Effect of high Intensity Interval Training on Adiponectin Leptin Ratio and C-Reactive Protein in Streptozotocin Nicotinamide Induced Diabetic Rats
Introduction: Changes in plasma adipicin and inflammatory parameters in type 2 diabetes are due to obesity and directly related to the condition of diabetes. The aim of this study was to investigate the effect of High intensity interval training (HIIT) on the ratio of adiponectin to leptin and C-rea...
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| Format: | Article |
| Language: | fas |
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Ilam University of Medical Sciences
2019-04-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
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| Online Access: | http://sjimu.medilam.ac.ir/article-1-4904-en.html |
| _version_ | 1811317045953822720 |
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| author | Mohammad Parastesh Abbas Saremi |
| author_facet | Mohammad Parastesh Abbas Saremi |
| author_sort | Mohammad Parastesh |
| collection | DOAJ |
| description | Introduction: Changes in plasma adipicin and inflammatory parameters in type 2 diabetes are due to obesity and directly related to the condition of diabetes. The aim of this study was to investigate the effect of High intensity interval training (HIIT) on the ratio of adiponectin to leptin and C-reactive protein (CRP) in type 2 diabetic rats.
Materials & Methods: In this experimental study, 42 Wistar rats with mean weight of 205±54 were randomly assigned to healthy control, diabetic control and diabetic training groups. The diabetic training group received ten weeks of HIIT training following the induction of diabetes. At the end of the experimental period, blood samples were taken to assess leptin, adiponectin and insulin resistance. Data were analyzed by one-way ANOVA and Tukey's post hoc test at a significant level of 0.05%.
Findings: The induction of diabetes by streptozotocin-nicotinamide resulted in a significant decrease in adiponectin (P =0.000) and leptin (P=0.000) and a significant increase in C-reactive protein (P=0.000) in diabetic control group compared to healthy control group Became 10 weeks of HIIT training resulted in a significant decrease in fasting blood glucose (P=0.109), C-reactive protein (P=0.024), and a significant increase in serum leptin levels (P=0.001), adiponectin (P=0.42) In the HIIT training group compared to the diabetic control group.
Discussion & Conclusions: It seems that HIIT training improves inflammation (C-reactive protein) in type 2 diabetic rats by altering serum levels of adiponectin and leptin. In the present study, 10 weeks of HIIT training led to an increase in the ratio of adiponectin to leptin and consequent reduction of C-reactive protein. |
| first_indexed | 2024-04-13T11:59:59Z |
| format | Article |
| id | doaj.art-01320ddb015342139a08305145fe1c99 |
| institution | Directory Open Access Journal |
| issn | 1563-4728 2588-3135 |
| language | fas |
| last_indexed | 2024-04-13T11:59:59Z |
| publishDate | 2019-04-01 |
| publisher | Ilam University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| spelling | doaj.art-01320ddb015342139a08305145fe1c992022-12-22T02:47:48ZfasIlam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352019-04-01271192202Effect of high Intensity Interval Training on Adiponectin Leptin Ratio and C-Reactive Protein in Streptozotocin Nicotinamide Induced Diabetic RatsMohammad Parastesh0Abbas Saremi1 Arak univercity Dept of Sport Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran Introduction: Changes in plasma adipicin and inflammatory parameters in type 2 diabetes are due to obesity and directly related to the condition of diabetes. The aim of this study was to investigate the effect of High intensity interval training (HIIT) on the ratio of adiponectin to leptin and C-reactive protein (CRP) in type 2 diabetic rats. Materials & Methods: In this experimental study, 42 Wistar rats with mean weight of 205±54 were randomly assigned to healthy control, diabetic control and diabetic training groups. The diabetic training group received ten weeks of HIIT training following the induction of diabetes. At the end of the experimental period, blood samples were taken to assess leptin, adiponectin and insulin resistance. Data were analyzed by one-way ANOVA and Tukey's post hoc test at a significant level of 0.05%. Findings: The induction of diabetes by streptozotocin-nicotinamide resulted in a significant decrease in adiponectin (P =0.000) and leptin (P=0.000) and a significant increase in C-reactive protein (P=0.000) in diabetic control group compared to healthy control group Became 10 weeks of HIIT training resulted in a significant decrease in fasting blood glucose (P=0.109), C-reactive protein (P=0.024), and a significant increase in serum leptin levels (P=0.001), adiponectin (P=0.42) In the HIIT training group compared to the diabetic control group. Discussion & Conclusions: It seems that HIIT training improves inflammation (C-reactive protein) in type 2 diabetic rats by altering serum levels of adiponectin and leptin. In the present study, 10 weeks of HIIT training led to an increase in the ratio of adiponectin to leptin and consequent reduction of C-reactive protein.http://sjimu.medilam.ac.ir/article-1-4904-en.htmltype 2 diabeticadiponectin/leptin ratioc-reactive proteinhiit training |
| spellingShingle | Mohammad Parastesh Abbas Saremi Effect of high Intensity Interval Training on Adiponectin Leptin Ratio and C-Reactive Protein in Streptozotocin Nicotinamide Induced Diabetic Rats Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām type 2 diabetic adiponectin/leptin ratio c-reactive protein hiit training |
| title | Effect of high Intensity Interval Training on Adiponectin Leptin
Ratio and C-Reactive Protein in Streptozotocin
Nicotinamide Induced Diabetic Rats |
| title_full | Effect of high Intensity Interval Training on Adiponectin Leptin
Ratio and C-Reactive Protein in Streptozotocin
Nicotinamide Induced Diabetic Rats |
| title_fullStr | Effect of high Intensity Interval Training on Adiponectin Leptin
Ratio and C-Reactive Protein in Streptozotocin
Nicotinamide Induced Diabetic Rats |
| title_full_unstemmed | Effect of high Intensity Interval Training on Adiponectin Leptin
Ratio and C-Reactive Protein in Streptozotocin
Nicotinamide Induced Diabetic Rats |
| title_short | Effect of high Intensity Interval Training on Adiponectin Leptin
Ratio and C-Reactive Protein in Streptozotocin
Nicotinamide Induced Diabetic Rats |
| title_sort | effect of high intensity interval training on adiponectin leptin ratio and c reactive protein in streptozotocin nicotinamide induced diabetic rats |
| topic | type 2 diabetic adiponectin/leptin ratio c-reactive protein hiit training |
| url | http://sjimu.medilam.ac.ir/article-1-4904-en.html |
| work_keys_str_mv | AT mohammadparastesh effectofhighintensityintervaltrainingonadiponectinleptinratioandcreactiveproteininstreptozotocinnicotinamideinduceddiabeticrats AT abbassaremi effectofhighintensityintervaltrainingonadiponectinleptinratioandcreactiveproteininstreptozotocinnicotinamideinduceddiabeticrats |