The effects of apoptosis inhibitor of macrophage in kidney diseases
Abstract Kidney disease is a progressive and irreversible condition in which immunity is a contributing factor that endangers human health. It is widely acknowledged that macrophages play a significant role in developing and causing numerous kidney diseases. The increasing focus on the mechanism by...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-023-01597-3 |
| _version_ | 1797363480483856384 |
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| author | Yixia Cao Boyan Hu Yunhe Fan Wei Wang Mingxuan Chi Moussa Ide Nasser Kuai Ma Chi Liu |
| author_facet | Yixia Cao Boyan Hu Yunhe Fan Wei Wang Mingxuan Chi Moussa Ide Nasser Kuai Ma Chi Liu |
| author_sort | Yixia Cao |
| collection | DOAJ |
| description | Abstract Kidney disease is a progressive and irreversible condition in which immunity is a contributing factor that endangers human health. It is widely acknowledged that macrophages play a significant role in developing and causing numerous kidney diseases. The increasing focus on the mechanism by which macrophages express apoptosis inhibitor of macrophages (AIM) in renal diseases has been observed. AIM is an apoptosis inhibitor that stops different things that cause apoptosis from working. This keeps AIM-bound cell types alive. Notably, the maintenance of immune cell viability regulates immunity. As our investigation progressed, we concluded that AIM has two sides when it comes to renal diseases. AIM can modulate renal phagocytosis, expedite the elimination of renal tubular cell fragments, and mitigate tissue injury. AIM can additionally exacerbate the development of renal fibrosis and kidney disease by prolonging inflammation. IgA nephropathy (IgAN) may also worsen faster if more protein is in the urine. This is because IgA and immunoglobulin M are found together and expressed. In the review, we provide a comprehensive overview of prior research and concentrate on the impacts of AIM on diverse subcategories of nephropathies. We discovered that AIM is closely associated with renal diseases by playing a positive or negative role in the onset, progression, or cure of kidney disease. AIM is thus a potentially effective therapeutic target for kidney diseases. |
| first_indexed | 2024-03-08T16:21:58Z |
| format | Article |
| id | doaj.art-0133481ff0eb43a29b4f69484b47a108 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-08T16:21:58Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-0133481ff0eb43a29b4f69484b47a1082024-01-07T12:17:22ZengBMCEuropean Journal of Medical Research2047-783X2024-01-0129111310.1186/s40001-023-01597-3The effects of apoptosis inhibitor of macrophage in kidney diseasesYixia Cao0Boyan Hu1Yunhe Fan2Wei Wang3Mingxuan Chi4Moussa Ide Nasser5Kuai Ma6Chi Liu7School of Medicine, University of Electronic Science and Technology of ChinaSchool of Medicine, University of Electronic Science and Technology of ChinaReproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese MedicineDepartment of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of ChinaDepartment of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of ChinaDepartment of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangdong Cardiovascular Institute, Southern Medical UniversityDepartment of Nephrology, Osaka University Graduate School of MedicineDepartment of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of ChinaAbstract Kidney disease is a progressive and irreversible condition in which immunity is a contributing factor that endangers human health. It is widely acknowledged that macrophages play a significant role in developing and causing numerous kidney diseases. The increasing focus on the mechanism by which macrophages express apoptosis inhibitor of macrophages (AIM) in renal diseases has been observed. AIM is an apoptosis inhibitor that stops different things that cause apoptosis from working. This keeps AIM-bound cell types alive. Notably, the maintenance of immune cell viability regulates immunity. As our investigation progressed, we concluded that AIM has two sides when it comes to renal diseases. AIM can modulate renal phagocytosis, expedite the elimination of renal tubular cell fragments, and mitigate tissue injury. AIM can additionally exacerbate the development of renal fibrosis and kidney disease by prolonging inflammation. IgA nephropathy (IgAN) may also worsen faster if more protein is in the urine. This is because IgA and immunoglobulin M are found together and expressed. In the review, we provide a comprehensive overview of prior research and concentrate on the impacts of AIM on diverse subcategories of nephropathies. We discovered that AIM is closely associated with renal diseases by playing a positive or negative role in the onset, progression, or cure of kidney disease. AIM is thus a potentially effective therapeutic target for kidney diseases.https://doi.org/10.1186/s40001-023-01597-3Apoptosis inhibitor of macrophagesKidney diseasesChronic kidney disease |
| spellingShingle | Yixia Cao Boyan Hu Yunhe Fan Wei Wang Mingxuan Chi Moussa Ide Nasser Kuai Ma Chi Liu The effects of apoptosis inhibitor of macrophage in kidney diseases European Journal of Medical Research Apoptosis inhibitor of macrophages Kidney diseases Chronic kidney disease |
| title | The effects of apoptosis inhibitor of macrophage in kidney diseases |
| title_full | The effects of apoptosis inhibitor of macrophage in kidney diseases |
| title_fullStr | The effects of apoptosis inhibitor of macrophage in kidney diseases |
| title_full_unstemmed | The effects of apoptosis inhibitor of macrophage in kidney diseases |
| title_short | The effects of apoptosis inhibitor of macrophage in kidney diseases |
| title_sort | effects of apoptosis inhibitor of macrophage in kidney diseases |
| topic | Apoptosis inhibitor of macrophages Kidney diseases Chronic kidney disease |
| url | https://doi.org/10.1186/s40001-023-01597-3 |
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