Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection
Abstract Background Schistosoma japonicum infection is an important public health problem, imposing heavy social and economic burdens in 78 countries worldwide. However, the mechanism of transition from chronic to advanced S. japonicum infection remains largely unknown. Evidences suggested that gut...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-022-05539-6 |
| _version_ | 1797988381990322176 |
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| author | Chen Zhou Junhui Li Chen Guo Zhaoqin Zhou Zhen Yang Yu Zhang Jie Jiang Yu Cai Jie Zhou Yingzi Ming |
| author_facet | Chen Zhou Junhui Li Chen Guo Zhaoqin Zhou Zhen Yang Yu Zhang Jie Jiang Yu Cai Jie Zhou Yingzi Ming |
| author_sort | Chen Zhou |
| collection | DOAJ |
| description | Abstract Background Schistosoma japonicum infection is an important public health problem, imposing heavy social and economic burdens in 78 countries worldwide. However, the mechanism of transition from chronic to advanced S. japonicum infection remains largely unknown. Evidences suggested that gut microbiota plays a role in the pathogenesis of S. japonicum infection. However, the composition of the gut microbiota in patients with chronic and advanced S. japonicum infection is not well defined. In this study, we compared the composition of the intestinal flora in patients with chronic and advanced S. japonicum infection. Methods The feces of 24 patients with chronic S. japonicum infection and five patients with advanced S. japonicum infection from the same area were collected according to standard procedures, and 16S rRNA sequencing technology was used to analyze the intestinal microbial composition of the two groups of patients. Results We found that alteration occurs in the gut microbiota between the groups of patients with chronic and advanced S. japonicum infections. Analysis of alpha and beta diversity indicated that the diversity and abundance of intestinal flora in patients with advanced S. japonicum infection were lower than those in patients with chronic S. japonicum infection. Furthermore, Prevotella 9, Subdoligranulum, Ruminococcus torques, Megamonas and Fusicatenibacter seemed to have potential to discriminate different stages of S. japonicum infection and to act as biomarkers for diagnosis. Function prediction analysis revealed that microbiota function in the chronic group was focused on translation and cell growth and death, while that in the advanced group was concentrated on elevating metabolism-related functions. Conclusions Our study demonstrated that alteration in gut microbiota in different stages of S. japonicum infection plays a potential role in the pathogenesis of transition from chronic to advanced S. japonicum infection. However, further validation in the clinic is needed, and the underlying mechanism requires further study. |
| first_indexed | 2024-04-11T08:03:14Z |
| format | Article |
| id | doaj.art-013389eb20b348ec977d257aea677c86 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-04-11T08:03:14Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-013389eb20b348ec977d257aea677c862022-12-22T04:35:38ZengBMCParasites & Vectors1756-33052022-11-0115111510.1186/s13071-022-05539-6Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infectionChen Zhou0Junhui Li1Chen Guo2Zhaoqin Zhou3Zhen Yang4Yu Zhang5Jie Jiang6Yu Cai7Jie Zhou8Yingzi Ming9Transplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversityTransplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversityTransplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversityTransplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversityTransplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversityTransplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversityTransplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversitySchistosomiasis Control Institute of Hunan ProvinceSchistosomiasis Control Institute of Hunan ProvinceTransplantation Center, Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, The Third Xiangya Hospital, Central South UniversityAbstract Background Schistosoma japonicum infection is an important public health problem, imposing heavy social and economic burdens in 78 countries worldwide. However, the mechanism of transition from chronic to advanced S. japonicum infection remains largely unknown. Evidences suggested that gut microbiota plays a role in the pathogenesis of S. japonicum infection. However, the composition of the gut microbiota in patients with chronic and advanced S. japonicum infection is not well defined. In this study, we compared the composition of the intestinal flora in patients with chronic and advanced S. japonicum infection. Methods The feces of 24 patients with chronic S. japonicum infection and five patients with advanced S. japonicum infection from the same area were collected according to standard procedures, and 16S rRNA sequencing technology was used to analyze the intestinal microbial composition of the two groups of patients. Results We found that alteration occurs in the gut microbiota between the groups of patients with chronic and advanced S. japonicum infections. Analysis of alpha and beta diversity indicated that the diversity and abundance of intestinal flora in patients with advanced S. japonicum infection were lower than those in patients with chronic S. japonicum infection. Furthermore, Prevotella 9, Subdoligranulum, Ruminococcus torques, Megamonas and Fusicatenibacter seemed to have potential to discriminate different stages of S. japonicum infection and to act as biomarkers for diagnosis. Function prediction analysis revealed that microbiota function in the chronic group was focused on translation and cell growth and death, while that in the advanced group was concentrated on elevating metabolism-related functions. Conclusions Our study demonstrated that alteration in gut microbiota in different stages of S. japonicum infection plays a potential role in the pathogenesis of transition from chronic to advanced S. japonicum infection. However, further validation in the clinic is needed, and the underlying mechanism requires further study.https://doi.org/10.1186/s13071-022-05539-6Schistosoma. japonicumGut microbiotaBiomarkerChronic S. japonicum infectionAdvanced S. japonicum infection |
| spellingShingle | Chen Zhou Junhui Li Chen Guo Zhaoqin Zhou Zhen Yang Yu Zhang Jie Jiang Yu Cai Jie Zhou Yingzi Ming Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection Parasites & Vectors Schistosoma. japonicum Gut microbiota Biomarker Chronic S. japonicum infection Advanced S. japonicum infection |
| title | Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection |
| title_full | Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection |
| title_fullStr | Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection |
| title_full_unstemmed | Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection |
| title_short | Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection |
| title_sort | comparison of intestinal flora between patients with chronic and advanced schistosoma japonicum infection |
| topic | Schistosoma. japonicum Gut microbiota Biomarker Chronic S. japonicum infection Advanced S. japonicum infection |
| url | https://doi.org/10.1186/s13071-022-05539-6 |
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