An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD
Abstract Euler‐Lagrange CFD simulations, where the biotic phase is represented by computational particles (parcels), provide information on environmental gradients inside bioreactors from the microbial perspective. Such information is highly relevant for reactor scale‐down and process optimization....
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-01-01
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| Series: | Engineering in Life Sciences |
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| Online Access: | https://doi.org/10.1002/elsc.202100159 |
| _version_ | 1797961251420110848 |
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| author | Cees Haringa |
| author_facet | Cees Haringa |
| author_sort | Cees Haringa |
| collection | DOAJ |
| description | Abstract Euler‐Lagrange CFD simulations, where the biotic phase is represented by computational particles (parcels), provide information on environmental gradients inside bioreactors from the microbial perspective. Such information is highly relevant for reactor scale‐down and process optimization. One of the major challenges is the computational intensity of CFD simulations, especially when resolution of dynamics in the flowfield is required. Lattice‐Boltzmann large‐eddy simulations (LB‐LES) form a very promising approach for simulating accurate, dynamic flowfields in stirred reactors, at strongly reduced computation times compared to finite volume approaches. In this work, the performance of LB‐LES in resolving substrate gradients in large‐scale bioreactors is explored, combined with the inclusion of a Lagrangian biotic phase to provide the microbial perspective. In addition, the hydrodynamic performance of the simulations is confirmed by verification of hydrodynamic characteristics (radial velocity, turbulent kinetic energy, energy dissipation) in the impeller discharge stream of a 29 cm diameter stirred tank. The results are compared with prior finite volume simulation results, both in terms of hydrodynamic and biokinetic observations, and time requirements. |
| first_indexed | 2024-04-11T00:56:06Z |
| format | Article |
| id | doaj.art-012d078ca3b54d9f97f98406abbf4a9f |
| institution | Directory Open Access Journal |
| issn | 1618-0240 1618-2863 |
| language | English |
| last_indexed | 2024-04-11T00:56:06Z |
| publishDate | 2023-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Engineering in Life Sciences |
| spelling | doaj.art-012d078ca3b54d9f97f98406abbf4a9f2023-01-05T02:40:22ZengWiley-VCHEngineering in Life Sciences1618-02401618-28632023-01-01231n/an/a10.1002/elsc.202100159An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFDCees Haringa0Bioprocess Engineering Biotechnology Department Delft University of Technology Delft the NetherlandsAbstract Euler‐Lagrange CFD simulations, where the biotic phase is represented by computational particles (parcels), provide information on environmental gradients inside bioreactors from the microbial perspective. Such information is highly relevant for reactor scale‐down and process optimization. One of the major challenges is the computational intensity of CFD simulations, especially when resolution of dynamics in the flowfield is required. Lattice‐Boltzmann large‐eddy simulations (LB‐LES) form a very promising approach for simulating accurate, dynamic flowfields in stirred reactors, at strongly reduced computation times compared to finite volume approaches. In this work, the performance of LB‐LES in resolving substrate gradients in large‐scale bioreactors is explored, combined with the inclusion of a Lagrangian biotic phase to provide the microbial perspective. In addition, the hydrodynamic performance of the simulations is confirmed by verification of hydrodynamic characteristics (radial velocity, turbulent kinetic energy, energy dissipation) in the impeller discharge stream of a 29 cm diameter stirred tank. The results are compared with prior finite volume simulation results, both in terms of hydrodynamic and biokinetic observations, and time requirements.https://doi.org/10.1002/elsc.202100159CFDEuler‐LagrangefermentationLattice Boltzmannlifeline analysis |
| spellingShingle | Cees Haringa An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD Engineering in Life Sciences CFD Euler‐Lagrange fermentation Lattice Boltzmann lifeline analysis |
| title | An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD |
| title_full | An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD |
| title_fullStr | An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD |
| title_full_unstemmed | An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD |
| title_short | An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD |
| title_sort | analysis of organism lifelines in an industrial bioreactor using lattice boltzmann cfd |
| topic | CFD Euler‐Lagrange fermentation Lattice Boltzmann lifeline analysis |
| url | https://doi.org/10.1002/elsc.202100159 |
| work_keys_str_mv | AT ceesharinga ananalysisoforganismlifelinesinanindustrialbioreactorusinglatticeboltzmanncfd AT ceesharinga analysisoforganismlifelinesinanindustrialbioreactorusinglatticeboltzmanncfd |