Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling
The use of FeCl3 resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO2, i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2011-08-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.7.122 |
| _version_ | 1818954909348790272 |
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| author | Aiichiro Nagaki Yuki Uesugi Yutaka Tomida Jun-ichi Yoshida |
| author_facet | Aiichiro Nagaki Yuki Uesugi Yutaka Tomida Jun-ichi Yoshida |
| author_sort | Aiichiro Nagaki |
| collection | DOAJ |
| description | The use of FeCl3 resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO2, in under a minute. |
| first_indexed | 2024-12-20T10:29:39Z |
| format | Article |
| id | doaj.art-012b95c689914580a26aa962ce1e9059 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-20T10:29:39Z |
| publishDate | 2011-08-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-012b95c689914580a26aa962ce1e90592022-12-21T19:43:45ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972011-08-01711064106910.3762/bjoc.7.1221860-5397-7-122Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocouplingAiichiro Nagaki0Yuki Uesugi1Yutaka Tomida2Jun-ichi Yoshida3Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigakukatsura, Nishikyo-ku, Kyoto, 615-8510, JapanDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigakukatsura, Nishikyo-ku, Kyoto, 615-8510, JapanDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigakukatsura, Nishikyo-ku, Kyoto, 615-8510, JapanDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigakukatsura, Nishikyo-ku, Kyoto, 615-8510, JapanThe use of FeCl3 resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO2, in under a minute.https://doi.org/10.3762/bjoc.7.122homocouplingiron saltsmicroreactororganolithiums |
| spellingShingle | Aiichiro Nagaki Yuki Uesugi Yutaka Tomida Jun-ichi Yoshida Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling Beilstein Journal of Organic Chemistry homocoupling iron salts microreactor organolithiums |
| title | Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling |
| title_full | Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling |
| title_fullStr | Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling |
| title_full_unstemmed | Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling |
| title_short | Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling |
| title_sort | homocoupling of aryl halides in flow space integration of lithiation and fecl3 promoted homocoupling |
| topic | homocoupling iron salts microreactor organolithiums |
| url | https://doi.org/10.3762/bjoc.7.122 |
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