68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality
Abstract Background In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans. Methods Scans of twenty patients were analyzed in this study. Patients were injected with 68G...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | EJNMMI Physics |
| Online Access: | http://link.springer.com/article/10.1186/s40658-020-00322-x |
| _version_ | 1828880399598616576 |
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| author | Vishnu Murthy Raven L. Smith Dora H. Tao Courtney A. Lawhn-Heath Dave E. Korenchan Peder E. Z. Larson Robert R. Flavell Thomas A. Hope |
| author_facet | Vishnu Murthy Raven L. Smith Dora H. Tao Courtney A. Lawhn-Heath Dave E. Korenchan Peder E. Z. Larson Robert R. Flavell Thomas A. Hope |
| author_sort | Vishnu Murthy |
| collection | DOAJ |
| description | Abstract Background In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans. Methods Scans of twenty patients were analyzed in this study. Patients were injected with 68Ga-PSMA-11 (mean, 5.50 ± 1.49 mCi) and imaged on a 3.0 T time-of-flight PET/MRI. PET images were retrospectively reconstructed using 0.5, 1, 2, 4, 7, and 10 min of PET data. Lesion detectability was evaluated on a 5-point Likert Scale for each lesion in each reconstruction. Quantitative analysis was performed measuring image noise and lesion uptake. Results A total of 55 lesions were identified, and lesion detectability increased from 2.07 ± 1.14 for 0.5 min to 4.93 ± 0.26 for 10 min (p < 0.001), with no significant difference detected between 7 and 10 min of scan time. Average SUVmax decreased from 9.89 ± 6.62 for 0.5 min to 8.64 ± 6.81 for 10 min. Noise decreased from 0.72 ± 0.22 for 0.5 min to 0.31 ± 0.12 for 10 min (p < 0.001) and were nearly equivalent between 7 and 10 min. Pairwise interaction terms between size, SUVmax, and scan time were all found to be significant, although the interaction term between SUVmax and scan time was found to be the most significant. Conclusions Increased acquisition duration improves image quality by increasing detectability and reducing noise. In patients with biochemical recurrence, increased acquisition time up to 7 min improves lesion detection. |
| first_indexed | 2024-12-13T09:48:05Z |
| format | Article |
| id | doaj.art-013ad5673fed4615a49ec8ff28489e7a |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-12-13T09:48:05Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-013ad5673fed4615a49ec8ff28489e7a2022-12-21T23:52:00ZengSpringerOpenEJNMMI Physics2197-73642020-08-01711810.1186/s40658-020-00322-x68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image qualityVishnu Murthy0Raven L. Smith1Dora H. Tao2Courtney A. Lawhn-Heath3Dave E. Korenchan4Peder E. Z. Larson5Robert R. Flavell6Thomas A. Hope7Department of Radiology and Biomedical Imaging, University of California San FranciscoDepartment of Radiology and Biomedical Imaging, University of California San FranciscoDepartment of Radiology and Biomedical Imaging, University of California San FranciscoDepartment of Radiology and Biomedical Imaging, University of California San FranciscoDepartment of Radiology and Biomedical Imaging, University of California San FranciscoDepartment of Radiology and Biomedical Imaging, University of California San FranciscoDepartment of Radiology and Biomedical Imaging, University of California San FranciscoDepartment of Radiology and Biomedical Imaging, University of California San FranciscoAbstract Background In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans. Methods Scans of twenty patients were analyzed in this study. Patients were injected with 68Ga-PSMA-11 (mean, 5.50 ± 1.49 mCi) and imaged on a 3.0 T time-of-flight PET/MRI. PET images were retrospectively reconstructed using 0.5, 1, 2, 4, 7, and 10 min of PET data. Lesion detectability was evaluated on a 5-point Likert Scale for each lesion in each reconstruction. Quantitative analysis was performed measuring image noise and lesion uptake. Results A total of 55 lesions were identified, and lesion detectability increased from 2.07 ± 1.14 for 0.5 min to 4.93 ± 0.26 for 10 min (p < 0.001), with no significant difference detected between 7 and 10 min of scan time. Average SUVmax decreased from 9.89 ± 6.62 for 0.5 min to 8.64 ± 6.81 for 10 min. Noise decreased from 0.72 ± 0.22 for 0.5 min to 0.31 ± 0.12 for 10 min (p < 0.001) and were nearly equivalent between 7 and 10 min. Pairwise interaction terms between size, SUVmax, and scan time were all found to be significant, although the interaction term between SUVmax and scan time was found to be the most significant. Conclusions Increased acquisition duration improves image quality by increasing detectability and reducing noise. In patients with biochemical recurrence, increased acquisition time up to 7 min improves lesion detection.http://link.springer.com/article/10.1186/s40658-020-00322-x |
| spellingShingle | Vishnu Murthy Raven L. Smith Dora H. Tao Courtney A. Lawhn-Heath Dave E. Korenchan Peder E. Z. Larson Robert R. Flavell Thomas A. Hope 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality EJNMMI Physics |
| title | 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality |
| title_full | 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality |
| title_fullStr | 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality |
| title_full_unstemmed | 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality |
| title_short | 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality |
| title_sort | 68ga psma 11 pet mri determining ideal acquisition times to reduce noise and increase image quality |
| url | http://link.springer.com/article/10.1186/s40658-020-00322-x |
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