Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome
IntroductionThis study investigated the potential modifying effects of the serum brain-derived neurotrophic factor (sBDNF) level on the association between BDNF methylation status and long-term cardiovascular outcomes in acute coronary syndrome (ACS) patients.MethodsFrom 2006 to 2012, hospitalized A...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1084834/full |
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| author | Wonsuk Choi Hee-Ju Kang Ju-Wan Kim Hee Kyung Kim Ho-Cheol Kang Sung-Wan Kim Jung-Chul Kim Youngkeun Ahn Myung Ho Jeong Jae-Min Kim |
| author_facet | Wonsuk Choi Hee-Ju Kang Ju-Wan Kim Hee Kyung Kim Ho-Cheol Kang Sung-Wan Kim Jung-Chul Kim Youngkeun Ahn Myung Ho Jeong Jae-Min Kim |
| author_sort | Wonsuk Choi |
| collection | DOAJ |
| description | IntroductionThis study investigated the potential modifying effects of the serum brain-derived neurotrophic factor (sBDNF) level on the association between BDNF methylation status and long-term cardiovascular outcomes in acute coronary syndrome (ACS) patients.MethodsFrom 2006 to 2012, hospitalized ACS patients were consecutively recruited. The sBDNF level and BDNF methylation status were assessed at baseline in 969 patients who were followed up for major adverse cardiac events (MACEs) over 5–12 years, until 2017 or death. Cox proportional hazards models were utilized to compare the time to first composite or individual MACEs between individuals with lower and those with higher average BDNF methylation levels in the low and high sBDNF groups, respectively. The modifying effects of the sBDNF and average BDNF methylation levels on first composite and individual MACEs were analyzed using Cox proportional hazards models after adjusting for potential covariates.ResultsIn the low sBDNF group, a higher average BDNF methylation level was linked to an increase in composite MACEs independent of confounding variables, but not in the high sBDNF group [HR (95 percent CI) = 1.04 (0.76–1.44)]. The interaction effect between the sBDNF and average BDNF methylation levels on composite MACEs was significant after adjusting for covariates (P = 0.008).ConclusionCombining the BDNF methylation status and sBDNF levels may help identify ACS patients who are likely to have unfavorable clinical outcomes. |
| first_indexed | 2024-04-10T22:18:10Z |
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| id | doaj.art-0124349ed27542b4995672f411337a01 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-10T22:18:10Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-0124349ed27542b4995672f411337a012023-01-18T05:45:13ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.10848341084834Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndromeWonsuk Choi0Hee-Ju Kang1Ju-Wan Kim2Hee Kyung Kim3Ho-Cheol Kang4Sung-Wan Kim5Jung-Chul Kim6Youngkeun Ahn7Myung Ho Jeong8Jae-Min Kim9Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Republic of KoreaDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of KoreaDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of KoreaDepartment of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Republic of KoreaDepartment of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Republic of KoreaDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of KoreaDepartment of Surgery, Chonnam National University Medical School and Hospital, Gwangju, Republic of KoreaDepartment of Cardiology, Chonnam National University Medical School, Gwangju, Republic of KoreaDepartment of Cardiology, Chonnam National University Medical School, Gwangju, Republic of KoreaDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of KoreaIntroductionThis study investigated the potential modifying effects of the serum brain-derived neurotrophic factor (sBDNF) level on the association between BDNF methylation status and long-term cardiovascular outcomes in acute coronary syndrome (ACS) patients.MethodsFrom 2006 to 2012, hospitalized ACS patients were consecutively recruited. The sBDNF level and BDNF methylation status were assessed at baseline in 969 patients who were followed up for major adverse cardiac events (MACEs) over 5–12 years, until 2017 or death. Cox proportional hazards models were utilized to compare the time to first composite or individual MACEs between individuals with lower and those with higher average BDNF methylation levels in the low and high sBDNF groups, respectively. The modifying effects of the sBDNF and average BDNF methylation levels on first composite and individual MACEs were analyzed using Cox proportional hazards models after adjusting for potential covariates.ResultsIn the low sBDNF group, a higher average BDNF methylation level was linked to an increase in composite MACEs independent of confounding variables, but not in the high sBDNF group [HR (95 percent CI) = 1.04 (0.76–1.44)]. The interaction effect between the sBDNF and average BDNF methylation levels on composite MACEs was significant after adjusting for covariates (P = 0.008).ConclusionCombining the BDNF methylation status and sBDNF levels may help identify ACS patients who are likely to have unfavorable clinical outcomes.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1084834/fullbrain derived neurotrophic factor (BDNF)BDNF methylationacute coronary syndrome (ACS)outcomebiomarker |
| spellingShingle | Wonsuk Choi Hee-Ju Kang Ju-Wan Kim Hee Kyung Kim Ho-Cheol Kang Sung-Wan Kim Jung-Chul Kim Youngkeun Ahn Myung Ho Jeong Jae-Min Kim Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome Frontiers in Cardiovascular Medicine brain derived neurotrophic factor (BDNF) BDNF methylation acute coronary syndrome (ACS) outcome biomarker |
| title | Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome |
| title_full | Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome |
| title_fullStr | Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome |
| title_full_unstemmed | Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome |
| title_short | Modifying effect of the serum level of brain-derived neurotrophic factor (BDNF) on the association between BDNF methylation and long-term cardiovascular outcomes in patients with acute coronary syndrome |
| title_sort | modifying effect of the serum level of brain derived neurotrophic factor bdnf on the association between bdnf methylation and long term cardiovascular outcomes in patients with acute coronary syndrome |
| topic | brain derived neurotrophic factor (BDNF) BDNF methylation acute coronary syndrome (ACS) outcome biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1084834/full |
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