Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases
Hai Liu,1,2 Jianqiong Yang,3 Wanqing Yang,1 Shaonan Hu,1 Yali Wu,1 Bo Zhao,1 Haiyan Hu,1 Shouying Du1 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi, People&am...
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| Format: | Article |
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Dove Medical Press
2020-02-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/focus-on-notoginsenoside-r1-in-metabolism-and-prevention-against-human-peer-reviewed-article-DDDT |
| _version_ | 1811263263815499776 |
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| author | Liu H Yang J Yang W Hu S Wu Y Zhao B Hu H Du S |
| author_facet | Liu H Yang J Yang W Hu S Wu Y Zhao B Hu H Du S |
| author_sort | Liu H |
| collection | DOAJ |
| description | Hai Liu,1,2 Jianqiong Yang,3 Wanqing Yang,1 Shaonan Hu,1 Yali Wu,1 Bo Zhao,1 Haiyan Hu,1 Shouying Du1 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 3Department of Clinical Research Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of ChinaCorrespondence: Shouying DuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 North 3rd Ring East Road, Chaoyang District, Beijing, People’s Republic of ChinaTel +86 17812165051Fax +86 10 64286231Email dumenzidi123@163.comAbstract: Notoginsenoside (NG)-R1 is one of the main bioactive compounds from Panax notoginseng (PN) root, which is well known in the prescription for mediating the micro-circulatory hemostasis in human. In this article, we mainly discuss NG-R1 in metabolism and the biological activities, including cardiovascular protection, neuro-protection, anti-diabetes, liver protection, gastrointestinal protection, lung protection, bone metabolism regulation, renal protection, and anti-cancer. The metabolites produced by deglycosylation of NG-R1 exhibit higher permeability and bioavailability. It has been extensively verified that NG-R1 may ameliorate ischemia-reperfusion (IR)-induced injury in cardiovascular and neuronal systems mainly by upregulating the activity of estrogen receptor α-dependent phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and nuclear factor erythroid-2-related factor 2 (NRF2) pathways and downregulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. However, no specific targets for NG-R1 have been identified. Expectedly, NG-R1 has been used as a main bioactive compound in many Traditional Chinese Medicines clinically, such as Xuesaitong, Naodesheng, XueShuanTong, ShenMai, and QSYQ. These suggest that NG-R1 exhibits a significant potency in drug development.Keywords: notoginsenoside (NG)-R1, Panax notoginseng, micro-circulatory hemostasis, permeability, bioavailability |
| first_indexed | 2024-04-12T19:41:33Z |
| format | Article |
| id | doaj.art-01354a92fc694519aad6275908dcdf3d |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-04-12T19:41:33Z |
| publishDate | 2020-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-01354a92fc694519aad6275908dcdf3d2022-12-22T03:19:03ZengDove Medical PressDrug Design, Development and Therapy1177-88812020-02-01Volume 1455156551645Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human DiseasesLiu HYang JYang WHu SWu YZhao BHu HDu SHai Liu,1,2 Jianqiong Yang,3 Wanqing Yang,1 Shaonan Hu,1 Yali Wu,1 Bo Zhao,1 Haiyan Hu,1 Shouying Du1 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 3Department of Clinical Research Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of ChinaCorrespondence: Shouying DuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 North 3rd Ring East Road, Chaoyang District, Beijing, People’s Republic of ChinaTel +86 17812165051Fax +86 10 64286231Email dumenzidi123@163.comAbstract: Notoginsenoside (NG)-R1 is one of the main bioactive compounds from Panax notoginseng (PN) root, which is well known in the prescription for mediating the micro-circulatory hemostasis in human. In this article, we mainly discuss NG-R1 in metabolism and the biological activities, including cardiovascular protection, neuro-protection, anti-diabetes, liver protection, gastrointestinal protection, lung protection, bone metabolism regulation, renal protection, and anti-cancer. The metabolites produced by deglycosylation of NG-R1 exhibit higher permeability and bioavailability. It has been extensively verified that NG-R1 may ameliorate ischemia-reperfusion (IR)-induced injury in cardiovascular and neuronal systems mainly by upregulating the activity of estrogen receptor α-dependent phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and nuclear factor erythroid-2-related factor 2 (NRF2) pathways and downregulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. However, no specific targets for NG-R1 have been identified. Expectedly, NG-R1 has been used as a main bioactive compound in many Traditional Chinese Medicines clinically, such as Xuesaitong, Naodesheng, XueShuanTong, ShenMai, and QSYQ. These suggest that NG-R1 exhibits a significant potency in drug development.Keywords: notoginsenoside (NG)-R1, Panax notoginseng, micro-circulatory hemostasis, permeability, bioavailabilityhttps://www.dovepress.com/focus-on-notoginsenoside-r1-in-metabolism-and-prevention-against-human-peer-reviewed-article-DDDTnotoginsenoside (ng)-r1panax notoginsengmicro-circulatory hemostasispermeabilitybioavailability |
| spellingShingle | Liu H Yang J Yang W Hu S Wu Y Zhao B Hu H Du S Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases Drug Design, Development and Therapy notoginsenoside (ng)-r1 panax notoginseng micro-circulatory hemostasis permeability bioavailability |
| title | Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases |
| title_full | Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases |
| title_fullStr | Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases |
| title_full_unstemmed | Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases |
| title_short | Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases |
| title_sort | focus on notoginsenoside r1 in metabolism and prevention against human diseases |
| topic | notoginsenoside (ng)-r1 panax notoginseng micro-circulatory hemostasis permeability bioavailability |
| url | https://www.dovepress.com/focus-on-notoginsenoside-r1-in-metabolism-and-prevention-against-human-peer-reviewed-article-DDDT |
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