Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort.
OBJECTIVE: In a large population-based cohort in Denmark to examine if maternal use of antibiotics during pregnancy, as a marker of infection, increases the risk of febrile seizures in childhood in a large population-based cohort in Denmark. METHODS: All live-born singletons born in Denmark between...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3627381?pdf=render |
| _version_ | 1811226217934749696 |
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| author | Jessica E Miller Lars Henning Pedersen Mogens Vestergaard Jørn Olsen |
| author_facet | Jessica E Miller Lars Henning Pedersen Mogens Vestergaard Jørn Olsen |
| author_sort | Jessica E Miller |
| collection | DOAJ |
| description | OBJECTIVE: In a large population-based cohort in Denmark to examine if maternal use of antibiotics during pregnancy, as a marker of infection, increases the risk of febrile seizures in childhood in a large population-based cohort in Denmark. METHODS: All live-born singletons born in Denmark between January 1, 1996 and September 25, 2004 and who were alive on the 90(th) day of life were identified from the Danish National Birth Registry. Diagnoses of febrile seizures were obtained from the Danish National Hospital Register and maternal use of antibiotics was obtained from the National Register of Medicinal Product Statistics. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated by Cox proportional hazard regression models. RESULTS: We followed 551,518 singletons for up to 5 years and identified a total of 21,779 children with a diagnosis of febrile seizures. Slightly increased hazard ratios were observed among most exposure groups when compared to the unexposed group, ex. HR 1.08 95% CI: 1.05-1.11 for use of any systemic antibiotic during pregnancy. CONCLUSION: We found weak associations between the use of pharmacologically different antibiotics during pregnancy and febrile seizures in early childhood which may indicate that some infections, or causes or effects of infections, during pregnancy could affect the fetal brain and induce susceptibility to febrile seizures. |
| first_indexed | 2024-04-12T09:21:03Z |
| format | Article |
| id | doaj.art-01280d2025164164a91d737727a3986e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T09:21:03Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-01280d2025164164a91d737727a3986e2022-12-22T03:38:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6114810.1371/journal.pone.0061148Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort.Jessica E MillerLars Henning PedersenMogens VestergaardJørn OlsenOBJECTIVE: In a large population-based cohort in Denmark to examine if maternal use of antibiotics during pregnancy, as a marker of infection, increases the risk of febrile seizures in childhood in a large population-based cohort in Denmark. METHODS: All live-born singletons born in Denmark between January 1, 1996 and September 25, 2004 and who were alive on the 90(th) day of life were identified from the Danish National Birth Registry. Diagnoses of febrile seizures were obtained from the Danish National Hospital Register and maternal use of antibiotics was obtained from the National Register of Medicinal Product Statistics. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated by Cox proportional hazard regression models. RESULTS: We followed 551,518 singletons for up to 5 years and identified a total of 21,779 children with a diagnosis of febrile seizures. Slightly increased hazard ratios were observed among most exposure groups when compared to the unexposed group, ex. HR 1.08 95% CI: 1.05-1.11 for use of any systemic antibiotic during pregnancy. CONCLUSION: We found weak associations between the use of pharmacologically different antibiotics during pregnancy and febrile seizures in early childhood which may indicate that some infections, or causes or effects of infections, during pregnancy could affect the fetal brain and induce susceptibility to febrile seizures.http://europepmc.org/articles/PMC3627381?pdf=render |
| spellingShingle | Jessica E Miller Lars Henning Pedersen Mogens Vestergaard Jørn Olsen Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort. PLoS ONE |
| title | Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort. |
| title_full | Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort. |
| title_fullStr | Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort. |
| title_full_unstemmed | Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort. |
| title_short | Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort. |
| title_sort | maternal use of antibiotics and the risk of childhood febrile seizures a danish population based cohort |
| url | http://europepmc.org/articles/PMC3627381?pdf=render |
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