Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock
Abstract The clinical impact of different polymer technologies in newer-generation drug-eluting stents (DESs) for patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains poorly understood. We investigated the efficacy and safety of durable polymer DESs (DP-DESs)...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-56925-2 |
| _version_ | 1797259258345029632 |
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| author | Woo Jin Jang Ik Hyun Park Ju Hyeon Oh Ki Hong Choi Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Hyeon-Cheol Gwon Chul-Min Ahn Cheol Woong Yu Hyun-Joong Kim Jang-Whan Bae Sung Uk Kwon Hyun Jong Lee Wang Soo Lee Jin-Ok Jeong Sang-Don Park Jeong Hoon Yang |
| author_facet | Woo Jin Jang Ik Hyun Park Ju Hyeon Oh Ki Hong Choi Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Hyeon-Cheol Gwon Chul-Min Ahn Cheol Woong Yu Hyun-Joong Kim Jang-Whan Bae Sung Uk Kwon Hyun Jong Lee Wang Soo Lee Jin-Ok Jeong Sang-Don Park Jeong Hoon Yang |
| author_sort | Woo Jin Jang |
| collection | DOAJ |
| description | Abstract The clinical impact of different polymer technologies in newer-generation drug-eluting stents (DESs) for patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains poorly understood. We investigated the efficacy and safety of durable polymer DESs (DP-DESs) compared with biodegradable polymer DESs (BP-DESs). A total of 620 patients who underwent percutaneous coronary intervention with newer-generation DESs for AMI complicated by CS was divided into two groups based on polymer technology: the DP-DES group (n = 374) and the BP-DES group (n = 246). The primary outcome was target vessel failure (TVF) during a 12-month follow-up, defined as a composite of cardiac death, myocardial infarction, or target vessel revascularization. Both the DP-DES and BP-DES groups exhibited low stent thrombosis rates (1.3% vs. 1.6%, p = 0.660). The risk of TVF did not significantly differ between the two groups (34.2% vs. 28.5%, hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.69–1.29, p = 0.721). This finding remained consistent after adjustment with inverse probability of treatment weighting (28.1% vs. 25.1%, HR 0.98, 95% CI 0.77–1.27, p = 0.899). In AMI patients complicated by CS, the risk of a composite of cardiac death, myocardial infarction, or target vessel revascularization was not significantly different between those treated with DP-DESs and those treated with BP-DESs. Trial registration: RESCUE registry, https://clinicaltrials.gov/ct2/show/NCT02985008 , NCT02985008. |
| first_indexed | 2024-04-24T23:06:34Z |
| format | Article |
| id | doaj.art-012466cd95a740b1b38a9385eb702c2a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:06:34Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-012466cd95a740b1b38a9385eb702c2a2024-03-17T12:24:32ZengNature PortfolioScientific Reports2045-23222024-03-0114111010.1038/s41598-024-56925-2Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shockWoo Jin Jang0Ik Hyun Park1Ju Hyeon Oh2Ki Hong Choi3Young Bin Song4Joo-Yong Hahn5Seung-Hyuk Choi6Hyeon-Cheol Gwon7Chul-Min Ahn8Cheol Woong Yu9Hyun-Joong Kim10Jang-Whan Bae11Sung Uk Kwon12Hyun Jong Lee13Wang Soo Lee14Jin-Ok Jeong15Sang-Don Park16Jeong Hoon Yang17Division of Cardiology, Chung-Ang University HospitalDepartment of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of MedicineDepartment of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of MedicineDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of MedicineDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDivision of Cardiology, Konkuk University Medical CenterDivision of Cardiology, Chungbuk National University College of MedicineDivision of Cardiology, Ilsan Paik Hospital, University of Inje College of MedicineDivision of Cardiology, Sejong General HospitalDivision of Cardiology, Chung-Ang University HospitalDivision of Cardiology, Chungnam National University HospitalDivision of Cardiology, Inha University HospitalDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract The clinical impact of different polymer technologies in newer-generation drug-eluting stents (DESs) for patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains poorly understood. We investigated the efficacy and safety of durable polymer DESs (DP-DESs) compared with biodegradable polymer DESs (BP-DESs). A total of 620 patients who underwent percutaneous coronary intervention with newer-generation DESs for AMI complicated by CS was divided into two groups based on polymer technology: the DP-DES group (n = 374) and the BP-DES group (n = 246). The primary outcome was target vessel failure (TVF) during a 12-month follow-up, defined as a composite of cardiac death, myocardial infarction, or target vessel revascularization. Both the DP-DES and BP-DES groups exhibited low stent thrombosis rates (1.3% vs. 1.6%, p = 0.660). The risk of TVF did not significantly differ between the two groups (34.2% vs. 28.5%, hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.69–1.29, p = 0.721). This finding remained consistent after adjustment with inverse probability of treatment weighting (28.1% vs. 25.1%, HR 0.98, 95% CI 0.77–1.27, p = 0.899). In AMI patients complicated by CS, the risk of a composite of cardiac death, myocardial infarction, or target vessel revascularization was not significantly different between those treated with DP-DESs and those treated with BP-DESs. Trial registration: RESCUE registry, https://clinicaltrials.gov/ct2/show/NCT02985008 , NCT02985008.https://doi.org/10.1038/s41598-024-56925-2PolymersDrug-eluting stentCardiogenic shockMyocardial infarction |
| spellingShingle | Woo Jin Jang Ik Hyun Park Ju Hyeon Oh Ki Hong Choi Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Hyeon-Cheol Gwon Chul-Min Ahn Cheol Woong Yu Hyun-Joong Kim Jang-Whan Bae Sung Uk Kwon Hyun Jong Lee Wang Soo Lee Jin-Ok Jeong Sang-Don Park Jeong Hoon Yang Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock Scientific Reports Polymers Drug-eluting stent Cardiogenic shock Myocardial infarction |
| title | Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_full | Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_fullStr | Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_full_unstemmed | Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_short | Efficacy and safety of durable versus biodegradable polymer drug-eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_sort | efficacy and safety of durable versus biodegradable polymer drug eluting stents in patients with acute myocardial infarction complicated by cardiogenic shock |
| topic | Polymers Drug-eluting stent Cardiogenic shock Myocardial infarction |
| url | https://doi.org/10.1038/s41598-024-56925-2 |
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