Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein
<p>The JC polyoma viral coat protein VP1 was analyzed for amino acid sequences homologies to the IDSP sequence which mediates binding of VLA-4 (integrin alpha 4) to vascular cell adhesion molecule 1. Although the full sequence was not found, a DSP sequence was located near the critical arginin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-07-01
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| Series: | Neurology International |
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| Online Access: | http://www.pagepress.org/journals/index.php/ni/article/view/4854 |
| _version_ | 1797717101624950784 |
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| author | Michael Andrew Meyer |
| author_facet | Michael Andrew Meyer |
| author_sort | Michael Andrew Meyer |
| collection | DOAJ |
| description | <p>The JC polyoma viral coat protein VP1 was analyzed for amino acid sequences homologies to the IDSP sequence which mediates binding of VLA-4 (integrin alpha 4) to vascular cell adhesion molecule 1. Although the full sequence was not found, a DSP sequence was located near the critical arginine residue linked to infectivity of the virus and binding to sialic acid containing molecules such as integrins (3). For the JC polyoma virus, a DSP sequence was found at residues 70, 71 and 72 with homology also noted for the mouse polyoma virus and SV40 virus. Three dimensional modeling of the VP1 molecule suggests that the DSP loop has an accessible site for interaction from the external side of the assembled viral capsid pentamer.</p> |
| first_indexed | 2024-03-12T08:31:26Z |
| format | Article |
| id | doaj.art-0129330b012048eb9b82f564fd3e22aa |
| institution | Directory Open Access Journal |
| issn | 2035-8385 2035-8377 |
| language | English |
| last_indexed | 2024-03-12T08:31:26Z |
| publishDate | 2013-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-0129330b012048eb9b82f564fd3e22aa2023-09-02T17:31:46ZengMDPI AGNeurology International2035-83852035-83772013-07-0153e14e1410.4081/ni.2013.e142569Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat proteinMichael Andrew Meyer0Department of Neurology, Tennova Health Care, Knoxville, TN<p>The JC polyoma viral coat protein VP1 was analyzed for amino acid sequences homologies to the IDSP sequence which mediates binding of VLA-4 (integrin alpha 4) to vascular cell adhesion molecule 1. Although the full sequence was not found, a DSP sequence was located near the critical arginine residue linked to infectivity of the virus and binding to sialic acid containing molecules such as integrins (3). For the JC polyoma virus, a DSP sequence was found at residues 70, 71 and 72 with homology also noted for the mouse polyoma virus and SV40 virus. Three dimensional modeling of the VP1 molecule suggests that the DSP loop has an accessible site for interaction from the external side of the assembled viral capsid pentamer.</p>http://www.pagepress.org/journals/index.php/ni/article/view/4854JC, polyoma, virus, VP1, capsid, alpha 4 integrin, PML |
| spellingShingle | Michael Andrew Meyer Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein Neurology International JC, polyoma, virus, VP1, capsid, alpha 4 integrin, PML |
| title | Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein |
| title_full | Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein |
| title_fullStr | Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein |
| title_full_unstemmed | Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein |
| title_short | Amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4: homologous DSP sequence found for JC polyoma VP1 coat protein |
| title_sort | amino acid sequences mediating vascular cell adhesion molecule 1 binding to integrin alpha 4 homologous dsp sequence found for jc polyoma vp1 coat protein |
| topic | JC, polyoma, virus, VP1, capsid, alpha 4 integrin, PML |
| url | http://www.pagepress.org/journals/index.php/ni/article/view/4854 |
| work_keys_str_mv | AT michaelandrewmeyer aminoacidsequencesmediatingvascularcelladhesionmolecule1bindingtointegrinalpha4homologousdspsequencefoundforjcpolyomavp1coatprotein |