Quantification of total apolipoprotein E and its specific isoforms in cerebrospinal fluid and blood in Alzheimer’s disease and other neurodegenerative diseases

Quantification of total apolipoprotein E and its specific isoforms in cerebrospinal fluid and blood in Alzheimer’s disease and other neurodegenerative diseases

A targeted mass spectrometric assay was developed for identification and quantification of apoE isoforms (apoE2, E3 and E4), and it was utilized for screening of samples from AD patients (n = 39) and patients with other neurodegenerative disorders (n = 38). The assay showed good linearity with LOQ c...

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Bibliographic Details
Main Authors: Melinda Rezeli, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, Thomas Laurell, Oskar Hansson, György Marko-Varga
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:EuPA Open Proteomics
Subjects:
CSF biomarkers
Alzheimer’s disease
SRM
Protein isoforms
apoE
Online Access:http://www.sciencedirect.com/science/article/pii/S2212968515300143

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