ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division
Membrane contact sites between organelles have specialized functions that are only beginning to be understood. Here, the authors show that ORP1L mediates lysosome recruitment and PI(4)P signaling at endoplasmic reticulum-lysosome-mitochondria three-way contact sites involved in mitochondrial divisio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25621-4 |
| _version_ | 1818570600653783040 |
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| author | Maxime Boutry Peter K. Kim |
| author_facet | Maxime Boutry Peter K. Kim |
| author_sort | Maxime Boutry |
| collection | DOAJ |
| description | Membrane contact sites between organelles have specialized functions that are only beginning to be understood. Here, the authors show that ORP1L mediates lysosome recruitment and PI(4)P signaling at endoplasmic reticulum-lysosome-mitochondria three-way contact sites involved in mitochondrial division. |
| first_indexed | 2024-12-14T13:44:06Z |
| format | Article |
| id | doaj.art-01261280289d4046a8337f23a607b7b4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:44:06Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-01261280289d4046a8337f23a607b7b42022-12-21T22:59:22ZengNature PortfolioNature Communications2041-17232021-09-0112111810.1038/s41467-021-25621-4ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial divisionMaxime Boutry0Peter K. Kim1Cell Biology Program, Hospital for Sick Children, Peter Gilgan Centre for Research and LearningCell Biology Program, Hospital for Sick Children, Peter Gilgan Centre for Research and LearningMembrane contact sites between organelles have specialized functions that are only beginning to be understood. Here, the authors show that ORP1L mediates lysosome recruitment and PI(4)P signaling at endoplasmic reticulum-lysosome-mitochondria three-way contact sites involved in mitochondrial division.https://doi.org/10.1038/s41467-021-25621-4 |
| spellingShingle | Maxime Boutry Peter K. Kim ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division Nature Communications |
| title | ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division |
| title_full | ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division |
| title_fullStr | ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division |
| title_full_unstemmed | ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division |
| title_short | ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division |
| title_sort | orp1l mediated pi 4 p signaling at er lysosome mitochondrion three way contact contributes to mitochondrial division |
| url | https://doi.org/10.1038/s41467-021-25621-4 |
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