Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in Taiwan
Background/purpose: This study aimed to analyze the long-term outcomes of hypofractionated whole-breast irradiation (WBI) (HF-WBI) compared with those of conventionally fractionated WBI (CF-WBI) for early breast cancer treated with breast-conservation surgery (BCS) and adjuvant WBI in Taiwan. Method...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664622000353 |
| _version_ | 1811295994555400192 |
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| author | Wei-Kai Chuang Skye Hung-Chun Cheng Chen-Fang Hung Tzu-Ting Huang Chung-Wen Jen Jia-Hua Yen Yu-Chen Tsai |
| author_facet | Wei-Kai Chuang Skye Hung-Chun Cheng Chen-Fang Hung Tzu-Ting Huang Chung-Wen Jen Jia-Hua Yen Yu-Chen Tsai |
| author_sort | Wei-Kai Chuang |
| collection | DOAJ |
| description | Background/purpose: This study aimed to analyze the long-term outcomes of hypofractionated whole-breast irradiation (WBI) (HF-WBI) compared with those of conventionally fractionated WBI (CF-WBI) for early breast cancer treated with breast-conservation surgery (BCS) and adjuvant WBI in Taiwan. Methods: This study included patients treated at our institution between 2012 and 2016. All patients with early breast cancer received BCS (pT1–2, pN0, M0) and adjuvant WBI through one of two treatment schemes. Propensity score matching analysis was conducted to create comparable cohorts. The major result is ipsilateral breast tumor recurrence (IBTR) rates and overall survival rates. Results: A total of 869 patients with early-stage breast cancer received adjuvant HF-WBI or CF-WBI were included. After matching, 718 patients were separated into two groups of the same number. With a median follow-up of 66 months, seven cases of IBTR were noted (three for CF, four for HF). There were no significant differences between the HF-WBI and CF-WBI groups in 5-year IBTR rates (0.9% vs 0.6%, P = 0.3887, 95% CI [0.25–7.79]) and 5-year overall survival rates (98.1% vs 98.9%, P = 0.4702, 95% CI [0.32–3.49]). In our institution, the use of HF-WBI increased significantly from 5% before 2012 (Q3) to 92% in 2016 (Q4). There was no significant difference in grade 1–2 toxicity between the two treatment groups. Fewer cases of grade 3 skin toxicity noted in the HF-WBI group (zero vs four events). Conclusion: HF-WBI had similar IBTR, OS and toxicity to CF-WBI. |
| first_indexed | 2024-04-13T05:42:43Z |
| format | Article |
| id | doaj.art-012bb8e9c47543ce93249f352ce0a6d0 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-13T05:42:43Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-012bb8e9c47543ce93249f352ce0a6d02022-12-22T03:00:03ZengElsevierJournal of the Formosan Medical Association0929-66462022-08-01121815881595Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in TaiwanWei-Kai Chuang0Skye Hung-Chun Cheng1Chen-Fang Hung2Tzu-Ting Huang3Chung-Wen Jen4Jia-Hua Yen5Yu-Chen Tsai6Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan; Department of Radiation Oncology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Corresponding author. Department of Radiation Oncology, Shuang-Ho Hospital, Taipei Medical University, No.291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan. Fax: +(02)22481121.Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanDepartment of Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanDepartment of Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanDepartment of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanDepartment of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanDepartment of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanBackground/purpose: This study aimed to analyze the long-term outcomes of hypofractionated whole-breast irradiation (WBI) (HF-WBI) compared with those of conventionally fractionated WBI (CF-WBI) for early breast cancer treated with breast-conservation surgery (BCS) and adjuvant WBI in Taiwan. Methods: This study included patients treated at our institution between 2012 and 2016. All patients with early breast cancer received BCS (pT1–2, pN0, M0) and adjuvant WBI through one of two treatment schemes. Propensity score matching analysis was conducted to create comparable cohorts. The major result is ipsilateral breast tumor recurrence (IBTR) rates and overall survival rates. Results: A total of 869 patients with early-stage breast cancer received adjuvant HF-WBI or CF-WBI were included. After matching, 718 patients were separated into two groups of the same number. With a median follow-up of 66 months, seven cases of IBTR were noted (three for CF, four for HF). There were no significant differences between the HF-WBI and CF-WBI groups in 5-year IBTR rates (0.9% vs 0.6%, P = 0.3887, 95% CI [0.25–7.79]) and 5-year overall survival rates (98.1% vs 98.9%, P = 0.4702, 95% CI [0.32–3.49]). In our institution, the use of HF-WBI increased significantly from 5% before 2012 (Q3) to 92% in 2016 (Q4). There was no significant difference in grade 1–2 toxicity between the two treatment groups. Fewer cases of grade 3 skin toxicity noted in the HF-WBI group (zero vs four events). Conclusion: HF-WBI had similar IBTR, OS and toxicity to CF-WBI.http://www.sciencedirect.com/science/article/pii/S0929664622000353Adjuvant radiotherapyHypofrationation radiotherapyEarly breast cancerBreast cancer adjuvant radiotherapyHypofractionated breast radiotherapy |
| spellingShingle | Wei-Kai Chuang Skye Hung-Chun Cheng Chen-Fang Hung Tzu-Ting Huang Chung-Wen Jen Jia-Hua Yen Yu-Chen Tsai Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in Taiwan Journal of the Formosan Medical Association Adjuvant radiotherapy Hypofrationation radiotherapy Early breast cancer Breast cancer adjuvant radiotherapy Hypofractionated breast radiotherapy |
| title | Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in Taiwan |
| title_full | Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in Taiwan |
| title_fullStr | Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in Taiwan |
| title_full_unstemmed | Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in Taiwan |
| title_short | Comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer: A single-center real-world study in Taiwan |
| title_sort | comparison between the use of hypofractionated and conventionally fractionated radiotherapy in early breast cancer a single center real world study in taiwan |
| topic | Adjuvant radiotherapy Hypofrationation radiotherapy Early breast cancer Breast cancer adjuvant radiotherapy Hypofractionated breast radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S0929664622000353 |
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