An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone
Abstract Background Finite element modelling the material behavior of bone in-silico is a powerful tool to predict the best suited surgical treatment for individual patients. Results We demonstrate the development and use of a pre-processing plug-in program with a 3D modelling image processing softw...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
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| Series: | BMC Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42490-022-00065-z |
| _version_ | 1811208778333290496 |
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| author | Gregory R. Roytman Matan Cutler Kenneth Milligan Steven M. Tommasini Daniel H. Wiznia |
| author_facet | Gregory R. Roytman Matan Cutler Kenneth Milligan Steven M. Tommasini Daniel H. Wiznia |
| author_sort | Gregory R. Roytman |
| collection | DOAJ |
| description | Abstract Background Finite element modelling the material behavior of bone in-silico is a powerful tool to predict the best suited surgical treatment for individual patients. Results We demonstrate the development and use of a pre-processing plug-in program with a 3D modelling image processing software suite (Synopsys Simpleware, ScanIP) to assist with identifying, isolating, and defining cortical and trabecular bone material properties from patient specific computed tomography scans. The workflow starts by calibrating grayscale values of each constituent element with a phantom – a standardized object with defined densities. Using an established power law equation, we convert the apparent density value per voxel to a Young’s Modulus. The resulting “calibrated” scan can be used for modeling and in-silico experimentation with Finite Element Analysis. Conclusions This process allows for the creation of realistic and personalized simulations to inform a surgeon’s decision-making. We have made this plug-in program open and accessible as a supplemental file. |
| first_indexed | 2024-04-12T04:27:25Z |
| format | Article |
| id | doaj.art-01308abea7384accb8879861719d3f5a |
| institution | Directory Open Access Journal |
| issn | 2524-4426 |
| language | English |
| last_indexed | 2024-04-12T04:27:25Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biomedical Engineering |
| spelling | doaj.art-01308abea7384accb8879861719d3f5a2022-12-22T03:48:02ZengBMCBMC Biomedical Engineering2524-44262022-09-01411610.1186/s42490-022-00065-zAn open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular boneGregory R. Roytman0Matan Cutler1Kenneth Milligan2Steven M. Tommasini3Daniel H. Wiznia4Yale Center for Medical Informatics, Yale School of MedicineIsoPlexis Proteomic SolutionOrthopedics and Rehabilitation, Yale School of MedicineOrthopedics and Rehabilitation, Yale School of MedicineOrthopedics and Rehabilitation, Yale School of MedicineAbstract Background Finite element modelling the material behavior of bone in-silico is a powerful tool to predict the best suited surgical treatment for individual patients. Results We demonstrate the development and use of a pre-processing plug-in program with a 3D modelling image processing software suite (Synopsys Simpleware, ScanIP) to assist with identifying, isolating, and defining cortical and trabecular bone material properties from patient specific computed tomography scans. The workflow starts by calibrating grayscale values of each constituent element with a phantom – a standardized object with defined densities. Using an established power law equation, we convert the apparent density value per voxel to a Young’s Modulus. The resulting “calibrated” scan can be used for modeling and in-silico experimentation with Finite Element Analysis. Conclusions This process allows for the creation of realistic and personalized simulations to inform a surgeon’s decision-making. We have made this plug-in program open and accessible as a supplemental file.https://doi.org/10.1186/s42490-022-00065-zMaterialsFinite element analysisComputed tomographyOrthopedicsSimulationIn-Silico |
| spellingShingle | Gregory R. Roytman Matan Cutler Kenneth Milligan Steven M. Tommasini Daniel H. Wiznia An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone BMC Biomedical Engineering Materials Finite element analysis Computed tomography Orthopedics Simulation In-Silico |
| title | An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone |
| title_full | An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone |
| title_fullStr | An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone |
| title_full_unstemmed | An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone |
| title_short | An open-access plug-in program for 3D modelling distinct material properties of cortical and trabecular bone |
| title_sort | open access plug in program for 3d modelling distinct material properties of cortical and trabecular bone |
| topic | Materials Finite element analysis Computed tomography Orthopedics Simulation In-Silico |
| url | https://doi.org/10.1186/s42490-022-00065-z |
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