Single‐Cell RNA‐seq Reveals a Developmental Hierarchy Super‐Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer

Single‐Cell RNA‐seq Reveals a Developmental Hierarchy Super‐Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer

Abstract Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non‐genetic intra‐tumoral heterogeneity, the cellular differentiation state and the interplay between subclonal evol...

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Bibliographic Details
Main Authors: Guangzhe Ge, Yang Han, Jianye Zhang, Xinxin Li, Xiaodan Liu, Yanqing Gong, Zhentao Lei, Jie Wang, Weijie Zhu, Yangyang Xu, Yiji Peng, Jianhua Deng, Bao Zhang, Xuesong Li, Liqun Zhou, Huiying He, Weimin Ci
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Advanced Science
Subjects:
cellular ecosystem
epithelial‐to‐mesenchymal transition
prostate cancer
subtype
transcriptional heterogeneity
tumor subclone
Online Access:https://doi.org/10.1002/advs.202105530

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