The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study.
The increasing burden of pneumonia in adults is an emerging health issue in the era of global population aging. This study was conducted to elucidate the burden of community-onset pneumonia (COP) and its etiologic fractions in Japan, the world's most aged society.A multicenter prospective surve...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4378946?pdf=render |
| _version_ | 1818337471597903872 |
|---|---|
| author | Konosuke Morimoto Motoi Suzuki Tomoko Ishifuji Makito Yaegashi Norichika Asoh Naohisa Hamashige Masahiko Abe Masahiro Aoshima Koya Ariyoshi Adult Pneumonia Study Group-Japan (APSG-J) |
| author_facet | Konosuke Morimoto Motoi Suzuki Tomoko Ishifuji Makito Yaegashi Norichika Asoh Naohisa Hamashige Masahiko Abe Masahiro Aoshima Koya Ariyoshi Adult Pneumonia Study Group-Japan (APSG-J) |
| author_sort | Konosuke Morimoto |
| collection | DOAJ |
| description | The increasing burden of pneumonia in adults is an emerging health issue in the era of global population aging. This study was conducted to elucidate the burden of community-onset pneumonia (COP) and its etiologic fractions in Japan, the world's most aged society.A multicenter prospective surveillance for COP was conducted from September 2011 to January 2013 in Japan. All pneumonia patients aged ≥ 15 years, including those with community-acquired pneumonia (CAP) and health care-associated pneumonia (HCAP), were enrolled at four community hospitals on four major islands. The COP burden was estimated based on the surveillance data and national statistics.A total of 1,772 COP episodes out of 932,080 hospital visits were enrolled during the surveillance. The estimated overall incidence rates of adult COP, hospitalization, and in-hospital death were 16.9 (95% confidence interval, 13.6 to 20.9), 5.3 (4.5 to 6.2), and 0.7 (0.6 to 0.8) per 1,000 person-years (PY), respectively. The incidence rates sharply increased with age; the incidence in people aged ≥ 85 years was 10-fold higher than that in people aged 15-64 years. The estimated annual number of adult COP cases in the entire Japanese population was 1,880,000, and 69.4% were aged ≥ 65 years. Aspiration-associated pneumonia (630,000) was the leading etiologic category, followed by Streptococcus pneumoniae-associated pneumonia (530,000), Haemophilus influenzae-associated pneumonia (420,000), and respiratory virus-associated pneumonia (420,000), including influenza-associated pneumonia (30,000).A substantial portion of the COP burden occurs among elderly members of the Japanese adult population. In addition to the introduction of effective vaccines for S. pneumoniae and influenza, multidimensional approaches are needed to reduce the pneumonia burden in an aging society. |
| first_indexed | 2024-12-13T14:55:45Z |
| format | Article |
| id | doaj.art-01230e87454f4aaaafb5ca444d983dc7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T14:55:45Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-01230e87454f4aaaafb5ca444d983dc72022-12-21T23:41:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012224710.1371/journal.pone.0122247The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study.Konosuke MorimotoMotoi SuzukiTomoko IshifujiMakito YaegashiNorichika AsohNaohisa HamashigeMasahiko AbeMasahiro AoshimaKoya AriyoshiAdult Pneumonia Study Group-Japan (APSG-J)The increasing burden of pneumonia in adults is an emerging health issue in the era of global population aging. This study was conducted to elucidate the burden of community-onset pneumonia (COP) and its etiologic fractions in Japan, the world's most aged society.A multicenter prospective surveillance for COP was conducted from September 2011 to January 2013 in Japan. All pneumonia patients aged ≥ 15 years, including those with community-acquired pneumonia (CAP) and health care-associated pneumonia (HCAP), were enrolled at four community hospitals on four major islands. The COP burden was estimated based on the surveillance data and national statistics.A total of 1,772 COP episodes out of 932,080 hospital visits were enrolled during the surveillance. The estimated overall incidence rates of adult COP, hospitalization, and in-hospital death were 16.9 (95% confidence interval, 13.6 to 20.9), 5.3 (4.5 to 6.2), and 0.7 (0.6 to 0.8) per 1,000 person-years (PY), respectively. The incidence rates sharply increased with age; the incidence in people aged ≥ 85 years was 10-fold higher than that in people aged 15-64 years. The estimated annual number of adult COP cases in the entire Japanese population was 1,880,000, and 69.4% were aged ≥ 65 years. Aspiration-associated pneumonia (630,000) was the leading etiologic category, followed by Streptococcus pneumoniae-associated pneumonia (530,000), Haemophilus influenzae-associated pneumonia (420,000), and respiratory virus-associated pneumonia (420,000), including influenza-associated pneumonia (30,000).A substantial portion of the COP burden occurs among elderly members of the Japanese adult population. In addition to the introduction of effective vaccines for S. pneumoniae and influenza, multidimensional approaches are needed to reduce the pneumonia burden in an aging society.http://europepmc.org/articles/PMC4378946?pdf=render |
| spellingShingle | Konosuke Morimoto Motoi Suzuki Tomoko Ishifuji Makito Yaegashi Norichika Asoh Naohisa Hamashige Masahiko Abe Masahiro Aoshima Koya Ariyoshi Adult Pneumonia Study Group-Japan (APSG-J) The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. PLoS ONE |
| title | The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. |
| title_full | The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. |
| title_fullStr | The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. |
| title_full_unstemmed | The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. |
| title_short | The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. |
| title_sort | burden and etiology of community onset pneumonia in the aging japanese population a multicenter prospective study |
| url | http://europepmc.org/articles/PMC4378946?pdf=render |
| work_keys_str_mv | AT konosukemorimoto theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT motoisuzuki theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT tomokoishifuji theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT makitoyaegashi theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT norichikaasoh theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT naohisahamashige theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT masahikoabe theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT masahiroaoshima theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT koyaariyoshi theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT adultpneumoniastudygroupjapanapsgj theburdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT konosukemorimoto burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT motoisuzuki burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT tomokoishifuji burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT makitoyaegashi burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT norichikaasoh burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT naohisahamashige burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT masahikoabe burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT masahiroaoshima burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT koyaariyoshi burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy AT adultpneumoniastudygroupjapanapsgj burdenandetiologyofcommunityonsetpneumoniaintheagingjapanesepopulationamulticenterprospectivestudy |