Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/16/3731 |
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| author | Aleksandra Zielińska Filipa Carreiró Ana M. Oliveira Andreia Neves Bárbara Pires D. Nagasamy Venkatesh Alessandra Durazzo Massimo Lucarini Piotr Eder Amélia M. Silva Antonello Santini Eliana B. Souto |
| author_facet | Aleksandra Zielińska Filipa Carreiró Ana M. Oliveira Andreia Neves Bárbara Pires D. Nagasamy Venkatesh Alessandra Durazzo Massimo Lucarini Piotr Eder Amélia M. Silva Antonello Santini Eliana B. Souto |
| author_sort | Aleksandra Zielińska |
| collection | DOAJ |
| description | Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment. |
| first_indexed | 2024-03-10T17:23:00Z |
| format | Article |
| id | doaj.art-013ccd61ee784cfaa1b4227d36e88624 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T17:23:00Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-013ccd61ee784cfaa1b4227d36e886242023-11-20T10:15:27ZengMDPI AGMolecules1420-30492020-08-012516373110.3390/molecules25163731Polymeric Nanoparticles: Production, Characterization, Toxicology and EcotoxicologyAleksandra Zielińska0Filipa Carreiró1Ana M. Oliveira2Andreia Neves3Bárbara Pires4D. Nagasamy Venkatesh5Alessandra Durazzo6Massimo Lucarini7Piotr Eder8Amélia M. Silva9Antonello Santini10Eliana B. Souto11Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalJSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty 643 001, Tamil Nadu, IndiaCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, ItalyCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, ItalyDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60–355 Poznań, PolandDepartment of Biology and Environment, University of Tras-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5001-801 Vila Real, PortugalDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalPolymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.https://www.mdpi.com/1420-3049/25/16/3731polymeric nanoparticlesnanocapsulesnanospherestherapeutic potentialtargeted drug deliverytoxicology |
| spellingShingle | Aleksandra Zielińska Filipa Carreiró Ana M. Oliveira Andreia Neves Bárbara Pires D. Nagasamy Venkatesh Alessandra Durazzo Massimo Lucarini Piotr Eder Amélia M. Silva Antonello Santini Eliana B. Souto Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology Molecules polymeric nanoparticles nanocapsules nanospheres therapeutic potential targeted drug delivery toxicology |
| title | Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology |
| title_full | Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology |
| title_fullStr | Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology |
| title_full_unstemmed | Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology |
| title_short | Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology |
| title_sort | polymeric nanoparticles production characterization toxicology and ecotoxicology |
| topic | polymeric nanoparticles nanocapsules nanospheres therapeutic potential targeted drug delivery toxicology |
| url | https://www.mdpi.com/1420-3049/25/16/3731 |
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