The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients
Objectives: This study is a retrospective investigation of the effects of repetitive botulinum toxin A therapy (BoNT-A) and intensive rehabilitation (IR) on lower limb spasticity in post-stroke patients. Methods: Thirty-five post-stroke patients was included in this study and received BoNT-A for the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-08-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/10/9/349 |
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| author | Takatoshi Hara Masahiro Abo Hiroyoshi Hara Nobuyuki Sasaki Naoki Yamada Masachika Niimi Yusuke Shimamoto |
| author_facet | Takatoshi Hara Masahiro Abo Hiroyoshi Hara Nobuyuki Sasaki Naoki Yamada Masachika Niimi Yusuke Shimamoto |
| author_sort | Takatoshi Hara |
| collection | DOAJ |
| description | Objectives: This study is a retrospective investigation of the effects of repetitive botulinum toxin A therapy (BoNT-A) and intensive rehabilitation (IR) on lower limb spasticity in post-stroke patients. Methods: Thirty-five post-stroke patients was included in this study and received BoNT-A for the first time. A 12-day inpatient protocol was with 4 cycles of the treatment protocol. The severity of spasticity, motor function and brace status were evaluated. Results: The modified Ashworth Scale (MAS) score of ankle dorsiflexors, range of motion, walking speed and balancing ability were significantly improved after cycle 1. The improvement of spasticity and motor function was persistent through cycles 2–4. One-third of brace users were able to discontinue the use of a brace. All of these brace users showed a forward gait pattern prior to therapy. Conclusions: Repeated BoNT-A combined with IR improved lower limb spasticity in post-stroke patients. Our results suggest that patients who show the forward gait pattern prior to therapy may be able to discontinue the use of their brace after therapy. |
| first_indexed | 2024-04-11T20:54:15Z |
| format | Article |
| id | doaj.art-013531267247458d98402eaa5ff537d4 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T20:54:15Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-013531267247458d98402eaa5ff537d42022-12-22T04:03:43ZengMDPI AGToxins2072-66512018-08-0110934910.3390/toxins10090349toxins10090349The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke PatientsTakatoshi Hara0Masahiro Abo1Hiroyoshi Hara2Nobuyuki Sasaki3Naoki Yamada4Masachika Niimi5Yusuke Shimamoto6Department of Rehabilitaion Medicine, The Jikei University School of Medicine, 1058461 Tokyo, JapanDepartment of Rehabilitaion Medicine, The Jikei University School of Medicine, 1058461 Tokyo, JapanDepartment of Rehabilitaion Medicine, Kikyogahara Hospital 1295, 3996461 Nagano, JapanDepartment of Rehabilitaion Medicine, The Jikei University School of Medicine, 1058461 Tokyo, JapanDepartment of Rehabilitaion Medicine, The Jikei University School of Medicine, 1058461 Tokyo, JapanDepartment of Rehabilitaion Medicine, The Jikei University School of Medicine, 1058461 Tokyo, JapanDepartment of Rehabilitaion Medicine, Kikyogahara Hospital 1295, 3996461 Nagano, JapanObjectives: This study is a retrospective investigation of the effects of repetitive botulinum toxin A therapy (BoNT-A) and intensive rehabilitation (IR) on lower limb spasticity in post-stroke patients. Methods: Thirty-five post-stroke patients was included in this study and received BoNT-A for the first time. A 12-day inpatient protocol was with 4 cycles of the treatment protocol. The severity of spasticity, motor function and brace status were evaluated. Results: The modified Ashworth Scale (MAS) score of ankle dorsiflexors, range of motion, walking speed and balancing ability were significantly improved after cycle 1. The improvement of spasticity and motor function was persistent through cycles 2–4. One-third of brace users were able to discontinue the use of a brace. All of these brace users showed a forward gait pattern prior to therapy. Conclusions: Repeated BoNT-A combined with IR improved lower limb spasticity in post-stroke patients. Our results suggest that patients who show the forward gait pattern prior to therapy may be able to discontinue the use of their brace after therapy.http://www.mdpi.com/2072-6651/10/9/349botulinum toxin A therapystrokerehabilitation |
| spellingShingle | Takatoshi Hara Masahiro Abo Hiroyoshi Hara Nobuyuki Sasaki Naoki Yamada Masachika Niimi Yusuke Shimamoto The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients Toxins botulinum toxin A therapy stroke rehabilitation |
| title | The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients |
| title_full | The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients |
| title_fullStr | The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients |
| title_full_unstemmed | The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients |
| title_short | The Effect of Repeated Botulinum Toxin A Therapy Combined with Intensive Rehabilitation on Lower Limb Spasticity in Post-Stroke Patients |
| title_sort | effect of repeated botulinum toxin a therapy combined with intensive rehabilitation on lower limb spasticity in post stroke patients |
| topic | botulinum toxin A therapy stroke rehabilitation |
| url | http://www.mdpi.com/2072-6651/10/9/349 |
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