Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study
ObjectiveWe aimed to explore the predictive value of stimulated thyroglobulin (sTg) and pre-ablation antithyroglobulin (pa-TgAb) products for the effect of radioiodine therapy (RAIT) on TgAb-positive differentiated thyroid cancer (DTC) patients.MethodsIn this study, we enrolled 265 patients with TgA...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1222470/full |
| _version_ | 1797676857845350400 |
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| author | Na Han Chenghui Lu Jiao Li Congcong Wang Zilong Zhao Zilong Zhao Yingying Zhang Xinfeng Liu Zengmei Si Guoqiang Wang Zenghua Wang Fengqi Li Xufu Wang |
| author_facet | Na Han Chenghui Lu Jiao Li Congcong Wang Zilong Zhao Zilong Zhao Yingying Zhang Xinfeng Liu Zengmei Si Guoqiang Wang Zenghua Wang Fengqi Li Xufu Wang |
| author_sort | Na Han |
| collection | DOAJ |
| description | ObjectiveWe aimed to explore the predictive value of stimulated thyroglobulin (sTg) and pre-ablation antithyroglobulin (pa-TgAb) products for the effect of radioiodine therapy (RAIT) on TgAb-positive differentiated thyroid cancer (DTC) patients.MethodsIn this study, we enrolled 265 patients with TgAb-positive DTC who underwent RAIT after total thyroidectomy (TT). Based on the last follow-up result, the patients were divided into two groups: the excellent response (ER) group and the non-excellent response (NER) group. We analyzed the factors related to the effect of RAIT.ResultsThe ER group consisted of 197 patients. The NER group consisted of 68 patients. For the univariate analysis, we found that the maximal tumor diameter, whether with extrathyroidal extension (ETE), bilateral or unilateral primary lesion, multifocality, preoperative TgAb (preop-TgAb), pa-TgAb, sTg × pa-TgAb, initial RAIT dose, N stage, and surgical extent (modified radical neck dissection or not), showed significant differences between the ER group and NER group (all p-values <0.05). The receiver operating characteristic (ROC) curves showed that the cutoff value was 724.25 IU/ml, 424.00 IU/ml, and 59.73 for preop-TgAb, pa-TgAb, and sTg × pa-TgAb, respectively. The multivariate logistic regression analysis results indicated that pa-TgAb, sTg × pa-TgAb, initial RAIT dose, and N stage were independent risk factors for NER (all p-values <0.05). For the Kaplan–Meier analysis of disease-free survival (DFS), the median DFS of the patients with sTg × pa-TgAb < 59.73 and initial RAIT dose ≤ 100 mCi was significantly longer than that of the patients with sTg × pa-TgAb ≥ 59.73 (50.27 months vs. 48.59 months, p = 0.041) and initial RAIT dose >100 mCi (50.50 months vs. 38.00 months, p = 0.030).ConclusionWe found the sTg and pa-TgAb conducts is a good predictor of the efficacy of RAIT in TgAb-positive DTC patients. It can play a very positive and important role in optimizing treatment, improving prognosis, and reducing the burden of patients. |
| first_indexed | 2024-03-11T22:36:31Z |
| format | Article |
| id | doaj.art-012c862044a0452b8d98eb99364b13d3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T22:36:31Z |
| publishDate | 2023-09-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-012c862044a0452b8d98eb99364b13d32023-09-22T13:02:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-09-011410.3389/fendo.2023.12224701222470Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective studyNa Han0Chenghui Lu1Jiao Li2Congcong Wang3Zilong Zhao4Zilong Zhao5Yingying Zhang6Xinfeng Liu7Zengmei Si8Guoqiang Wang9Zenghua Wang10Fengqi Li11Xufu Wang12Department of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, Ordos Central Hospital, Ordos, Inner Mongolia, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaObjectiveWe aimed to explore the predictive value of stimulated thyroglobulin (sTg) and pre-ablation antithyroglobulin (pa-TgAb) products for the effect of radioiodine therapy (RAIT) on TgAb-positive differentiated thyroid cancer (DTC) patients.MethodsIn this study, we enrolled 265 patients with TgAb-positive DTC who underwent RAIT after total thyroidectomy (TT). Based on the last follow-up result, the patients were divided into two groups: the excellent response (ER) group and the non-excellent response (NER) group. We analyzed the factors related to the effect of RAIT.ResultsThe ER group consisted of 197 patients. The NER group consisted of 68 patients. For the univariate analysis, we found that the maximal tumor diameter, whether with extrathyroidal extension (ETE), bilateral or unilateral primary lesion, multifocality, preoperative TgAb (preop-TgAb), pa-TgAb, sTg × pa-TgAb, initial RAIT dose, N stage, and surgical extent (modified radical neck dissection or not), showed significant differences between the ER group and NER group (all p-values <0.05). The receiver operating characteristic (ROC) curves showed that the cutoff value was 724.25 IU/ml, 424.00 IU/ml, and 59.73 for preop-TgAb, pa-TgAb, and sTg × pa-TgAb, respectively. The multivariate logistic regression analysis results indicated that pa-TgAb, sTg × pa-TgAb, initial RAIT dose, and N stage were independent risk factors for NER (all p-values <0.05). For the Kaplan–Meier analysis of disease-free survival (DFS), the median DFS of the patients with sTg × pa-TgAb < 59.73 and initial RAIT dose ≤ 100 mCi was significantly longer than that of the patients with sTg × pa-TgAb ≥ 59.73 (50.27 months vs. 48.59 months, p = 0.041) and initial RAIT dose >100 mCi (50.50 months vs. 38.00 months, p = 0.030).ConclusionWe found the sTg and pa-TgAb conducts is a good predictor of the efficacy of RAIT in TgAb-positive DTC patients. It can play a very positive and important role in optimizing treatment, improving prognosis, and reducing the burden of patients.https://www.frontiersin.org/articles/10.3389/fendo.2023.1222470/fulldifferentiated thyroid cancerserum antithyroglobulin antibodyradioiodine therapyresponse to therapyprognosis |
| spellingShingle | Na Han Chenghui Lu Jiao Li Congcong Wang Zilong Zhao Zilong Zhao Yingying Zhang Xinfeng Liu Zengmei Si Guoqiang Wang Zenghua Wang Fengqi Li Xufu Wang Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study Frontiers in Endocrinology differentiated thyroid cancer serum antithyroglobulin antibody radioiodine therapy response to therapy prognosis |
| title | Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study |
| title_full | Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study |
| title_fullStr | Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study |
| title_full_unstemmed | Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study |
| title_short | Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study |
| title_sort | stimulated thyroglobulin and pre ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of tgab positive differentiated thyroid cancer patients a retrospective study |
| topic | differentiated thyroid cancer serum antithyroglobulin antibody radioiodine therapy response to therapy prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1222470/full |
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