Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke
BackgroundThe inflammatory response plays an important role in ischemic stroke, and the incidence of stroke in young adults has increased rapidly in recent years. The C-reactive protein-to-albumin ratio (CAR) is a new index that reflects the overall inflammatory status of patients with major disease...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.989769/full |
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| author | Yang Du Yang Du Jia Zhang Jia Zhang Ning Li Ning Li Jiahuan Guo Jiahuan Guo Xinmin Liu Xinmin Liu Liheng Bian Liheng Bian Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao Yanfang Liu Yanfang Liu |
| author_facet | Yang Du Yang Du Jia Zhang Jia Zhang Ning Li Ning Li Jiahuan Guo Jiahuan Guo Xinmin Liu Xinmin Liu Liheng Bian Liheng Bian Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao Yanfang Liu Yanfang Liu |
| author_sort | Yang Du |
| collection | DOAJ |
| description | BackgroundThe inflammatory response plays an important role in ischemic stroke, and the incidence of stroke in young adults has increased rapidly in recent years. The C-reactive protein-to-albumin ratio (CAR) is a new index that reflects the overall inflammatory status of patients with major diseases; however, no studies have reported the relationship between CAR and young stroke.MethodsThe participants' baseline characteristics and laboratory examination results, including CAR, were obtained at admission. The modified Rankin Scale (mRS) scores at the 30-day and 90-day follow-ups were obtained from all patients. All the participants included in the study were classified into four groups according to CAR quartiles (Q1–Q4). Logistic regression was used to analyze the relationship between different CAR levels and adverse outcomes (mRS 3–6 and mRS 2–6). We also plotted receiver operating characteristic curves of CAR for adverse clinical outcomes and calculated the area under the curve and cutoff values.ResultsA total of 630 patients with young stroke were enrolled in the study. In the multivariate logistic regression model, at the 30-day follow-up, the Q3 and Q4 (significantly increased CAR) groups showed an elevated risk of mRS score of 2–6 (odds ratio [OR]: 2.94; 95% confidence interval [CI]: 1.40–6.16, p < 0.01; OR: 4.01; 95% CI: 1.88–8.91, p < 0.01). At the 90-day follow-up, the Q3 and Q4 groups still showed an elevated risk of an mRS score of 2–6 (Q3, OR: 2.76; 95% CI: 1.30–5.86, p < 0.01; Q4, OR: 2.63; 95% CI: 1.22–5.65, p < 0.01).ConclusionA significantly increased CAR was independently associated with an increased risk of adverse outcomes in young patients with stroke. |
| first_indexed | 2024-04-11T08:05:27Z |
| format | Article |
| id | doaj.art-012ac957be2843449c1e6c9c43d32bf0 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T08:05:27Z |
| publishDate | 2022-11-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-012ac957be2843449c1e6c9c43d32bf02022-12-22T04:35:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.989769989769Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young strokeYang Du0Yang Du1Jia Zhang2Jia Zhang3Ning Li4Ning Li5Jiahuan Guo6Jiahuan Guo7Xinmin Liu8Xinmin Liu9Liheng Bian10Liheng Bian11Xingquan Zhao12Xingquan Zhao13Xingquan Zhao14Xingquan Zhao15Yanfang Liu16Yanfang Liu17Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, ChinaBackgroundThe inflammatory response plays an important role in ischemic stroke, and the incidence of stroke in young adults has increased rapidly in recent years. The C-reactive protein-to-albumin ratio (CAR) is a new index that reflects the overall inflammatory status of patients with major diseases; however, no studies have reported the relationship between CAR and young stroke.MethodsThe participants' baseline characteristics and laboratory examination results, including CAR, were obtained at admission. The modified Rankin Scale (mRS) scores at the 30-day and 90-day follow-ups were obtained from all patients. All the participants included in the study were classified into four groups according to CAR quartiles (Q1–Q4). Logistic regression was used to analyze the relationship between different CAR levels and adverse outcomes (mRS 3–6 and mRS 2–6). We also plotted receiver operating characteristic curves of CAR for adverse clinical outcomes and calculated the area under the curve and cutoff values.ResultsA total of 630 patients with young stroke were enrolled in the study. In the multivariate logistic regression model, at the 30-day follow-up, the Q3 and Q4 (significantly increased CAR) groups showed an elevated risk of mRS score of 2–6 (odds ratio [OR]: 2.94; 95% confidence interval [CI]: 1.40–6.16, p < 0.01; OR: 4.01; 95% CI: 1.88–8.91, p < 0.01). At the 90-day follow-up, the Q3 and Q4 groups still showed an elevated risk of an mRS score of 2–6 (Q3, OR: 2.76; 95% CI: 1.30–5.86, p < 0.01; Q4, OR: 2.63; 95% CI: 1.22–5.65, p < 0.01).ConclusionA significantly increased CAR was independently associated with an increased risk of adverse outcomes in young patients with stroke.https://www.frontiersin.org/articles/10.3389/fneur.2022.989769/fullC-reactive protein to albumin ratioprognosisstroke in young adultsyoung strokeinflammation |
| spellingShingle | Yang Du Yang Du Jia Zhang Jia Zhang Ning Li Ning Li Jiahuan Guo Jiahuan Guo Xinmin Liu Xinmin Liu Liheng Bian Liheng Bian Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao Yanfang Liu Yanfang Liu Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke Frontiers in Neurology C-reactive protein to albumin ratio prognosis stroke in young adults young stroke inflammation |
| title | Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke |
| title_full | Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke |
| title_fullStr | Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke |
| title_full_unstemmed | Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke |
| title_short | Association between the C-reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke |
| title_sort | association between the c reactive protein to albumin ratio and adverse clinical prognosis in patients with young stroke |
| topic | C-reactive protein to albumin ratio prognosis stroke in young adults young stroke inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.989769/full |
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