Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance

<p><span style="font-family: Calibri;">Malignant transformation of fibrous dysplasia is rare, occurring in less than 1% of cases with a mean lag period of 13.5 years. We report a case of Osteogenic Sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occur...

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Main Authors: S Gon, B Majumdar, A Bhattacharyya, RN Bhattacharya
Format: Article
Language:English
Published: Association of Clinical Pathologists of Nepal 2012-09-01
Series:Journal of Pathology of Nepal
Subjects:
Online Access:http://www.nepjol.info/index.php/JPN/article/view/6891
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author S Gon
B Majumdar
A Bhattacharyya
RN Bhattacharya
author_facet S Gon
B Majumdar
A Bhattacharyya
RN Bhattacharya
author_sort S Gon
collection DOAJ
description <p><span style="font-family: Calibri;">Malignant transformation of fibrous dysplasia is rare, occurring in less than 1% of cases with a mean lag period of 13.5 years. We report a case of Osteogenic Sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation. To the best of our knowledge and extensive search of literature, malignant transformation of Fibrous Dysplasia in such a short period of time, and without history of radiation exposure has never been reported from India.</span></p><p><span style="font-family: Calibri;">Journal of Pathology of Nepal (2012) Vol. 2, 335-337</span></p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v2i4.6891">http://dx.doi.org/10.3126/jpn.v2i4.6891</a>
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spelling doaj.art-012aab0806d44e8584c2f5668d6a13e12022-12-21T18:57:32ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082012-09-012433533710.3126/jpn.v2i4.68915493Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occuranceS Gon0B Majumdar1A Bhattacharyya2RN Bhattacharya3Department of Pathology, RG Kar Medical College & Hospital,KolkataDepartment of Pathology, RG Kar Medical College & Hospital,KolkataDepartment of Pathology, RG Kar Medical College & Hospital,KolkataDepartment of Plastic & Reconstructive Surgery, RG Kar Medical College & Hospital, Kolkata<p><span style="font-family: Calibri;">Malignant transformation of fibrous dysplasia is rare, occurring in less than 1% of cases with a mean lag period of 13.5 years. We report a case of Osteogenic Sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation. To the best of our knowledge and extensive search of literature, malignant transformation of Fibrous Dysplasia in such a short period of time, and without history of radiation exposure has never been reported from India.</span></p><p><span style="font-family: Calibri;">Journal of Pathology of Nepal (2012) Vol. 2, 335-337</span></p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v2i4.6891">http://dx.doi.org/10.3126/jpn.v2i4.6891</a>http://www.nepjol.info/index.php/JPN/article/view/6891Fibrous dysplasiaMalignant transformationOsteogenic sarcoma
spellingShingle S Gon
B Majumdar
A Bhattacharyya
RN Bhattacharya
Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance
Journal of Pathology of Nepal
Fibrous dysplasia
Malignant transformation
Osteogenic sarcoma
title Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance
title_full Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance
title_fullStr Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance
title_full_unstemmed Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance
title_short Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance
title_sort fibrous dysplasia rapid malignant transformation into osteogenic sarcoma a rare occurance
topic Fibrous dysplasia
Malignant transformation
Osteogenic sarcoma
url http://www.nepjol.info/index.php/JPN/article/view/6891
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AT bmajumdar fibrousdysplasiarapidmalignanttransformationintoosteogenicsarcomaarareoccurance
AT abhattacharyya fibrousdysplasiarapidmalignanttransformationintoosteogenicsarcomaarareoccurance
AT rnbhattacharya fibrousdysplasiarapidmalignanttransformationintoosteogenicsarcomaarareoccurance