associated loci in the arabic population from tunisia a case control study |
| url | http://www.biomedcentral.com/1471-2350/10/33 |
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