A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats
Considering the global health threat posed by kidney disease burden, a search for new nephroprotective drugs from our local flora could prove a powerful strategy to respond to this health threat. In this study we investigated the antihyperuricemic and nephroprotective potential of RA-3, a plant-deri...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/17/4010 |
| _version_ | 1797554746668613632 |
|---|---|
| author | Nomadlozi Blessings Hlophe Andrew Rowland Opoku Foluso Oluwagbemiga Osunsanmi Trayana Georgieva Djarova-Daniels Oladipupo Adejumobi Lawal Rebamang Anthony Mosa |
| author_facet | Nomadlozi Blessings Hlophe Andrew Rowland Opoku Foluso Oluwagbemiga Osunsanmi Trayana Georgieva Djarova-Daniels Oladipupo Adejumobi Lawal Rebamang Anthony Mosa |
| author_sort | Nomadlozi Blessings Hlophe |
| collection | DOAJ |
| description | Considering the global health threat posed by kidney disease burden, a search for new nephroprotective drugs from our local flora could prove a powerful strategy to respond to this health threat. In this study we investigated the antihyperuricemic and nephroprotective potential of RA-3, a plant-derived lanosteryl triterpene. The antihyperuricemic and nephroprotective effect of RA-3 was investigated using the adenine and gentamicin induced hyperuricemic and nephrotoxicity rat model. Following the induction of hyperuricemia and nephrotoxicity, the experimental model rats (Sprague Dawley) were orally administered with RA-3 at 50 and 100 mg/kg body weight, respectively, daily for 14 days. Treatment of the experimental rats with RA-3, especially at 100 mg/kg, effectively lowered the serum renal dysfunction (blood urea nitrogen and creatinine) and hyperuricemic (uric acid and xanthine oxidase) biomarkers. These were accompanied by increased antioxidant status with decrease in malondialdehyde content. A much improved histomorphological structure of the kidney tissues was also observed in the triterpene treated groups when compared to the model control group. It is evident that RA-3 possesses the antihyperuricemic and nephroprotective properties, which could be vital for prevention and amelioration of kidney disease. |
| first_indexed | 2024-03-10T16:37:25Z |
| format | Article |
| id | doaj.art-01357b02f92b430ba1120699b11b29f2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T16:37:25Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-01357b02f92b430ba1120699b11b29f22023-11-20T12:18:46ZengMDPI AGMolecules1420-30492020-09-012517401010.3390/molecules25174010A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in RatsNomadlozi Blessings Hlophe0Andrew Rowland Opoku1Foluso Oluwagbemiga Osunsanmi2Trayana Georgieva Djarova-Daniels3Oladipupo Adejumobi Lawal4Rebamang Anthony Mosa5Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Agriculture, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaProducts Research Unit, Department of Chemistry, Lagos State University, 102101 Lagos, NigeriaDepartment of Biochemistry, Genetics and Microbiology, Division of Biochemistry, University of Pretoria, Hatfield 0028, South AfricaConsidering the global health threat posed by kidney disease burden, a search for new nephroprotective drugs from our local flora could prove a powerful strategy to respond to this health threat. In this study we investigated the antihyperuricemic and nephroprotective potential of RA-3, a plant-derived lanosteryl triterpene. The antihyperuricemic and nephroprotective effect of RA-3 was investigated using the adenine and gentamicin induced hyperuricemic and nephrotoxicity rat model. Following the induction of hyperuricemia and nephrotoxicity, the experimental model rats (Sprague Dawley) were orally administered with RA-3 at 50 and 100 mg/kg body weight, respectively, daily for 14 days. Treatment of the experimental rats with RA-3, especially at 100 mg/kg, effectively lowered the serum renal dysfunction (blood urea nitrogen and creatinine) and hyperuricemic (uric acid and xanthine oxidase) biomarkers. These were accompanied by increased antioxidant status with decrease in malondialdehyde content. A much improved histomorphological structure of the kidney tissues was also observed in the triterpene treated groups when compared to the model control group. It is evident that RA-3 possesses the antihyperuricemic and nephroprotective properties, which could be vital for prevention and amelioration of kidney disease.https://www.mdpi.com/1420-3049/25/17/4010RA-3nephrotoxicitytriterpeneantioxidanthyperuricemia |
| spellingShingle | Nomadlozi Blessings Hlophe Andrew Rowland Opoku Foluso Oluwagbemiga Osunsanmi Trayana Georgieva Djarova-Daniels Oladipupo Adejumobi Lawal Rebamang Anthony Mosa A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats Molecules RA-3 nephrotoxicity triterpene antioxidant hyperuricemia |
| title | A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats |
| title_full | A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats |
| title_fullStr | A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats |
| title_full_unstemmed | A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats |
| title_short | A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats |
| title_sort | lanosteryl triterpene ra 3 exhibits antihyperuricemic and nephroprotective effects in rats |
| topic | RA-3 nephrotoxicity triterpene antioxidant hyperuricemia |
| url | https://www.mdpi.com/1420-3049/25/17/4010 |
| work_keys_str_mv | AT nomadloziblessingshlophe alanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT andrewrowlandopoku alanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT folusooluwagbemigaosunsanmi alanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT trayanageorgievadjarovadaniels alanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT oladipupoadejumobilawal alanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT rebamanganthonymosa alanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT nomadloziblessingshlophe lanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT andrewrowlandopoku lanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT folusooluwagbemigaosunsanmi lanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT trayanageorgievadjarovadaniels lanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT oladipupoadejumobilawal lanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats AT rebamanganthonymosa lanosteryltriterpenera3exhibitsantihyperuricemicandnephroprotectiveeffectsinrats |