Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography
ObjectiveOptic chiasma compression and associated visual impairment induced by a non-functioning pituitary adenoma (NFPA) is commonly assessed by the optic disk and retina but is inadequate to understand the entire visual pathway impairment. We aim to evaluate the use of optical coherence tomography...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1057781/full |
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| author | Yanhua Pang Zhi Tan Xinxin Chen Zhihui Liao Xin Yang Qin Zhong Baqi Huang Qianshuo Zhong Jingxiang Zhong Jingxiang Zhong Wei Mo |
| author_facet | Yanhua Pang Zhi Tan Xinxin Chen Zhihui Liao Xin Yang Qin Zhong Baqi Huang Qianshuo Zhong Jingxiang Zhong Jingxiang Zhong Wei Mo |
| author_sort | Yanhua Pang |
| collection | DOAJ |
| description | ObjectiveOptic chiasma compression and associated visual impairment induced by a non-functioning pituitary adenoma (NFPA) is commonly assessed by the optic disk and retina but is inadequate to understand the entire visual pathway impairment. We aim to evaluate the use of optical coherence tomography (OCT) coupled with diffusion tensor imaging (DTI) for the preoperative evaluation of visual pathway impairment.MethodsFifty-three patients with NFPA (categorized into mild and heavy compression subgroups) were subjected to OCT to calculate the thickness of the circumpapillary retinal nerve fiber layer (CP-RNFL), macular ganglion cell complex (GCC), macular ganglion cell layer (GCL), and macular inner plexus layer (IPL), as well as to DTI to calculate the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values.ResultsCompared to mild compression, heavy compression caused decreased FA value, increased ADC value of several segments of the visual pathway, thin temporal CP-RNFL, and quadrant macular GCC, IPL, and GCL. Average CP-RNFL thickness, inferior-macular inner-ring IPL and GCC thicknesses, inferior CP-RNFL thickness, and superior CP-RNFL thickness were the best indicators of the impairment of the optic nerve, optic chiasma, optic tract, and optic radiation, respectively.ConclusionDTI and OCT parameters can effectively evaluate visual pathway impairment and are beneficial for the objective preoperative evaluation of visual pathway impairment in patients with NFPA. |
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| spelling | doaj.art-01295abc78ab4acd96f5d1806a4b55de2023-02-09T07:23:19ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-02-011710.3389/fnins.2023.10577811057781Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomographyYanhua Pang0Zhi Tan1Xinxin Chen2Zhihui Liao3Xin Yang4Qin Zhong5Baqi Huang6Qianshuo Zhong7Jingxiang Zhong8Jingxiang Zhong9Wei Mo10Department of Ophthalmology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaTeaching and Research Center of Medical Communication Science, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Ophthalmology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Ophthalmology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Neurosurgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Neurosurgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Ophthalmology, The Sixth Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Neurosurgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaObjectiveOptic chiasma compression and associated visual impairment induced by a non-functioning pituitary adenoma (NFPA) is commonly assessed by the optic disk and retina but is inadequate to understand the entire visual pathway impairment. We aim to evaluate the use of optical coherence tomography (OCT) coupled with diffusion tensor imaging (DTI) for the preoperative evaluation of visual pathway impairment.MethodsFifty-three patients with NFPA (categorized into mild and heavy compression subgroups) were subjected to OCT to calculate the thickness of the circumpapillary retinal nerve fiber layer (CP-RNFL), macular ganglion cell complex (GCC), macular ganglion cell layer (GCL), and macular inner plexus layer (IPL), as well as to DTI to calculate the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values.ResultsCompared to mild compression, heavy compression caused decreased FA value, increased ADC value of several segments of the visual pathway, thin temporal CP-RNFL, and quadrant macular GCC, IPL, and GCL. Average CP-RNFL thickness, inferior-macular inner-ring IPL and GCC thicknesses, inferior CP-RNFL thickness, and superior CP-RNFL thickness were the best indicators of the impairment of the optic nerve, optic chiasma, optic tract, and optic radiation, respectively.ConclusionDTI and OCT parameters can effectively evaluate visual pathway impairment and are beneficial for the objective preoperative evaluation of visual pathway impairment in patients with NFPA.https://www.frontiersin.org/articles/10.3389/fnins.2023.1057781/fullnon-functioning pituitary adenomadiffusion tensor imaging (DTI)visual pathway injuryoptical coherence tomography (OCT)circumpapillary retinal nerve fiber layer (CP-RNFL) |
| spellingShingle | Yanhua Pang Zhi Tan Xinxin Chen Zhihui Liao Xin Yang Qin Zhong Baqi Huang Qianshuo Zhong Jingxiang Zhong Jingxiang Zhong Wei Mo Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography Frontiers in Neuroscience non-functioning pituitary adenoma diffusion tensor imaging (DTI) visual pathway injury optical coherence tomography (OCT) circumpapillary retinal nerve fiber layer (CP-RNFL) |
| title | Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography |
| title_full | Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography |
| title_fullStr | Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography |
| title_full_unstemmed | Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography |
| title_short | Evaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography |
| title_sort | evaluation of preoperative visual pathway impairment in patients with non functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography |
| topic | non-functioning pituitary adenoma diffusion tensor imaging (DTI) visual pathway injury optical coherence tomography (OCT) circumpapillary retinal nerve fiber layer (CP-RNFL) |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1057781/full |
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