The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial
Abstract Introduction Vitamin D deficiency has been reported to affect liver function biomarkers. This study was aimed to investigate the effect of consuming vitamin D fortified low-fat dairy products on liver function tests in adults with abdominal obesity. Methods This total blinded randomized con...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-023-00401-6 |
| _version_ | 1797558842548027392 |
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| author | Payam Sharifan Susan Darroudi Mahdi Rafiee Kiarash Roustai Geraylow Romina Hemmati Mohammad Rashidmayvan Mohamad Safarian Saeid Eslami Hassan Vatanparast Reza Zare-Feizabadi Maryam Mohammadi-Bjgiran Hamideh Ghazizadeh Zahra Khorasanchi Mohammad Bagherniya Gordon Ferns Mitra Rezaie Majid Ghayour-Mobarhan |
| author_facet | Payam Sharifan Susan Darroudi Mahdi Rafiee Kiarash Roustai Geraylow Romina Hemmati Mohammad Rashidmayvan Mohamad Safarian Saeid Eslami Hassan Vatanparast Reza Zare-Feizabadi Maryam Mohammadi-Bjgiran Hamideh Ghazizadeh Zahra Khorasanchi Mohammad Bagherniya Gordon Ferns Mitra Rezaie Majid Ghayour-Mobarhan |
| author_sort | Payam Sharifan |
| collection | DOAJ |
| description | Abstract Introduction Vitamin D deficiency has been reported to affect liver function biomarkers. This study was aimed to investigate the effect of consuming vitamin D fortified low-fat dairy products on liver function tests in adults with abdominal obesity. Methods This total blinded randomized controlled trial was undertaken on otherwise healthy abdominally obese adults living in Mashhad, Iran. Milk and yogurt were fortified with 1500 IU vitamin D3 nano-capsules. Participants were randomized to receive fortified milk (n = 73), plain milk (n = 73), fortified yogurt (n = 69), and plain yogurt (n = 74) for 10 weeks. Blood samples were taken at baseline and at the end of the study to assess serum levels of vitamin D, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase (ALP), and Gamma glutamyl transferase. Results A total of 289 participants completed the study (54% female). The groups were homogenous in terms of age, sex, weight, energy intake, and physical activity level (p-value > 0.05). After the trial, vitamin D serum levels were significantly increased in both groups receiving fortified products (both p < 0.001). There was a significant time*group effect only in serum ALP (p < 0.001). Conclusion Consumption of dairy products fortified by 1500 IU vitamin D3 might have detrimental effects on serum levels of some liver enzymes in individuals with abdominal obesity. Further studies needed to determine these effects and underlying mechanisms. Trial registration: IRCT20101130005280N27 . |
| first_indexed | 2024-03-10T17:37:05Z |
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| id | doaj.art-0136145b6f724c038b73d961f5efbd34 |
| institution | Directory Open Access Journal |
| issn | 2072-1315 |
| language | English |
| last_indexed | 2024-03-10T17:37:05Z |
| publishDate | 2023-09-01 |
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| series | Journal of Health, Population and Nutrition |
| spelling | doaj.art-0136145b6f724c038b73d961f5efbd342023-11-20T09:48:36ZengBMCJournal of Health, Population and Nutrition2072-13152023-09-0142111110.1186/s41043-023-00401-6The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trialPayam Sharifan0Susan Darroudi1Mahdi Rafiee2Kiarash Roustai Geraylow3Romina Hemmati4Mohammad Rashidmayvan5Mohamad Safarian6Saeid Eslami7Hassan Vatanparast8Reza Zare-Feizabadi9Maryam Mohammadi-Bjgiran10Hamideh Ghazizadeh11Zahra Khorasanchi12Mohammad Bagherniya13Gordon Ferns14Mitra Rezaie15Majid Ghayour-Mobarhan16Department of Nutrition, School of Medicine, Mashhad University of Medical SciencesInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition, School of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition, School of Medicine, Mashhad University of Medical SciencesDepartment of Medical Informatics, School of Medicine, Mashhad University of Medical SciencesCollege of Pharmacy and Nutrition, School of Public Health, University of SaskatchewanInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesDepartment of Nutrition, School of Medicine, Mashhad University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical SciencesDivision of Medical Education, Brighton and Sussex Medical SchoolDepartment of Nutrition, School of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition, School of Medicine, Mashhad University of Medical SciencesAbstract Introduction Vitamin D deficiency has been reported to affect liver function biomarkers. This study was aimed to investigate the effect of consuming vitamin D fortified low-fat dairy products on liver function tests in adults with abdominal obesity. Methods This total blinded randomized controlled trial was undertaken on otherwise healthy abdominally obese adults living in Mashhad, Iran. Milk and yogurt were fortified with 1500 IU vitamin D3 nano-capsules. Participants were randomized to receive fortified milk (n = 73), plain milk (n = 73), fortified yogurt (n = 69), and plain yogurt (n = 74) for 10 weeks. Blood samples were taken at baseline and at the end of the study to assess serum levels of vitamin D, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase (ALP), and Gamma glutamyl transferase. Results A total of 289 participants completed the study (54% female). The groups were homogenous in terms of age, sex, weight, energy intake, and physical activity level (p-value > 0.05). After the trial, vitamin D serum levels were significantly increased in both groups receiving fortified products (both p < 0.001). There was a significant time*group effect only in serum ALP (p < 0.001). Conclusion Consumption of dairy products fortified by 1500 IU vitamin D3 might have detrimental effects on serum levels of some liver enzymes in individuals with abdominal obesity. Further studies needed to determine these effects and underlying mechanisms. Trial registration: IRCT20101130005280N27 .https://doi.org/10.1186/s41043-023-00401-6Vitamin DAbdominal obesityLiver function testRandomized controlled trialRCT |
| spellingShingle | Payam Sharifan Susan Darroudi Mahdi Rafiee Kiarash Roustai Geraylow Romina Hemmati Mohammad Rashidmayvan Mohamad Safarian Saeid Eslami Hassan Vatanparast Reza Zare-Feizabadi Maryam Mohammadi-Bjgiran Hamideh Ghazizadeh Zahra Khorasanchi Mohammad Bagherniya Gordon Ferns Mitra Rezaie Majid Ghayour-Mobarhan The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial Journal of Health, Population and Nutrition Vitamin D Abdominal obesity Liver function test Randomized controlled trial RCT |
| title | The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial |
| title_full | The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial |
| title_fullStr | The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial |
| title_full_unstemmed | The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial |
| title_short | The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial |
| title_sort | effects of low fat dairy products fortified with 1500 iu vitamin d3 on serum liver function biomarkers in adults with abdominal obesity a randomized controlled trial |
| topic | Vitamin D Abdominal obesity Liver function test Randomized controlled trial RCT |
| url | https://doi.org/10.1186/s41043-023-00401-6 |
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